{"id":107385,"date":"2022-04-20T11:12:01","date_gmt":"2022-04-20T15:12:01","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107385"},"modified":"2025-05-15T11:28:51","modified_gmt":"2025-05-15T15:28:51","slug":"lysosomes-to-the-rescue-anterograde-axonal-lysosome-transport-and-neuronal-proteostasis","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2022\/04\/20\/lysosomes-to-the-rescue-anterograde-axonal-lysosome-transport-and-neuronal-proteostasis\/","title":{"rendered":"Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis"},"content":{"rendered":"<p><strong>UVA Author:<\/strong> Chan Choo Yap<br \/>\n<strong>Citation:<\/strong> Yap CC, Winckler B. Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis. Dev Cell. 2021;56(10):1361-1362. doi:10.1016\/j.devcel.2021.04.024<\/p>\n<p><strong>DOI:<\/strong> <a>https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1534580721003622?via%3Dihub<\/a><br \/>\n<strong>Pub-Med Number<\/strong>: 34004149<\/p>\n<hr \/>\n<div id=\"abstract\" class=\"abstract\">\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p>Niemann-Pick is a lysosomal storage disease caused by loss of the lysosomal cholesterol exporter NPC1 and leads to axon degeneration. Roney et al. report that immature autophagosomes accumulate in axons because cholesterol-laden lysosomes in the soma are not transported to the axon for autophagosome fusion and maturation because they aberrantly sequester non-functioning kinesin-1.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>UVA Author: Chan Choo Yap Citation: Yap CC, Winckler B. Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis. Dev Cell. 2021;56(10):1361-1362. doi:10.1016\/j.devcel.2021.04.024 DOI: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1534580721003622?via%3Dihub Pub-Med Number: 34004149 Niemann-Pick is a lysosomal storage disease caused by loss of the lysosomal cholesterol exporter NPC1 and leads to axon degeneration. Roney et al. report that [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[],"class_list":["post-107385","post","type-post","status-publish","format-standard","hentry","category-featured-publications"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2022\/04\/20\/lysosomes-to-the-rescue-anterograde-axonal-lysosome-transport-and-neuronal-proteostasis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Chan Choo Yap Citation: Yap CC, Winckler B. Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis. Dev Cell. 2021;56(10):1361-1362. doi:10.1016\/j.devcel.2021.04.024 DOI: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1534580721003622?via%3Dihub Pub-Med Number: 34004149 Niemann-Pick is a lysosomal storage disease caused by loss of the lysosomal cholesterol exporter NPC1 and leads to axon degeneration. 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