{"id":107379,"date":"2021-07-02T11:12:02","date_gmt":"2021-07-02T15:12:02","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107379"},"modified":"2026-05-21T13:06:07","modified_gmt":"2026-05-21T17:06:07","slug":"mechanical-stretch-scales-centriole-number-to-apical-area-via-piezo1-in-multiciliated-cells","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2021\/07\/02\/mechanical-stretch-scales-centriole-number-to-apical-area-via-piezo1-in-multiciliated-cells\/","title":{"rendered":"Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells"},"content":{"rendered":"<p><strong>UVA Author:<\/strong> Saurabh Kulkarni<br \/>\n<strong>Citation:<\/strong> Kulkarni S, Marquez J, Date P, Ventrella R, Mitchell BJ, Khokha MK. Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells. Elife. 2021;10:e66076. Published 2021 Jun 29. doi:10.7554\/eLife.66076<\/p>\n<p><strong>DOI:<\/strong> <a>https:\/\/elifesciences.org\/articles\/66076#metrics<\/a><br \/>\n<strong>Pub-Med Number<\/strong>: 34184636<\/p>\n<hr \/>\n<p>How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to assemble multiple cilia. Aberration in centriole\/cilia number impairs MCC function and can lead to pathological outcomes. Yet how MCCs control centriole number remains unknown. Using <i>Xenopus<\/i>, we demonstrate that centriole number scales with apical area over a remarkable 40-fold change in size. We find that tensile forces that shape the apical area also trigger centriole amplification based on both cell stretching experiments and disruption of embryonic elongation. Unexpectedly, Piezo1, a mechanosensitive ion channel, localizes near each centriole suggesting a potential role in centriole amplification. Indeed, depletion of Piezo1 affects centriole amplification and disrupts its correlation with the apical area in a tension dependent manner. Thus, mechanical forces calibrate cilia\/centriole number to the MCC apical area via Piezo1. Our results provide new perspectives to study organelle number control essential for optimal cell function.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>UVA Author: Saurabh Kulkarni Citation: Kulkarni S, Marquez J, Date P, Ventrella R, Mitchell BJ, Khokha MK. Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells. Elife. 2021;10:e66076. Published 2021 Jun 29. doi:10.7554\/eLife.66076 DOI: https:\/\/elifesciences.org\/articles\/66076#metrics Pub-Med Number: 34184636 How cells count and regulate organelle number is a fundamental question in cell [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[21],"class_list":["post-107379","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-delete"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2021\/07\/02\/mechanical-stretch-scales-centriole-number-to-apical-area-via-piezo1-in-multiciliated-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Saurabh Kulkarni Citation: Kulkarni S, Marquez J, Date P, Ventrella R, Mitchell BJ, Khokha MK. Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells. Elife. 2021;10:e66076. 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Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells. Elife. 2021;10:e66076. 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