{"id":107409,"date":"2023-04-18T16:36:45","date_gmt":"2023-04-18T20:36:45","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107409"},"modified":"2026-05-22T17:01:16","modified_gmt":"2026-05-22T21:01:16","slug":"hematopoietic-loss-of-y-chromosome-leads-to-cardiac-fibrosis-and-heart-failure-mortality","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/18\/hematopoietic-loss-of-y-chromosome-leads-to-cardiac-fibrosis-and-heart-failure-mortality\/","title":{"rendered":"Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality"},"content":{"rendered":"<p><strong>UVA Author:<\/strong> Chavkin NW<br \/>\n<strong>Citation:<\/strong> Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, Miura-Yura E, Zaghlool A, Evans MA, Fall T, De Hoyos HN, Sundstr\u00f6m J, Yura Y, Kour A, Arai Y, Thel MC, Arai Y, Mychaleckyj JC, Hirschi KK, Forsberg LA, Walsh K. Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. Science. 2022 Jul 15;377(6603):292-297. doi: 10.1126\/science.abn3100. Epub 2022 Jul 14. PMID: 35857592; PMCID: PMC9437978.<\/p>\n<p><strong>DOI:<\/strong> <a>https:\/\/pubmed.ncbi.nlm.nih.gov\/35857592\/<\/a><br \/>\n<strong>Pub-Med Number<\/strong>: 35857592<\/p>\n<hr \/>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p>Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic relationships have yet to be established. Here, we show that male mice reconstituted with bone marrow cells lacking the Y chromosome display increased mortality and age-related profibrotic pathologies including reduced cardiac function. Cardiac macrophages lacking the Y chromosome exhibited polarization toward a more fibrotic phenotype, and treatment with a transforming growth factor \u03b21-neutralizing antibody ameliorated cardiac dysfunction in mLOY mice. A prospective study revealed that mLOY in blood is associated with an increased risk for cardiovascular disease and heart failure-associated mortality. Together, these results indicate that hematopoietic mLOY causally contributes to fibrosis, cardiac dysfunction, and mortality in men.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>UVA Author: Chavkin NW Citation: Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, Miura-Yura E, Zaghlool A, Evans MA, Fall T, De Hoyos HN, Sundstr\u00f6m J, Yura Y, Kour A, Arai Y, Thel MC, Arai Y, Mychaleckyj JC, Hirschi KK, Forsberg LA, Walsh [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[22],"class_list":["post-107409","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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