{"id":107415,"date":"2023-04-21T15:14:27","date_gmt":"2023-04-21T19:14:27","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107415"},"modified":"2026-05-22T17:01:15","modified_gmt":"2026-05-22T21:01:15","slug":"connexin-43-mediated-neurovascular-interactions-regulate-neurogenesis-in-the-adult-brain-subventricular-zone","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/connexin-43-mediated-neurovascular-interactions-regulate-neurogenesis-in-the-adult-brain-subventricular-zone\/","title":{"rendered":"Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone"},"content":{"rendered":"<p><strong>UVA Author:<\/strong> Nafiisha Genet<br \/>\n<strong>Citation:<\/strong> Genet N, Genet G, Chavkin NW, Paila U, Fang JS, Vasavada HH, Goldberg JS, Acharya BR, Bhatt NS, Baker K, McDonnell SP, Huba M, Sankaranarayanan D, Ma GZM, Eichmann A, Thomas JL, Ffrench-Constant C, Hirschi KK. Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone. Cell Rep. 2023 Apr 11;42(4):112371. doi: 10.1016\/j.celrep.2023.112371. Epub ahead of print. PMID: 37043357.<\/p>\n<p><strong>DOI:<\/strong> <a>https:\/\/pubmed.ncbi.nlm.nih.gov\/37043357\/<\/a><br \/>\n<strong>Pub-Med Number<\/strong>: 37043357<\/p>\n<hr \/>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p>The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct interactions between NSCs and endothelial cells (ECs). Mechanisms by which direct NSC-EC interactions in the adult SVZ control NSC behavior are unclear. We found that Cx43 is highly expressed by SVZ NSCs and ECs, and its deletion in either leads to increased NSC proliferation and neuroblast generation, suggesting that Cx43-mediated NSC-EC interactions maintain NSC quiescence. This is further supported by single-cell RNA sequencing and in vitro studies showing that ECs control NSC proliferation by regulating expression of genes associated with NSC quiescence and\/or activation in a Cx43-dependent manner. Cx43 mediates these effects in a channel-independent manner involving its cytoplasmic tail and ERK activation. Such insights inform adult NSC regulation and maintenance aimed at stem cell therapies for neurodegenerative disorders.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>UVA Author: Nafiisha Genet Citation: Genet N, Genet G, Chavkin NW, Paila U, Fang JS, Vasavada HH, Goldberg JS, Acharya BR, Bhatt NS, Baker K, McDonnell SP, Huba M, Sankaranarayanan D, Ma GZM, Eichmann A, Thomas JL, Ffrench-Constant C, Hirschi KK. Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone. Cell Rep. [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[22],"class_list":["post-107415","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/connexin-43-mediated-neurovascular-interactions-regulate-neurogenesis-in-the-adult-brain-subventricular-zone\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Nafiisha Genet Citation: Genet N, Genet G, Chavkin NW, Paila U, Fang JS, Vasavada HH, Goldberg JS, Acharya BR, Bhatt NS, Baker K, McDonnell SP, Huba M, Sankaranarayanan D, Ma GZM, Eichmann A, Thomas JL, Ffrench-Constant C, Hirschi KK. Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone. Cell Rep. 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