Mark J. Jameson
Primary AppointmentAssistant Professor, Otolaryngology
- BA, Biology and Chemistry, Point Loma Nazarene College, San Diego, CA
- Postdoc, Cell and Molecular Pharmacology and Experimental Therapeutics, Medical U of South Carolina, Charleston, SC
- MD, Medicine, Medical U of South Carolina, Charleston, SC
- PhD, Cell and Molecular Pharmacology and Experimental Therapeutics, Medical U of South Carolina, Charleston, SC
- Internship, General Surgery, U of Virginia Health System, Charlottesville, VA
- Residency, Otolaryngology Head and Neck Surgery, U of Virginia Health System, Charlottesville, VA
- board certification, Otolaryngology Head and Neck Surgery, American Board of Otolaryngology
- Fellowship, Head and Neck Oncologic and Reconstructive Surgery, U of Iowa Hospitals & Clinics, Iowa City, IA
Involvement of growth factors and resistance to chemotherapy/targeted therapy in squamous cell carcinoma of the head and neck.
My laboratory conducts basic science research on the involvement of growth factors in cancer. Although dysregulation of growth factor systems has been implicated in a variety of cancers, our primary focus is squamous cell carcinoma of the head and neck, which affects the mucosal surfaces of the upper aerodigestive tract. Our main goals involve: (1) identifying the mechanism by which the insulin-like growth factor-1 receptor (IGF-1R) and other growth factor receptors can confer resistance to targeted therapy with anti-epidermal growth factor receptor (EGFR) agents; (2) determining the benefit of inhibiting additional growth factor receptors and/or downstream signaling molecules to increase the therapeutic efficacy of targeted anti-EGFR agents; and (3) discovering methods to predict the susceptibility of a given tumor to targeted therapy with anti-EGFR agents or with combinations of multiple targeted agents. To address these issues, we study cell lines, xenograft models, and human tumor samples using a variety of current and emerging methodologies.
The lab welcomes students or residents interested in focused short-term projects related to our overall interests and goals. These projects provide the student or resident an excellent opportunity to experience the process of testing a scientific hypothesis and to develop or refine technical abilities in bench research. In previous years, two medical students involved in the Medical Student Summer Research Program (MSSRP) have worked in the lab and gone on to win awards at the annual Medical Student Research Day.