Lawrence, Michael B.

Michael B. Lawrence

Michael B. Lawrence

Primary Appointment

Associate Professor, Biomedical Engineering

Education

  • BA, Chemistry, Rice University
  • PhD, Chemical Engineering, Rice University
  • Postdoc, Immunology, Harvard University

Contact Information

MR5, 2111
Charlottesville, VA 22908
Telephone: 434-982-4269
Email: mbl2a@virginia.edu

Research Interests

Vascular and Molecular Engineering

Research Description

Our laboratory is developing applications of molecular mechanics to the challenges of targeted drug and gene delivery. To increase specificity and reduce toxic side effects, we are incorporating leukocyte adhesion receptors into liposomes and polymeric microparticles containing encapsulated therapeutics to target defective cells with high specificity. To this end, we are using a mutagenesis approach coupled with biophysical analysis of mechanically stressed bonds to identify the controlling features of adhesion receptors that permit binding in the presence of fluid shear forces.Additionally, we have developed several model flow systems to examine the dynamics of platelet-leukocyte-vessel wall interactions that take place during the acute phases of an inflammatory challenge or the formation of blood clots on the vessel wall. Common to interactions between platelets, leukocytes, and the vessel wall is the involvement of a family of receptors called selectins that support transient adhesions in which leukocytes and platelets roll along the vessel wall in shear flow. These studies have significance for the understanding of the regulatory effects of blood flow, adhesion receptor expression, and chemokines on inflammatory responses and blood clotting.