{"id":107400,"date":"2022-04-21T15:34:39","date_gmt":"2022-04-21T19:34:39","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107400"},"modified":"2026-05-21T12:42:05","modified_gmt":"2026-05-21T16:42:05","slug":"understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2022\/04\/21\/understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes\/","title":{"rendered":"Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes"},"content":{"rendered":"

UVA Author:<\/strong> Nafiisha Genet
\nCitation:<\/strong> Genet N, Hirschi KK. Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes. Regen Med. 2021;16(9):861-870. doi:10.2217\/rme-2021-0022<\/p>\n

DOI:<\/strong> https:\/\/doi.org\/10.2217\/rme-2021-0022<\/a>
\nPub-Med Number<\/strong>: 34498495<\/p>\n

\n
\n

The use of neural stem cell (NSC) therapy for the treatment of stroke patients is successfully paving its way into advanced phases of large-scale clinical trials. To understand how to optimize NSC therapeutic approaches, it is fundamental to decipher the crosstalk between NSC and other cells that comprise the NSC microenvironment (niche)\u00a0and regulate their function,\u00a0in vivo<\/em>; namely, the endothelial cells of the microvasculature. In this mini review, we first provide a concise summary of preclinical findings describing the signaling mechanisms between NSC and vascular endothelial cells\u00a0and\u00a0vice versa<\/em>. Second, we describe the progress made in the development of NSC therapy for the treatment of strokes.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

UVA Author: Nafiisha Genet Citation: Genet N, Hirschi KK. Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes. Regen Med. 2021;16(9):861-870. doi:10.2217\/rme-2021-0022 DOI: https:\/\/doi.org\/10.2217\/rme-2021-0022 Pub-Med Number: 34498495 The use of neural stem cell (NSC) therapy for the treatment of stroke patients is successfully paving its way into advanced […]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[21],"class_list":["post-107400","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-delete"],"acf":false,"yoast_head":"\nUnderstanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2022\/04\/21\/understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Nafiisha Genet Citation: Genet N, Hirschi KK. Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes. Regen Med. 2021;16(9):861-870. doi:10.2217\/rme-2021-0022 DOI: https:\/\/doi.org\/10.2217\/rme-2021-0022 Pub-Med Number: 34498495 The use of neural stem cell (NSC) therapy for the treatment of stroke patients is successfully paving its way into advanced […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/cell-biology\/2022\/04\/21\/understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-21T19:34:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-21T16:42:05+00:00\" \/>\n<meta name=\"author\" content=\"zkr7e@virginia.edu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"zkr7e@virginia.edu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes\\\/\"},\"author\":{\"name\":\"zkr7e@virginia.edu\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#\\\/schema\\\/person\\\/b4929a1d4683383a392718e12166cd7f\"},\"headline\":\"Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes\",\"datePublished\":\"2022-04-21T19:34:39+00:00\",\"dateModified\":\"2026-05-21T16:42:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes\\\/\"},\"wordCount\":163,\"keywords\":[\"Delete\"],\"articleSection\":[\"Featured Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2022\\\/04\\\/21\\\/understanding-neural-stem-cell-regulation-in-vivo-and-applying-the-insights-to-cell-therapy-for-strokes\\\/\",\"name\":\"Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes - 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