{"id":2780,"date":"2021-08-12T12:12:06","date_gmt":"2021-08-12T17:12:06","guid":{"rendered":"https:\/\/bmg.med.virginia.edu\/?p=2780"},"modified":"2026-05-22T20:29:08","modified_gmt":"2026-05-22T20:29:08","slug":"uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/bmg\/2021\/08\/12\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\/","title":{"rendered":"UVA Discovery Suggests Potential New Treatment for Deadly Blood Cancer"},"content":{"rendered":"<div id=\"attachment_2849\" style=\"width: 460px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-2849\" src=\"https:\/\/med.virginia.edu\/bmg\/wp-content\/uploads\/sites\/454\/2021\/08\/mohi_inline_align-right-450x253.jpg\" alt=\"Golam Mohi, a professor in the School of Medicine\u2019s Department of Biochemistry and Molecular Genetics, served as senior researcher. (UVA Health photo)\" width=\"450\" height=\"253\" class=\"size-featured wp-image-2849\" srcset=\"https:\/\/med.virginia.edu\/bmg\/wp-content\/uploads\/sites\/454\/2021\/08\/mohi_inline_align-right-450x253.jpg 450w, https:\/\/med.virginia.edu\/bmg\/wp-content\/uploads\/sites\/454\/2021\/08\/mohi_inline_align-right-600x338.jpg 600w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><p id=\"caption-attachment-2849\" class=\"wp-caption-text\">Golam Mohi, a professor in the School of Medicine\u2019s Department of Biochemistry and Molecular Genetics, served as senior researcher. (UVA Health photo)<\/p><\/div>\n<p>A drug used to treat certain advanced breast cancers may offer a new treatment option for a deadly blood cancer known as myelofibrosis, new research from UVA Cancer Center suggests.<\/p>\n<p>The drug, palbociclib, may be able to prevent the scarring of bone marrow that existing treatments for myelofibrosis cannot. This scarring disrupts the marrow\u2019s production of blood cells and causes severe anemia that leaves patients weak and fatigued. The scarring also reduces the number of platelets in the blood, making clotting difficult, and often causes an enlarged spleen.<\/p>\n<p>\u201cCurrent therapies only provide symptomatic relief without offering significant improvement of bone marrow fibrosis. So, there is a critical need to develop more effective therapy for myelofibrosis,\u201d said senior researcher Golam Mohi of the University of Virginia School of Medicine\u2019s Department of Biochemistry and Molecular Genetics. \u201cWe have identified CDK6, a regulator of cell cycle, as a new therapeutic target in myelofibrosis. We demonstrate that CDK4\/6 inhibitor palbociclib, in combination with ruxolitinib, markedly inhibits myelofibrosis, suggesting this drug combination could be an effective therapeutic strategy against this devastating blood disorder.\u201d<\/p>\n<p><a href=\"https:\/\/news.virginia.edu\/content\/uva-discovery-suggests-potential-new-treatment-deadly-blood-cancer\" target=\"_blank\" rel=\"noopener\">You can find the full article here<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A drug used to treat certain advanced breast cancers may offer a new treatment option for a deadly blood cancer known as myelofibrosis, new research from UVA Cancer Center suggests. The drug, palbociclib, may be able to prevent the scarring of bone marrow that existing treatments for myelofibrosis cannot. This scarring disrupts the marrow\u2019s production [&hellip;]<\/p>\n","protected":false},"author":1777,"featured_media":2228,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3],"tags":[10],"class_list":["post-2780","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlights","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UVA Discovery Suggests Potential New Treatment for Deadly Blood Cancer - Biochemistry and Molecular Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/bmg\/2021\/08\/12\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UVA Discovery Suggests Potential New Treatment for Deadly Blood Cancer - Biochemistry and Molecular Genetics\" \/>\n<meta property=\"og:description\" content=\"A drug used to treat certain advanced breast cancers may offer a new treatment option for a deadly blood cancer known as myelofibrosis, new research from UVA Cancer Center suggests. The drug, palbociclib, may be able to prevent the scarring of bone marrow that existing treatments for myelofibrosis cannot. This scarring disrupts the marrow\u2019s production [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/bmg\/2021\/08\/12\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\/\" \/>\n<meta property=\"og:site_name\" content=\"Biochemistry and Molecular Genetics\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-12T17:12:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-22T20:29:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.virginia.edu\/bmg\/wp-content\/uploads\/sites\/454\/2019\/03\/Mohi.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"100\" \/>\n\t<meta property=\"og:image:height\" content=\"140\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"zrb8mf@virginia.edu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"zrb8mf@virginia.edu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bmg\\\/2021\\\/08\\\/12\\\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bmg\\\/2021\\\/08\\\/12\\\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\\\/\"},\"author\":{\"name\":\"zrb8mf@virginia.edu\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bmg\\\/#\\\/schema\\\/person\\\/37d06d0d7b2d42470a233568c39f02af\"},\"headline\":\"UVA Discovery Suggests Potential New Treatment for Deadly Blood Cancer\",\"datePublished\":\"2021-08-12T17:12:06+00:00\",\"dateModified\":\"2026-05-22T20:29:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bmg\\\/2021\\\/08\\\/12\\\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\\\/\"},\"wordCount\":227,\"image\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bmg\\\/2021\\\/08\\\/12\\\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/med.virginia.edu\\\/bmg\\\/wp-content\\\/uploads\\\/sites\\\/454\\\/2019\\\/03\\\/Mohi.jpg\",\"keywords\":[\"Intranet\"],\"articleSection\":[\"Highlights\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/bmg\\\/2021\\\/08\\\/12\\\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/bmg\\\/2021\\\/08\\\/12\\\/uva-discovery-suggests-potential-new-treatment-for-deadly-blood-cancer-dr-golam-mohi\\\/\",\"name\":\"UVA Discovery Suggests Potential New Treatment for Deadly Blood Cancer - 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