Cardiovascular Biology

cardiovascular system under microscopeResearch in Cardiovascular Biology at UVA focuses on mechanisms that contribute to major cardiovascular diseases such as atherosclerosis, aneurysms, hypertension, peripheral vascular disease, heart failure, myocardial infarction, and stroke.Over 150 former trainees now hold leadership positions in academia, industry, and other biomedical science-related disciplines.   Students perform research in one of the many laboratories housed in our world-renowned Robert M. Berne Cardiovascular Research Center (CVRC).    Training is augmented through our NIH-funded Cardiovascular Research Training Program, which prepares students for highly successful biomedical research careers in a broad range of areas, including studies of basic cardiovascular development and function.  Our research also focuses on the development of novel drugs, devices, diagnostic methods, imaging modalities, and other therapeutic approaches to better diagnose, prevent, or treat cardiovascular disease.

Faculty
  • Barrett, Paula Q.

    Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.

  • Braciale, Thomas J.

    T Lymphocyte Responses To Virus Infection

  • Civelek, Mete

    Systems Genetics Approaches to Understand Cardiometabolic Traits

  • Connelly, Jessica J.

    Epigenetic mechanisms involved in complex human disease

  • Dudley, Andrew

    Tumor microenvironment and mechanisms of tumor neovascularization

  • Engelhard, Victor H.

    Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • French, Brent A.

    Novel Therapies for Treating and Preventing Ischemic Heart Disease

  • Gelfand, Bradley

    Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.

  • Guyenet, Patrice G.

    Neural control of blood pressure and respiration

  • Harris, Thurl E

    Molecular mechanisms controlling insulin signaling and fat synthesis.

  • Holmes, Jeffrey W.

    Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.

  • Hu, Song

    Photoacoustic imaging, light microscopy, neuroscience, cardiovascular biology, cancer, regenerative medicine

  • Isakson, Brant

    Translating our discoveries in the microcirculation to tangible benefits in patients.

  • Janes, Kevin A.

    Systems-biology approaches to cancer biology and virology.

  • Kalani, Mohammad

    Stem cell biology, regenerative medicine, stroke, Wnt signaling, neurogenesis, vasculogenesis, angiogenesis

  • Kelly, Kimberly

    Advancement in the design of imaging agents; molecular imaging and radiological sciences.

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Laubach, Victor E.

    Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.

  • Lawrence, Michael B.

    Vascular and Molecular Engineering

  • Lee, Kevin S.

    Neuronal Vulnerability: A Study of Cellular Mechanism

  • Leitinger, Norbert

    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

  • Lynch, Kevin R.

    Chemical biology of sphingosine 1-phosphate

  • McNamara, Coleen A.

    Atherosclerosis, Obesity, Diabetes

  • Miller, Clint L.

    Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

  • O’Rourke, Eyleen Jorgelina

    Obesity and Aging

  • Owens, Gary K.

    Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Peirce-Cottler, Shayn M.

    Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies

  • Price, Richard J.

    Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis

  • Ravichandran, Kodi S.

    Apoptotic cell clearance mechanisms in health and disease

  • Rich, Stephen S.

    Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis

  • Saucerman, Jeffrey J.

    Roles of complex signaling networks involved in the regulation of cardiovascular function and disease

  • Schulman, Ira G.

    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

  • Somlyo, Avril V.

    Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.

  • Sonkusare, Swapnil

    Microcirculation, vascular ion channels, calcium signaling mechanisms, endothelial cells, hypertension

  • Tung, Kenneth S.

    Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens

  • Wolf, Matthew J

    Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.

  • Yan, Zhen

    Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity

  • Yates, Paul A.

    Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.

  • Yeager, Mark

    Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus