{"id":107404,"date":"2022-05-20T16:01:00","date_gmt":"2022-05-20T20:01:00","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107404"},"modified":"2026-05-21T13:52:01","modified_gmt":"2026-05-21T17:52:01","slug":"ecdysone-exerts-biphasic-control-of-regenerative-signaling-coordinating-the-completion-of-regeneration-with-developmental-progression","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2022\/05\/20\/ecdysone-exerts-biphasic-control-of-regenerative-signaling-coordinating-the-completion-of-regeneration-with-developmental-progression\/","title":{"rendered":"Ecdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression"},"content":{"rendered":"

UVA Author:<\/strong> Faith Karanja
\nCitation:<\/strong> Karanja F, Sahu S, Weintraub S, Bhandari R, Jaszczak R, Sitt J, Halme A. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2115017119. doi: 10.1073\/pnas.2115017119. PMID: 35086929; PMCID: PMC8812538.<\/p>\n

DOI:<\/strong> https:\/\/doi.org\/10.1073\/pnas.2115017119<\/a>
\nPub-Med Number<\/strong>: 35086929<\/p>\n

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In\u00a0Drosophila melanogaster<\/i>, loss of regenerative capacity in wing imaginal discs coincides with an increase in systemic levels of the steroid hormone ecdysone, a key coordinator of their developmental progression. Regenerating discs release the relaxin hormone Dilp8 (Drosophila<\/i>\u00a0insulin-like peptide 8) to limit ecdysone synthesis and extend the regenerative period. Here, we describe how regenerating tissues produce a biphasic response to ecdysone levels: lower concentrations of ecdysone promote local and systemic regenerative signaling, whereas higher concentrations suppress regeneration through the expression of\u00a0broad<\/i>\u00a0splice isoforms. Ecdysone also promotes the expression of\u00a0wingless<\/i>\u00a0during both regeneration and normal development through a distinct regulatory pathway. This dual role for ecdysone explains how regeneration can still be completed successfully in\u00a0dilp8\u2212<\/sup><\/i>mutant larvae: higher ecdysone levels increase the regenerative activity of tissues, allowing regeneration to reach completion in a shorter time. From these observations, we propose that ecdysone hormone signaling functions to coordinate regeneration with developmental progression.<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/section>\n
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UVA Author: Faith Karanja Citation: Karanja F, Sahu S, Weintraub S, Bhandari R, Jaszczak R, Sitt J, Halme A. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2115017119. doi: 10.1073\/pnas.2115017119. PMID: 35086929; PMCID: PMC8812538. DOI: https:\/\/doi.org\/10.1073\/pnas.2115017119 Pub-Med Number: 35086929 In\u00a0Drosophila melanogaster, loss of regenerative capacity in wing imaginal discs coincides with an increase in […]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[21],"class_list":["post-107404","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-delete"],"acf":false,"yoast_head":"\nEcdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2022\/05\/20\/ecdysone-exerts-biphasic-control-of-regenerative-signaling-coordinating-the-completion-of-regeneration-with-developmental-progression\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ecdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Faith Karanja Citation: Karanja F, Sahu S, Weintraub S, Bhandari R, Jaszczak R, Sitt J, Halme A. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2115017119. doi: 10.1073\/pnas.2115017119. PMID: 35086929; PMCID: PMC8812538. 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