{"id":5389,"date":"2026-04-03T11:25:04","date_gmt":"2026-04-03T15:25:04","guid":{"rendered":"https:\/\/med.virginia.edu\/bims\/?p=5389"},"modified":"2026-04-03T11:25:04","modified_gmt":"2026-04-03T15:25:04","slug":"isabelle-derre-phd-awarded-3-6-million-nih-grant-to-research-chlamydia","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/bims\/isabelle-derre-phd-awarded-3-6-million-nih-grant-to-research-chlamydia\/","title":{"rendered":"Isabelle Derr\u00e9, PhD, Awarded $3.6 Million NIH Grant to Research Chlamydia"},"content":{"rendered":"
\"Isabelle\n

Isabelle Derr\u00e9, PhD<\/p>\n<\/div>\n

Isabelle Derr\u00e9, PhD, an associate professor in the Department of Microbiology, Immunology, and Cancer Biology, was awarded a new five-year $3.6 million grant from the NIH National Institute of Allergy and Infectious Diseases for a project titled, \u201cHost lipid acquisition and maintenance of the\u00a0Chlamydia<\/em>\u00a0replicative niche.\u201d<\/p>\n

Chlamydia trachomatis<\/em>\u00a0is the leading cause of bacterial sexually transmitted infections. No vaccine is currently available. Infections are often asymptomatic, allowing the bacterium to replicate undetected, while damaging reproductive organs. These complications can pose serious risks to women\u2019s reproductive health, including pelvic inflammatory disease, ectopic pregnancy, and infertility.<\/p>\n

In this new project, Dr. Derr\u00e9 and her team will study the role of a\u00a0Chlamydia<\/em>\u00a0protein that maintains the stability of the\u00a0Chlamydia<\/em>-containing vacuole by facilitating the acquisition of host lipids, creating a membrane barrier that allows the bacterium to persist and evade detection.<\/p>\n

Using a multidisciplinary approach, results from these studies will help to further define the fundamental biological mechanisms by which Chlamydia survives and causes disease, while highlighting pathogen-specific targets for potential therapeutics or vaccines.<\/p>\n

 <\/p>\n

Originally posted in Medicine in Motions News March 9, 2026 by\u00a0jta6n@virginia.edu<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Isabelle Derr\u00e9, PhD Isabelle Derr\u00e9, PhD, an associate professor in the Department of Microbiology, Immunology, and Cancer Biology, was awarded a new five-year $3.6 million grant from the NIH National Institute of Allergy and Infectious Diseases for a project titled, \u201cHost lipid acquisition and maintenance of the\u00a0Chlamydia\u00a0replicative niche.\u201d Chlamydia trachomatis\u00a0is the leading cause of bacterial […]<\/p>\n","protected":false},"author":2214,"featured_media":5390,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[4],"tags":[],"class_list":["post-5389","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlights"],"acf":false,"yoast_head":"\nIsabelle Derr\u00e9, PhD, Awarded $3.6 Million NIH Grant to Research Chlamydia - Biomedical Sciences Graduate Program<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/bims\/isabelle-derre-phd-awarded-3-6-million-nih-grant-to-research-chlamydia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Isabelle Derr\u00e9, PhD, Awarded $3.6 Million NIH Grant to Research Chlamydia - 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