lymphocyte-front-imageThe Antibody Engineering and Technology Core, formerly the Lymphocyte Culture Center, engineers and produces monoclonal antibodies using current technology and methods backed by many years of experience.

The Core provides:

  • Production and selection of hybridomas
  • Production and purification of antibodies produced in mammalian and E. coli cells
  • Antibody hydridoma sequencing
  • Variable gene cloning (VH/VL)
  • Construction of antibody fragment antibody (scFv, Fab)
  • Antibody chimerization
  • Antibody humanization and affinity maturation
  • Modification of multivalent antibodies format ( bispecific, IgG  and fragment format )
  • Custom culture and scalable production
  • Consultation on antibody services  and technology
  • Cryostorage of hybridomas for future use
  • Production simplified by approved animal experimentation protocols
  • Hands off production for investigators
  • Expertise on use of monoclonal antibodies

The Antibody Engineering and Technology Core is a research core in the School of Medicine and is a core facility for the University of Virginia Cancer Center.  Our services are available to all investigators at the University of Virginia as well as research institutions and biomedical companies outside the University community.  Other institutions recognize the expertise of the core and ask for consultation on the operation and establishment of similar facilities.

Letter to Investigators

ACKNOWLEDGEMENT: All investigators are asked to acknowledge the Antibody Engineering Technology Core and Lymphocyte Culture Center in any publications citing hybridomas created or antibodies produced by our facility.  The Antibody Engineering and Technology Core is supported by the University of Virginia School of Medicine.