Metabolism
Research in Metabolism at UVA focuses on the study of all chemical reactions in an organism and how dysregultation of these processes contributes to disease.These processes are tightly regulated under normal conditions to maintain homeostasis and ensure appropriate energy intake and fuel utilization. Dysregulation of one or more fundamental metabolic processes causes alterations in glucose or lipid metabolism and transport, mitochondrial function, and cell signaling cascades that lead to chronic disease states such as obesity, diabetes, inflammation, and atherosclerosis.
The metabolism group at UVA actively investigates how and why these defects occur, with the ultimate goal of improving both preventative therapy and treatment. The diverse expertise of the metabolism group provides training opportunities that utilize molecular and cellular biology in the context of whole animal physiology, drug discovery, and translational medicine.
Students in the metabolism group are supported by several institutional training grants including: Pharmacological Sciences Training Grant; Cell & Molecular Biology Training Grant; Neuroscience Training Program; and Biotechnology Training Program.
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Bland, Michelle
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
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Bochkis, Irina
Epigenetic and genetic mechanisms underlying metabolic disease
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Civelek, Mete
Systems Genetics Approaches to Understand Cardiometabolic Traits
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Deppmann, Christopher
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
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Ewald, Sarah
Innate immunity, chronic disease, host-parasite interactions
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Farber, Charles R.
Systems Genetics of Skeletal Development and Maintenance
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Ferris, Heather
The Role of Diabetes in Cognitive Decline
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Goldfarb, Adam N.
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
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Guler, Jennifer
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
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Halme, Adrian J.
Regeneration and Systemic Responses to Tissue Damage
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Harris, Thurl E
Molecular mechanisms controlling insulin signaling and fat synthesis.
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Hsu, Ku-Lung
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
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Hu, Song
Photoacoustic imaging, light microscopy, neuroscience, cardiovascular biology, cancer, regenerative medicine
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Isakson, Brant
Translating our discoveries in the microcirculation to tangible benefits in patients.
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Jiang, Hao
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
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Kashatus, David F
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
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Keller, Susanna R.
Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology
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Kendall, Melissa M.
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
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Kester, Mark
Nanotechnologies for targeted drug delivery
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Kundu, Bijoy
Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy
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Laurie, Gordon W.
Role of Prosecretory Mitogen ‘Lacritin’ in Epithelial Homeostasis, Secretion and Innate Defense
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Leitinger, Norbert
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
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O’Rourke, Eyleen Jorgelina
Obesity and Aging
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Papin, Jason A.
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
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Parichy, David
Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates
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Park, Kwon-Sik
Mechanisms of organ development and homeostasis and tumor development
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Pompano, Rebecca
Bioanalytical tools for inflammatory disease
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Ravichandran, Kodi S.
Apoptotic cell clearance mechanisms in health and disease
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Schulman, Ira G.
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
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Scott, Michael M.
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior
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Smith, Jeffrey S.
Transcriptional Silencing and Aging in Yeast
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Wotton, David
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
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Yan, Zhen
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
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Zimring, James C
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease