Research in Metabolism at UVA focuses on the study of all chemical reactions in an organism and how dysregultation of these processes contributes to disease.These processes are tightly regulated under normal conditions to maintain homeostasis and ensure appropriate energy intake and fuel utilization. Dysregulation of one or more fundamental metabolic processes causes alterations in glucose or lipid metabolism and transport, mitochondrial function, and cell signaling cascades that lead to chronic disease states such as obesity, diabetes, inflammation, and atherosclerosis.
The metabolism group at UVA actively investigates how and why these defects occur, with the ultimate goal of improving both preventative therapy and treatment. The diverse expertise of the metabolism group provides training opportunities that utilize molecular and cellular biology in the context of whole animal physiology, drug discovery, and translational medicine.
Students in the metabolism group are supported by several institutional training grants including: Pharmacological Sciences Training Grant; Cell & Molecular Biology Training Grant; Neuroscience Training Program; and Biotechnology Training Program.
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Systems Genetics Approaches to Understand Cardiometabolic Traits
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics
Systems Genetics of Skeletal Development and Maintenance
The Role of Diabetes in Cognitive Decline
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Regeneration and Systemic Responses to Tissue Damage
Molecular mechanisms controlling insulin signaling and fat synthesis.
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Translating our discoveries in the microcirculation to tangible benefits in patients.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Nanotechnologies for targeted drug delivery
Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Obesity and Aging
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates
Mechanisms of organ development and homeostasis and tumor development
Bioanalytical tools for inflammatory disease
Apoptotic cell clearance mechanisms in health and disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior
Transcriptional Silencing and Aging in Yeast
The role of clonal hematopoiesis in cardio-metabolic disease processes
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease