Research in Cardiovascular Biology at UVA focuses on mechanisms that contribute to major cardiovascular diseases such as atherosclerosis, aneurysms, hypertension, peripheral vascular disease, heart failure, myocardial infarction, and stroke.Over 150 former trainees now hold leadership positions in academia, industry, and other biomedical science-related disciplines. Students perform research in one of the many laboratories housed in our world-renowned Robert M. Berne Cardiovascular Research Center (CVRC). Training is augmented through our NIH-funded Cardiovascular Research Training Program, which prepares students for highly successful biomedical research careers in a broad range of areas, including studies of basic cardiovascular development and function. Our research also focuses on the development of novel drugs, devices, diagnostic methods, imaging modalities, and other therapeutic approaches to better diagnose, prevent, or treat cardiovascular disease.
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
T Lymphocyte Responses To Virus Infection
Systems Genetics Approaches to Understand Cardiometabolic Traits
Epigenetic mechanisms involved in complex human disease
Tumor microenvironment and mechanisms of tumor neovascularization
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
Molecular mechanisms controlling insulin signaling and fat synthesis.
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Nanotechnologies for targeted drug delivery
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.
Vascular and Molecular Engineering
Neuronal Vulnerability: A Study of Cellular Mechanism
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Immune System Regulation of Cardiometabolic Disease
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Obesity and Aging
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Apoptotic cell clearance mechanisms in health and disease
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.
Microcirculation, vascular ion channels, calcium signaling mechanisms, endothelial cells, hypertension
Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
The role of clonal hematopoiesis in cardio-metabolic disease processes
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.
Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus