Metabolism

hi res fat cellResearch in Metabolism at UVA focuses on the study of all chemical reactions in an organism and how dysregultation of these processes contributes to disease.These processes are tightly regulated under normal conditions to maintain homeostasis and ensure appropriate energy intake and fuel utilization.  Dysregulation of one or more fundamental metabolic processes causes alterations in glucose or lipid metabolism and transport, mitochondrial function, and cell signaling cascades that lead to chronic disease states such as obesity, diabetes, inflammation, and atherosclerosis.

The metabolism group at UVA actively investigates how and why these defects occur, with the ultimate goal of improving both preventative therapy and treatment.  The diverse expertise of the metabolism group provides training opportunities that utilize molecular and cellular biology in the context of whole animal physiology, drug discovery, and translational medicine.

Students in the metabolism group are supported by several institutional training grants including: Pharmacological Sciences Training GrantCell & Molecular Biology Training GrantNeuroscience Training Program; and Biotechnology Training Program.

Faculty
  • Bland, Michelle

    Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism

  • Bochkis, Irina

    Epigenetic and genetic mechanisms underlying metabolic disease

  • Civelek, Mete

    Systems Genetics Approaches to Understand Cardiometabolic Traits

  • Deppmann, Christopher

    Elucidating and Understanding the Mechanisms Underlying Nervous System Development

  • Ewald, Sarah

    Innate immunity, chronic disease, host-parasite interactions

  • Farber, Charles R.

    Systems Genetics of Skeletal Development and Maintenance

  • Ferris, Heather

    The Role of Diabetes in Cognitive Decline

  • Goldfarb, Adam N.

    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

  • Guler, Jennifer

    Cell Biology and Parasitology.

  • Halme, Adrian J.

    Regeneration and Systemic Responses to Tissue Damage

  • Harris, Thurl E

    Molecular mechanisms controlling insulin signaling and fat synthesis.

  • Hsu, Ku-Lung

    Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry

  • Hu, Song

    Photoacoustic imaging, light microscopy, neuroscience, cardiovascular biology, cancer, regenerative medicine

  • Isakson, Brant

    Translating our discoveries in the microcirculation to tangible benefits in patients.

  • Jiang, Hao

    Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)

  • Kashatus, David F

    The Role of Mitochondrial Fusion and Fission in Tumorigenesis.

  • Keller, Susanna R.

    Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology

  • Kendall, Melissa M.

    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Kundu, Bijoy

    Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy

  • Laurie, Gordon W.

    Role of Prosecretory Mitogen ‘Lacritin’ in Epithelial Homeostasis, Secretion and Innate Defense

  • Leitinger, Norbert

    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

  • O’Rourke, Eyleen Jorgelina

    Obesity and Aging

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Parichy, David

    Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates

  • Park, Kwon-Sik

    Mechanisms of organ development and homeostasis and tumor development

  • Pompano, Rebecca

    Bioanalytical tools for inflammatory disease

  • Ravichandran, Kodi S.

    Apoptotic cell clearance mechanisms in health and disease

  • Schulman, Ira G.

    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

  • Scott, Michael M.

    Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior

  • Smith, Jeffrey S.

    Transcriptional Silencing and Aging in Yeast

  • Wotton, David

    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

  • Yan, Zhen

    Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity

  • Zimring, James C

    Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease