{"id":351,"date":"2021-02-19T17:59:11","date_gmt":"2021-02-19T17:59:11","guid":{"rendered":"https:\/\/pharm.virginia.edu\/bayliss\/?p=351"},"modified":"2026-05-21T00:22:40","modified_gmt":"2026-05-21T00:22:40","slug":"351","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/","title":{"rendered":"Yingtang Publication in Nature"},"content":{"rendered":"

\"\"<\/p>\n

Yingtang published her work on a PACAP peptidergic brainstem system in mice that is activated immediately at birth to support breathing\u00a0(Nature 589<\/em>: 426-430, 2021<\/a>). The activation of PACAP expression in RTN respiratory chemoreceptor neurons appears to result from initiation of air breathing; when PACAP is eliminated from RTN neurons in mice, they exhibit blunted breathing reflexes and greater numbers of apneas (pauses in breathing). In mouse pups, these effects are exacerbated by environmental challenges (e.g., thermal), like those associated with SIDS (sudden infant death syndrome). \u00a0Thus, PACAP expression in RTN neurons stimulated by air breathing supports a critical, yet vulnerable, neonatal respiratory system; issues with this system may account for earlier genetic associations of PACAP variants with SIDS. This collaborative work included contributions from various Bayliss lab colleagues, our long-time UVA collaborators (Patrice Guyenet, Ruth Stornetta, Ed Perez-Reyes), the Greg Funk lab (University of Alberta) and Rachel Ross & Brad Lowell (Harvard University).<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Yingtang published her work on a PACAP peptidergic brainstem system in mice that is activated immediately at birth to support breathing\u00a0(Nature 589: 426-430, 2021). The activation of PACAP expression in RTN respiratory chemoreceptor neurons appears to result from initiation of air breathing; when PACAP is eliminated from RTN neurons in mice, they exhibit blunted breathing […]<\/p>\n","protected":false},"author":1777,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2,1],"tags":[4,5],"class_list":["post-351","post","type-post","status-publish","format-standard","hentry","category-news","category-uncategorized","tag-delete","tag-intranet"],"acf":false,"yoast_head":"\nYingtang Publication in Nature - Bayliss Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Yingtang Publication in Nature - Bayliss Lab\" \/>\n<meta property=\"og:description\" content=\"Yingtang published her work on a PACAP peptidergic brainstem system in mice that is activated immediately at birth to support breathing\u00a0(Nature 589: 426-430, 2021). The activation of PACAP expression in RTN respiratory chemoreceptor neurons appears to result from initiation of air breathing; when PACAP is eliminated from RTN neurons in mice, they exhibit blunted breathing […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/\" \/>\n<meta property=\"og:site_name\" content=\"Bayliss Lab\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-19T17:59:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-21T00:22:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/02\/yingtang-news-pic.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"743\" \/>\n\t<meta property=\"og:image:height\" content=\"331\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"zrb8mf@virginia.edu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"zrb8mf@virginia.edu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/\"},\"author\":{\"name\":\"zrb8mf@virginia.edu\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/#\\\/schema\\\/person\\\/37d06d0d7b2d42470a233568c39f02af\"},\"headline\":\"Yingtang Publication in Nature\",\"datePublished\":\"2021-02-19T17:59:11+00:00\",\"dateModified\":\"2026-05-21T00:22:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/\"},\"wordCount\":158,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/wp-content\\\/uploads\\\/sites\\\/498\\\/2021\\\/02\\\/yingtang-news-pic.jpg\",\"keywords\":[\"Delete\",\"Intranet\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/\",\"name\":\"Yingtang Publication in Nature - Bayliss Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/wp-content\\\/uploads\\\/sites\\\/498\\\/2021\\\/02\\\/yingtang-news-pic.jpg\",\"datePublished\":\"2021-02-19T17:59:11+00:00\",\"dateModified\":\"2026-05-21T00:22:40+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/#\\\/schema\\\/person\\\/37d06d0d7b2d42470a233568c39f02af\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/#primaryimage\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/wp-content\\\/uploads\\\/sites\\\/498\\\/2021\\\/02\\\/yingtang-news-pic.jpg\",\"contentUrl\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/wp-content\\\/uploads\\\/sites\\\/498\\\/2021\\\/02\\\/yingtang-news-pic.jpg\",\"width\":743,\"height\":331},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/2021\\\/02\\\/19\\\/351\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Yingtang