{"id":398,"date":"2021-02-28T14:42:28","date_gmt":"2021-02-28T14:42:28","guid":{"rendered":"https:\/\/pharm.virginia.edu\/bayliss\/?p=398"},"modified":"2026-05-21T00:22:39","modified_gmt":"2026-05-21T00:22:39","slug":"keyong-publication-in-cell-reports","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/28\/keyong-publication-in-cell-reports\/","title":{"rendered":"Keyong Publication in Cell Reports"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>In a recent paper, Keyong uncovered a large subthreshold membrane potential oscillation in the CO<sub>2<\/sub>\/H<sup>+<\/sup>-sensitive retrotrapezoid nucleus<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-399 alignleft\" src=\"https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/06\/Image-for-Keyong-blurb.jpg\" alt=\"\" width=\"255\" height=\"254\" srcset=\"https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/06\/Image-for-Keyong-blurb.jpg 519w, https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/06\/Image-for-Keyong-blurb-300x300.jpg 300w, https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/06\/Image-for-Keyong-blurb-150x150.jpg 150w, https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/06\/Image-for-Keyong-blurb-200x200.jpg 200w, https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/06\/Image-for-Keyong-blurb-100x100.jpg 100w, https:\/\/med.virginia.edu\/bayliss\/wp-content\/uploads\/sites\/498\/2021\/06\/Image-for-Keyong-blurb-70x70.jpg 70w\" sizes=\"(max-width: 255px) 100vw, 255px\" \/> (RTN) neurons that drive brainstem breathing circuits (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124721000279?via%3Dihub\"><em>Cell Reports 34<\/em>: 108714, 2021<\/a>). As reported for the few other neuron types where similar phenomena have been observed, these oscillations required increased intracellular Ca<sup>2+<\/sup> levels provided by L-type Ca channels. However, Keyong also found that that the oscillations were inhibited by blockers of TRPM4, a calcium-dependent cation channel expressed in RTN neurons. The TRPM4 blockers also interfered with excitatory neuromodulation of RTN neurons. Moreover, our UVA Pharmacology colleague, Stephen Abbott, showed that microinjection of TRPM4 blockers directly into the mouse RTN inhibited respiratory output in vivo. This work therefore identifies a novel electrophysiological role for the versatile TRPM4 channel in mediating subthreshold oscillations and driving spontaneous and stimulated neuronal activity. We believe the large TRPM4-dependent oscillations support the pacemaker-like activity in RTN neurons that is required to maintain regular breathing, especially during sleep.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; In a recent paper, Keyong uncovered a large subthreshold membrane potential oscillation in the CO2\/H+-sensitive retrotrapezoid nucleus (RTN) neurons that drive brainstem breathing circuits (Cell Reports 34: 108714, 2021). As reported for the few other neuron types where similar phenomena have been observed, these oscillations required increased intracellular Ca2+ levels provided by L-type Ca [&hellip;]<\/p>\n","protected":false},"author":1777,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[2,1],"tags":[4,5],"class_list":["post-398","post","type-post","status-publish","format-standard","hentry","category-news","category-uncategorized","tag-delete","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Keyong Publication in Cell Reports - Bayliss Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/bayliss\/2021\/02\/28\/keyong-publication-in-cell-reports\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Keyong Publication in Cell Reports - Bayliss Lab\" \/>\n<meta property=\"og:description\" content=\"&nbsp; In a recent paper, Keyong uncovered a large subthreshold membrane potential oscillation in the CO2\/H+-sensitive retrotrapezoid nucleus (RTN) neurons that drive brainstem breathing circuits (Cell Reports 34: 108714, 2021). 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