{"id":107395,"date":"2022-04-21T15:19:06","date_gmt":"2022-04-21T19:19:06","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107395"},"modified":"2026-05-21T14:14:15","modified_gmt":"2026-05-21T18:14:15","slug":"convergent-extension-in-mammalian-morphogenesis","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2022\/04\/21\/convergent-extension-in-mammalian-morphogenesis\/","title":{"rendered":"Convergent extension in mammalian morphogenesis"},"content":{"rendered":"

UVA Author:<\/strong> Ann Sutherland
\nCitation:<\/strong> Sutherland A, Keller R, Lesko A. Convergent extension in mammalian morphogenesis. Semin Cell Dev Biol. 2020;100:199-211. doi:10.1016\/j.semcdb.2019.11.002<\/p>\n

DOI:<\/strong> https:\/\/doi.org\/10.1016\/j.semcdb.2019.11.002<\/a>
\nPub-Med Number<\/strong>: 31734039<\/p>\n

\n
\n

Convergent extension is a fundamental morphogenetic process that underlies not only the generation of the elongated vertebrate body plan from the initially radially symmetrical embryo, but also the specific shape changes characteristic of many individual tissues. These tissue shape changes are the result of specific cell behaviors, coordinated in time and space, and affected by the physical properties of the tissue. While mediolateral cell intercalation is the classic cellular mechanism for producing tissue convergence and extension, other cell behaviors can also provide similar tissue-scale distortions or can modulate the effects of mediolateral cell intercalation to sculpt a specific shape. Regulation of regional tissue morphogenesis through planar polarization of the variety of underlying cell behaviors is well-recognized, but as yet is not well understood at the molecular level. Here, we review recent advances in understanding the cellular basis for convergence and extension and its regulation.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

UVA Author: Ann Sutherland Citation: Sutherland A, Keller R, Lesko A. Convergent extension in mammalian morphogenesis. Semin Cell Dev Biol. 2020;100:199-211. doi:10.1016\/j.semcdb.2019.11.002 DOI: https:\/\/doi.org\/10.1016\/j.semcdb.2019.11.002 Pub-Med Number: 31734039 Convergent extension is a fundamental morphogenetic process that underlies not only the generation of the elongated vertebrate body plan from the initially radially symmetrical embryo, but also the […]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[21],"class_list":["post-107395","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-delete"],"acf":false,"yoast_head":"\nConvergent extension in mammalian morphogenesis - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2022\/04\/21\/convergent-extension-in-mammalian-morphogenesis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Convergent extension in mammalian morphogenesis - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Ann Sutherland Citation: Sutherland A, Keller R, Lesko A. Convergent extension in mammalian morphogenesis. Semin Cell Dev Biol. 2020;100:199-211. doi:10.1016\/j.semcdb.2019.11.002 DOI: https:\/\/doi.org\/10.1016\/j.semcdb.2019.11.002 Pub-Med Number: 31734039 Convergent extension is a fundamental morphogenetic process that underlies not only the generation of the elongated vertebrate body plan from the initially radially symmetrical embryo, but also the […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/cell-biology\/2022\/04\/21\/convergent-extension-in-mammalian-morphogenesis\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-21T19:19:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-21T18:14:15+00:00\" \/>\n<meta name=\"author\" content=\"zkr7e@virginia.edu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"zkr7e@virginia.edu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/convergent-extension-in-mammalian-morphogenesis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/convergent-extension-in-mammalian-morphogenesis\\\/\"},\"author\":{\"name\":\"zkr7e@virginia.edu\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#\\\/schema\\\/person\\\/b4929a1d4683383a392718e12166cd7f\"},\"headline\":\"Convergent extension in mammalian morphogenesis\",\"datePublished\":\"2022-04-21T19:19:06+00:00\",\"dateModified\":\"2026-05-21T18:14:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/convergent-extension-in-mammalian-morphogenesis\\\/\"},\"wordCount\":181,\"keywords\":[\"Delete\"],\"articleSection\":[\"Featured Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/convergent-extension-in-mammalian-morphogenesis\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/convergent-extension-in-mammalian-morphogenesis\\\/\",\"name\":\"Convergent extension in mammalian morphogenesis - 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