Publication in Nature\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/#website\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/\",\"name\":\"Bayliss Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/#\\\/schema\\\/person\\\/37d06d0d7b2d42470a233568c39f02af\",\"name\":\"zrb8mf@virginia.edu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g\",\"caption\":\"zrb8mf@virginia.edu\"},\"url\":\"https:\\\/\\\/med.virginia.edu\\\/bayliss\\\/author\\\/zrb8mfvirginia-edu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Yingtang Publication in Nature - Bayliss Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/","og_locale":"en_US","og_type":"article","og_title":"Yingtang Publication in Nature - Bayliss Lab","og_description":"Yingtang published her work on a PACAP peptidergic brainstem system in mice that is activated immediately at birth to support breathing\u00a0(Nature 589: 426-430, 2021). The activation of PACAP expression in RTN respiratory chemoreceptor neurons appears to result from initiation of air breathing; when PACAP is eliminated from RTN neurons in mice, they exhibit blunted breathing […]","og_url":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/","og_site_name":"Bayliss Lab","article_published_time":"2021-02-19T17:59:11+00:00","article_modified_time":"2026-05-21T00:22:40+00:00","og_image":[{"width":743,"height":331,"url":"https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/02\/yingtang-news-pic.jpg","type":"image\/jpeg"}],"author":"zrb8mf@virginia.edu","twitter_card":"summary_large_image","twitter_misc":{"Written by":"zrb8mf@virginia.edu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/#article","isPartOf":{"@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/"},"author":{"name":"zrb8mf@virginia.edu","@id":"https:\/\/med.virginia.edu\/bayliss\/#\/schema\/person\/37d06d0d7b2d42470a233568c39f02af"},"headline":"Yingtang Publication in Nature","datePublished":"2021-02-19T17:59:11+00:00","dateModified":"2026-05-21T00:22:40+00:00","mainEntityOfPage":{"@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/"},"wordCount":158,"commentCount":0,"image":{"@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/#primaryimage"},"thumbnailUrl":"https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/02\/yingtang-news-pic.jpg","keywords":["Delete","Intranet"],"articleSection":["News"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/","url":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/","name":"Yingtang Publication in Nature - Bayliss Lab","isPartOf":{"@id":"https:\/\/med.virginia.edu\/bayliss\/#website"},"primaryImageOfPage":{"@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/#primaryimage"},"image":{"@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/#primaryimage"},"thumbnailUrl":"https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/02\/yingtang-news-pic.jpg","datePublished":"2021-02-19T17:59:11+00:00","dateModified":"2026-05-21T00:22:40+00:00","author":{"@id":"https:\/\/med.virginia.edu\/bayliss\/#\/schema\/person\/37d06d0d7b2d42470a233568c39f02af"},"breadcrumb":{"@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/#primaryimage","url":"https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/02\/yingtang-news-pic.jpg","contentUrl":"https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/02\/yingtang-news-pic.jpg","width":743,"height":331},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/19\/351\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/bayliss\/"},{"@type":"ListItem","position":2,"name":"Yingtang Publication in Nature"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/bayliss\/#website","url":"https:\/\/med.virginia.edu\/bayliss\/","name":"Bayliss Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/bayliss\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/med.virginia.edu\/bayliss\/#\/schema\/person\/37d06d0d7b2d42470a233568c39f02af","name":"zrb8mf@virginia.edu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g","caption":"zrb8mf@virginia.edu"},"url":"https:\/\/med.virginia.edu\/bayliss\/author\/zrb8mfvirginia-edu\/"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/posts\/351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/users\/1777"}],"replies":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/comments?post=351"}],"version-history":[{"count":1,"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/posts\/351\/revisions"}],"predecessor-version":[{"id":486,"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/posts\/351\/revisions\/486"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/media?parent=351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/categories?post=351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/med.virginia.edu\/bayliss\/wp-json\/wp\/v2\/tags?post=351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}