Endothelial cell development and its application to regenerative medicine

April 28, 2020 by rls9ha@virginia.edu


Karen Hirschi

Endothelial cell development and its application to regenerative medicine

Qiu, J. and K.K. Hirschi. (2019) Endothelial cell development and its application to regenerative medicine. Circulation Research 125:489–501.

PMID: 31518171

Abstract

The formation and remodeling of a functional circulatory system is critical for sustaining prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells require further specification to create the unique features of distinct vessel subtypes needed to support tissue morphogenesis. In this review, we explore signaling pathways and transcriptional regulators that modulate endothelial cell differentiation and specification, as well as applications of these processes to stem cell biology and regenerative medicine. We also summarize recent technical advances, including the growing utilization of single-cell sequencing to study vascular heterogeneity and development.


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