Primary AppointmentAssociate Professor, Pharmacology
- PhD, University of Vienna
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
- Resolution of acute and propagation of chronic inflammation.
- Mechanisms of endothelial-monocyte interaction in chronic inflammation.
- Intracellular signaling induced by oxidized lipids.
- Pattern recognition in innate immunity (Toll like receptors).
- Antiinflammatory activities of PPARs.
- Regulation of heme oxygenase-1.
- identify mechanisms by which OxPL modulate a specific immune response and delineate pathways that determine the signal differentiation between OxPL (altered self) and pathogen-associated molecular patterns (PAMPs) such as LPS (non-self),
- investigate how acute inflammation is resolved or driven into a chronic state by OxPL, and
- examine how monocyte specificity is brought about in chronic inflammation. The long-term goals of this research are to understand how oxidative modification of lipids during tissue damage leads to an inadequate immune response during infection, causes disruption of the tightly controlled balance of immune tolerance, and ultimately provokes chronic inflammation.