Ravichandran, Kodi S.

Kodi S. Ravichandran

Kodi S. Ravichandran

Primary Appointment

Professor and Chair, Microbiology, Immunology, and Cancer Biology

Education

  • BVSc, Veterinary Medicine, Madras Veterinary College, Madras, India
  • PhD, Molecular and Cell Biology, University of Massachusetts, Amherst, MA
  • Postdoc, Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Contact Information

Jordan Hall, 7th floor, Room 7316
Charlottesville, VA 22908
Telephone: 434-243-6093
Fax: 434-982-1071
Email: ravi@virginia.edu
Website: http://www.healthsystem.virginia.edu/internet/researchfaculty/detail.cfm?people_id=kr4h&hideintro=1

Research Interests

Apoptotic cell clearance mechanisms in health and disease

Research Description

My laboratory has been addressing two main topics over the years: (i) The signals that regulate B and T cell development and function. In this regard, we use a combination of knockout and transgenic mice to address the developmental checkpoint that are in place to regulate T cell development and how they affect immune system function (ref #9,10 below). (ii) The molecules/mechanisms that regulate the process of apoptotic cell clearance. In this context, we address the different steps of the apoptotic cell engulfment process: how apoptotic cells advertise their presence to phagocytes (?find-me signal? release) (ref #7,8,16), how phagocytes recognize and ingest the apoptotic cells (eat-me signals and phagocytic receptors) (ref #1 to 6, and 14), and how the phagocytes digest the ingested corpses (ref #12,13,14). We are also interested in how the engulfment of apoptotic cells is immunologically silent (in contrast to other types of phagocytosis) and how this intersects and integrates with innate immune mechanisms (ref #15 and 16). We use knockout and transgenic mouse models, mammalian cell culture, drug screens, human samples, as well as genetic studies C. elegans.

Selected Publications