{"id":105766,"date":"2021-05-06T11:12:58","date_gmt":"2021-05-06T15:12:58","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=105766"},"modified":"2026-05-21T12:27:59","modified_gmt":"2026-05-21T16:27:59","slug":"karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/","title":{"rendered":"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium"},"content":{"rendered":"

Dr. Karen Hirschi\u2019s laboratory in Cell Biology (along with collaborators from Yale University and Stanford University) are attracting considerable attention for two papers published in December, 2020 (Inside UVa and CBS channel 19 news<\/a>). Dr. Hirschi\u2019s laboratory is already one of the leading laboratories in the world studying the production of blood cells from a subset of vascular endothelial cells (referred to as the endothelial-to-hematopoietic transition or EHT).<\/p>\n

\"Hirshi This is a normal developmental process but a careful understanding of its mechanism could provide clinical tools for producing blood stem cells outside the human body for patients with a variety of conditions. In a paper published in December in Science, Hirschi and her colleagues showed that the pattern of N-glycosylation of various proteins, such as Adam-10, in endothelial cells regulates EHT. The regulation of N-glycosylation of endothelial glycoproteins is itself regulated by a microRNA, miR-223. In a paper published in December in Cell Reports, Hirschi and colleagues showed that retinoic acid signaling is required for the specification of human blood-forming, or hemogenic, endothelial cells. They developed a protocol for deriving endothelial cells from human stem cells and for specifying them as hemogenic endothelial cells. This work has enormous implications for regenerative medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Karen Hirschi\u2019s laboratory in Cell Biology (along with collaborators from Yale University and Stanford University) are attracting considerable attention for two papers published in December, 2020 (Inside UVa and CBS channel 19 news). Dr. Hirschi\u2019s laboratory is already one of the leading laboratories in the world studying the production of blood cells from a […]<\/p>\n","protected":false},"author":1118,"featured_media":105711,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[4],"tags":[21],"class_list":["post-105766","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-highlights","tag-delete"],"acf":false,"yoast_head":"\nKaren Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"Dr. Karen Hirschi\u2019s laboratory in Cell Biology (along with collaborators from Yale University and Stanford University) are attracting considerable attention for two papers published in December, 2020 (Inside UVa and CBS channel 19 news). Dr. Hirschi\u2019s laboratory is already one of the leading laboratories in the world studying the production of blood cells from a […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-06T15:12:58+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-21T16:27:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.virginia.edu\/cell-biology\/wp-content\/uploads\/sites\/193\/2021\/02\/Cell-Biology-Call-out_456cx290-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"398\" \/>\n\t<meta property=\"og:image:height\" content=\"253\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium\",\"datePublished\":\"2021-05-06T15:12:58+00:00\",\"dateModified\":\"2026-05-21T16:27:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/\"},\"wordCount\":219,\"image\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/wp-content\\\/uploads\\\/sites\\\/193\\\/2021\\\/02\\\/Cell-Biology-Call-out_456cx290-1.jpg\",\"keywords\":[\"Delete\"],\"articleSection\":[\"News and Highlights\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/\",\"name\":\"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium - Department of Cell Biology\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/wp-content\\\/uploads\\\/sites\\\/193\\\/2021\\\/02\\\/Cell-Biology-Call-out_456cx290-1.jpg\",\"datePublished\":\"2021-05-06T15:12:58+00:00\",\"dateModified\":\"2026-05-21T16:27:59+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/#primaryimage\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/wp-content\\\/uploads\\\/sites\\\/193\\\/2021\\\/02\\\/Cell-Biology-Call-out_456cx290-1.jpg\",\"contentUrl\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/wp-content\\\/uploads\\\/sites\\\/193\\\/2021\\\/02\\\/Cell-Biology-Call-out_456cx290-1.jpg\",\"width\":398,\"height\":253,\"caption\":\"Research Students in the UVA Department of Cell Biology\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2021\\\/05\\\/06\\\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#website\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/\",\"name\":\"Department of Cell Biology\",\"description\":\"University of Virginia School of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/author\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium - Department of Cell Biology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/","og_locale":"en_US","og_type":"article","og_title":"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium - Department of Cell Biology","og_description":"Dr. Karen Hirschi\u2019s laboratory in Cell Biology (along with collaborators from Yale University and Stanford University) are attracting considerable attention for two papers published in December, 2020 (Inside UVa and CBS channel 19 news). Dr. Hirschi\u2019s laboratory is already one of the leading laboratories in the world studying the production of blood cells from a […]","og_url":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/","og_site_name":"Department of Cell Biology","article_published_time":"2021-05-06T15:12:58+00:00","article_modified_time":"2026-05-21T16:27:59+00:00","og_image":[{"width":398,"height":253,"url":"https:\/\/med.virginia.edu\/cell-biology\/wp-content\/uploads\/sites\/193\/2021\/02\/Cell-Biology-Call-out_456cx290-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Written by":"","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/#article","isPartOf":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/"},"author":{"name":"","@id":""},"headline":"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium","datePublished":"2021-05-06T15:12:58+00:00","dateModified":"2026-05-21T16:27:59+00:00","mainEntityOfPage":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/"},"wordCount":219,"image":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/#primaryimage"},"thumbnailUrl":"https:\/\/med.virginia.edu\/cell-biology\/wp-content\/uploads\/sites\/193\/2021\/02\/Cell-Biology-Call-out_456cx290-1.jpg","keywords":["Delete"],"articleSection":["News and Highlights"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/","url":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/","name":"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium - Department of Cell Biology","isPartOf":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/#website"},"primaryImageOfPage":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/#primaryimage"},"image":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/#primaryimage"},"thumbnailUrl":"https:\/\/med.virginia.edu\/cell-biology\/wp-content\/uploads\/sites\/193\/2021\/02\/Cell-Biology-Call-out_456cx290-1.jpg","datePublished":"2021-05-06T15:12:58+00:00","dateModified":"2026-05-21T16:27:59+00:00","author":{"@id":""},"breadcrumb":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/#primaryimage","url":"https:\/\/med.virginia.edu\/cell-biology\/wp-content\/uploads\/sites\/193\/2021\/02\/Cell-Biology-Call-out_456cx290-1.jpg","contentUrl":"https:\/\/med.virginia.edu\/cell-biology\/wp-content\/uploads\/sites\/193\/2021\/02\/Cell-Biology-Call-out_456cx290-1.jpg","width":398,"height":253,"caption":"Research Students in the UVA Department of Cell Biology"},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/cell-biology\/2021\/05\/06\/karen-hirschi-lab-getting-media-attention-for-recent-publications-on-the-production-of-blood-stem-cells-from-endothelium\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/cell-biology\/"},{"@type":"ListItem","position":2,"name":"Karen Hirschi lab getting media attention for recent publications on the production of blood stem cells from endothelium"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/cell-biology\/#website","url":"https:\/\/med.virginia.edu\/cell-biology\/","name":"Department of Cell Biology","description":"University of Virginia School of Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/cell-biology\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"","url":"https:\/\/med.virginia.edu\/cell-biology\/author\/"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/105766","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/users\/1118"}],"replies":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/comments?post=105766"}],"version-history":[{"count":2,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/105766\/revisions"}],"predecessor-version":[{"id":105768,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/105766\/revisions\/105768"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/media\/105711"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/media?parent=105766"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/categories?post=105766"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/tags?post=105766"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}