Holmes, Jeffrey W.
Professor, Biomedical Engineering
Bioinformatics and Genomics, Biotechnology, Cardiovascular Biology, Computational Biology, Physiology, Translational Science
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
The Cardiac Biomechanics Group focuses on the interactions between mechanics, function, and growth and remodeling in the heart. The mechanical properties of normal and diseased myocardium are important determinants of overall heart function. These mechanical properties change during growth, remodeling or disease, often in part as a response to changes in the mechanical environment. Our group studies this interplay between mechanical environment, tissue response, and heart function, not only to better understand the basis for heart disease but also to identify new opportunities to intervene.
Currently, most of our projects are related to myocardial infarction (MI):
1. a translational effort to help prevent MI by developing new quantitative measures of heart wall motion that improve screening for coronary artery disease;
2. a basic biomechanics project focused on understanding how the structure of a healing infarct gives rise to its mechanical properties and how those mechanical properties influence overall heart function; and
3. longer-term efforts to determine how mechanical factors regulate both cardiac wound healing and remodeling of non-infarcted myocardium in post-MI patients