{"id":106398,"date":"2023-06-15T11:29:28","date_gmt":"2023-06-15T15:29:28","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=106398"},"modified":"2026-05-21T12:30:29","modified_gmt":"2026-05-21T16:30:29","slug":"nick-chavkin-receives","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/15\/nick-chavkin-receives\/","title":{"rendered":"Nick Chavkin Receives AHA Career Development Award"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-106399\" src=\"https:\/\/med.virginia.edu\/cell-biology\/wp-content\/uploads\/sites\/193\/2023\/06\/Nick-Chavkin.jpeg\" alt=\"Nick Chavkin\" width=\"480\" height=\"640\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Nick Chavkin, a postdoctoral researcher in the CVRC working in the Hirschi and Walsh Labs, has been awarded an American Heart Association (AHA) Career\u00a0Development Award to study age-related loss of the Y chromosome in heart failure. Mosaic loss of Y chromosome (mLOY) in the hematopoietic system is the most common post-zygotic mutation in humans. This form of aneuploidy, in a subset of hematopoietic stem cells, increases with age and affects ~45% of men by age 70. Epidemiological data have associated this condition with mortality, cancer, dementia, and heart failure. A recent study in the Walsh Lab revealed that mLOY promotes a pro-fibrotic response in tissues. Dr. Chavkin\u2019s work will investigate how mLOY disrupts myocardial tissue remodeling and results in cardiac fibrosis that impairs heart function. These studies will reveal novel mechanisms associated with aging and fibrosis, helping us better understand age as a risk factor for heart failure.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Nick Chavkin, a postdoctoral researcher in the CVRC working in the Hirschi and Walsh Labs, has been awarded an American Heart Association (AHA) Career\u00a0Development Award to study age-related loss of the Y chromosome in heart failure. Mosaic loss of Y chromosome (mLOY) in [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[4],"tags":[21],"class_list":["post-106398","post","type-post","status-publish","format-standard","hentry","category-news-and-highlights","tag-delete"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nick Chavkin Receives AHA Career Development Award - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/15\/nick-chavkin-receives\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nick Chavkin Receives AHA Career Development Award - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Nick Chavkin, a postdoctoral researcher in the CVRC working in the Hirschi and Walsh Labs, has been awarded an American Heart Association (AHA) Career\u00a0Development Award to study age-related loss of the Y chromosome in heart failure. 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