{"id":821,"date":"2020-09-22T15:58:49","date_gmt":"2020-09-22T19:58:49","guid":{"rendered":"https:\/\/med.virginia.edu\/big\/?p=821"},"modified":"2026-05-22T16:59:19","modified_gmt":"2026-05-22T20:59:19","slug":"uva-identifies-surprising-contributor-to-multiple-sclerosis","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/big\/2020\/09\/22\/uva-identifies-surprising-contributor-to-multiple-sclerosis\/","title":{"rendered":"UVA Identifies Surprising Contributor to Multiple Sclerosis"},"content":{"rendered":"

\"Gaultier<\/p>\n

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October 2019 – C<\/span>ells that scientists have largely ignored when studying multiple sclerosis are actually key contributors to MS development, new research from the\u00a0University of Virginia School of Medicine<\/a>\u00a0shows. The discovery suggests new avenues for devising treatments and is a vital step toward finding a cure.<\/p>\n

Understanding Multiple Sclerosis<\/strong><\/h2>\n

Scientists had assumed that these cells, known as oligodendrocyte progenitor cells, could only serve a favorable role in MS. These glial cells make up about 5% of the brain and spinal cord, and they play an important and beneficial role by making cells that produce myelin \u2013 insulation for nerve cells.<\/p>\n

In MS, the body\u2019s immune system begins to attack the myelin, leading to a progressively disabling neurological condition that affects more than 2 million people worldwide. (MS is the most common neurological condition among the young, and it is often diagnosed between ages 20 and 50.)<\/p>\n

It has been thought that these progenitors do not efficiently give rise to myelin-producing cells in people with MS. But UVA\u2019s Alban Gaultier and his team made the surprising discovery that the cells are also\u00a0actively participating\u00a0in the immune system\u2019s harmful attacks on myelin.<\/p>\n

\u201cThis cell type is modulating the inflammatory environment,\u201d said Anthony\u00a0Fern\u00e1ndez-Casta\u00f1eda, the Ph.D. student who is the first author of the scientific paper outlining the findings. \u201cI was very surprised that these progenitor cells, thought to be a bystander during the inflammatory process, are active contributors to neuroinflammation.\u201d<\/p>\n

Promoting Brain Repair<\/strong><\/h2>\n

The good news: The new insights into the progenitor cells suggest that doctors could potentially manipulate the environment inside the brain to avoid neurodegeneration and promote brain repair. In the lab, blocking the effects of the cells reduced inflammation and aided in myelin restoration.<\/p>\n

\u201cIn MS,\u00a0we have many ways to modulate the initial immune attacks, but we really have no way to promote brain repair,\u201d explained Gaultier, of UVA\u2019s Department of Neuroscience and its Center for Brain Immunology and Glia, or BIG. \u201cTo come up with a cure, we have to target both aspects of the pathology.\u201d<\/p>\n

That will be no easy feat, considering the multiple roles these progenitor cells play. They can\u2019t just be shut down, so scientists would have to develop a more sophisticated approach.<\/p>\n

\u201cIt\u2019s going to take a lot more work to translate these findings to any form of therapy,\u201d Gaultier said. \u201cWe are shining the light on this cell type that very few people have studied as part of the inflammatory response in the brain. More consideration should be given to the varied roles the progenitor cells play when focusing on finding a cure for MS.\u201d<\/p>\n

Findings Published<\/strong><\/h2>\n

The researchers\u00a0published their findings in the scientific journal Acta Neuropathologica<\/strong><\/a>. The study\u2019s authors were Fern\u00e1ndez-Casta\u00f1eda, Megan\u00a0S.\u00a0Chappell, Dorian\u00a0A\u00a0Rosen, Scott\u00a0M.\u00a0Seki, Rebecca\u00a0M.\u00a0Beiter, David\u00a0M.\u00a0Johanson, Delaney\u00a0Liskey, Emily\u00a0Farber, Suna\u00a0Onengut-Gumuscu, Christopher\u00a0C.\u00a0Overall, Jeffrey\u00a0L.\u00a0Dupree and\u00a0Gaultier.<\/p>\n

The research was supported by the National Institutes of Health\u2019s National Institute of Neurological Disorders and Stroke, grants R01 NS083542 and R21 NS111204; the National Multiple Sclerosis Society, grant PP1978; the UVA Double Hoo Research Grant; and the Owens Family Foundation.<\/em><\/p>\n

To keep up with the latest medical research news from UVA, subscribe to the\u00a0<\/em>Making of Medicine<\/em><\/strong><\/a>.<\/p>\n<\/div>\n

By Josh Barney, jdb9a@virginia.edu<\/a>,<\/span>\u00a0434-906-8864<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Understanding Multiple Sclerosis Scientists had assumed that these cells, […]<\/p>\n","protected":false},"author":1546,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[4],"tags":[6],"class_list":["post-821","post","type-post","status-publish","format-standard","hentry","category-news","tag-intranet"],"acf":false,"yoast_head":"\nUVA Identifies Surprising Contributor to Multiple Sclerosis - Center for Brain Immunology and Glia (BIG)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/big\/2020\/09\/22\/uva-identifies-surprising-contributor-to-multiple-sclerosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UVA Identifies Surprising Contributor to Multiple Sclerosis - Center for Brain Immunology and Glia (BIG)\" \/>\n<meta property=\"og:description\" content=\"October 2019 – Cells that scientists have largely ignored when studying multiple sclerosis are actually key contributors to MS development, new research from the\u00a0University of Virginia School of Medicine\u00a0shows. 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