Mark D. Okusa
Primary AppointmentJohn C. Buchanan Distinguished Professor of Medicine, Medicine: Nephrology
- Residency, Medical College of Virginia, VCU, Richmond, VA
- MD, Medical College of Virginia
- Fellowship, Yale School of Medicine
Mechanisms of renal injury
(1) Kidney ischemia-reperfusion injury: In vivo studies are aimed at determining the contribution of immune cells to ischemia-reperfusion injury and therapeutic strategies to reduce injury following acute kidney injury with the ultimate goal of bringing novel compounds to clinical trials. Current studies target adenosine 2A receptors and sphingosine 1 phosphate receptors as potential therapeutic approaches to block inflammation and tissue injury. These studies have led to a better understanding of the mechanisms of T cell activation by ischemia-reperfusion and tolerance induction by adenosine 2A compounds.
(2) Diabetic nephropathy: Our approach is to understand the immune mechanisms of injury in diabetic nephropathy and use novel compounds to reduce functional and morphological consequences of diabetic nephropathy.