{"id":107370,"date":"2021-01-28T17:24:00","date_gmt":"2021-01-28T22:24:00","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107370"},"modified":"2025-05-15T11:12:05","modified_gmt":"2025-05-15T15:12:05","slug":"tissue-resident-macrophage-development-and-function","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2021\/01\/28\/tissue-resident-macrophage-development-and-function\/","title":{"rendered":"Tissue-Resident Macrophage Development and Function"},"content":{"rendered":"

UVA Author:<\/strong> Karen Hirschi
\nCitation:<\/strong> Wu Y, Hirschi KK. Tissue-Resident Macrophage Development and Function. Front Cell Dev Biol. 2021;8:617879. Published 2021 Jan 8. doi:10.3389\/fcell.2020.617879<\/p>\n

DOI:<\/strong> https:\/\/doi.org\/10.3389\/fcell.2020.617879<\/a>
\nPub-Med Number<\/strong>: 33490082<\/p>\n

\n
\n

Tissue-resident macrophages have been associated with important and diverse biological processes such as native immunity, tissue homeostasis and angiogenesis during development and postnatally. Thus, it is critical to understand the origins and functions of tissue-resident macrophages, as well as mechanisms underlying their regulation. It is now well accepted that murine macrophages are produced during three consecutive waves of hematopoietic development. The first wave of macrophage formation takes place during primitive hematopoiesis, which occurs in the yolk sac, and gives rise to primitive erythroid, megakaryocyte and macrophage progenitors. These “primitive” macrophage progenitors ultimately give rise to microglia in the adult brain. The second wave, which also occurs in the yolk sac, generates multipotent erythro-myeloid progenitors (EMP), which give rise to tissue-resident macrophages. Tissue-resident macrophages derived from EMP reside in diverse niches of different tissues except the brain, and demonstrate tissue-specific functions therein. The third wave of macrophages derives from hematopoietic stem cells (HSC) that are formed in the aorta-gonad-mesonephros (AGM) region of the embryo and migrate to, and colonize, the fetal liver. These HSC-derived macrophages are a long-lived pool that will last throughout adulthood. In this review, we discuss the developmental origins of tissue-resident macrophages, their molecular regulation in specific tissues, and their impact on embryonic development and postnatal homeostasis.<\/p>\n<\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

UVA Author: Karen Hirschi Citation: Wu Y, Hirschi KK. Tissue-Resident Macrophage Development and Function. Front Cell Dev Biol. 2021;8:617879. Published 2021 Jan 8. doi:10.3389\/fcell.2020.617879 DOI: https:\/\/doi.org\/10.3389\/fcell.2020.617879 Pub-Med Number: 33490082 Tissue-resident macrophages have been associated with important and diverse biological processes such as native immunity, tissue homeostasis and angiogenesis during development and postnatally. Thus, it is […]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[],"class_list":["post-107370","post","type-post","status-publish","format-standard","hentry","category-featured-publications"],"acf":false,"yoast_head":"\nTissue-Resident Macrophage Development and Function - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2021\/01\/28\/tissue-resident-macrophage-development-and-function\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tissue-Resident Macrophage Development and Function - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Karen Hirschi Citation: Wu Y, Hirschi KK. Tissue-Resident Macrophage Development and Function. Front Cell Dev Biol. 2021;8:617879. Published 2021 Jan 8. doi:10.3389\/fcell.2020.617879 DOI: https:\/\/doi.org\/10.3389\/fcell.2020.617879 Pub-Med Number: 33490082 Tissue-resident macrophages have been associated with important and diverse biological processes such as native immunity, tissue homeostasis and angiogenesis during development and postnatally. 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