{"id":107417,"date":"2023-04-21T15:52:25","date_gmt":"2023-04-21T19:52:25","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107417"},"modified":"2025-05-15T11:35:51","modified_gmt":"2025-05-15T15:35:51","slug":"spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/","title":{"rendered":"Spatial regulation of microtubule-dependent transport by septin GTPases"},"content":{"rendered":"

UVA Author:<\/strong> Elias Spiliotis
\nCitation:<\/strong> Spiliotis ET, Kesisova IA. Spatial regulation of microtubule-dependent transport by septin GTPases. Trends Cell Biol. 2021 Dec;31(12):979-993. doi: 10.1016\/j.tcb.2021.06.004. Epub 2021 Jul 9. PMID: 34253430; PMCID: PMC8595587.<\/p>\n

DOI:<\/strong> https:\/\/pubmed.ncbi.nlm.nih.gov\/34253430\/<\/a>
\nPub-Med Number<\/strong>: 34253430<\/p>\n

\n
\n

The intracellular long-range transport of membrane vesicles and organelles is mediated by microtubule motors (kinesins, dynein) which move cargo with spatiotemporal accuracy and efficiency. How motors navigate the microtubule network and coordinate their activity on membrane cargo are fundamental but poorly understood questions. New studies show that microtubule-dependent membrane traffic is spatially controlled by septins – a unique family of multimerizing GTPases that associate with microtubules and membrane organelles. We review how septins selectively regulate motor interactions with microtubules and membrane cargo. We posit that septins provide a novel traffic code that specifies the movement and directionality of select motor-cargo complexes on distinct microtubule tracks.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

UVA Author: Elias Spiliotis Citation: Spiliotis ET, Kesisova IA. Spatial regulation of microtubule-dependent transport by septin GTPases. Trends Cell Biol. 2021 Dec;31(12):979-993. doi: 10.1016\/j.tcb.2021.06.004. Epub 2021 Jul 9. PMID: 34253430; PMCID: PMC8595587. DOI: https:\/\/pubmed.ncbi.nlm.nih.gov\/34253430\/ Pub-Med Number: 34253430 The intracellular long-range transport of membrane vesicles and organelles is mediated by microtubule motors (kinesins, dynein) which move […]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[],"class_list":["post-107417","post","type-post","status-publish","format-standard","hentry","category-featured-publications"],"acf":false,"yoast_head":"\nSpatial regulation of microtubule-dependent transport by septin GTPases - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Spatial regulation of microtubule-dependent transport by septin GTPases - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Elias Spiliotis Citation: Spiliotis ET, Kesisova IA. Spatial regulation of microtubule-dependent transport by septin GTPases. Trends Cell Biol. 2021 Dec;31(12):979-993. doi: 10.1016\/j.tcb.2021.06.004. Epub 2021 Jul 9. PMID: 34253430; PMCID: PMC8595587. DOI: https:\/\/pubmed.ncbi.nlm.nih.gov\/34253430\/ Pub-Med Number: 34253430 The intracellular long-range transport of membrane vesicles and organelles is mediated by microtubule motors (kinesins, dynein) which move […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-21T19:52:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-15T15:35:51+00:00\" \/>\n<meta name=\"author\" content=\"zkr7e@virginia.edu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"zkr7e@virginia.edu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/\",\"url\":\"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/\",\"name\":\"Spatial regulation of microtubule-dependent transport by septin GTPases - Department of Cell Biology\",\"isPartOf\":{\"@id\":\"https:\/\/med.virginia.edu\/cell-biology\/#website\"},\"datePublished\":\"2023-04-21T19:52:25+00:00\",\"dateModified\":\"2025-05-15T15:35:51+00:00\",\"author\":{\"@id\":\"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/b4929a1d4683383a392718e12166cd7f\"},\"breadcrumb\":{\"@id\":\"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/med.virginia.edu\/cell-biology\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Spatial regulation of microtubule-dependent transport by septin GTPases\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/med.virginia.edu\/cell-biology\/#website\",\"url\":\"https:\/\/med.virginia.edu\/cell-biology\/\",\"name\":\"Department of Cell Biology\",\"description\":\"University of Virginia School of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/med.virginia.edu\/cell-biology\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/b4929a1d4683383a392718e12166cd7f\",\"name\":\"zkr7e@virginia.edu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g\",\"caption\":\"zkr7e@virginia.edu\"},\"url\":\"https:\/\/med.virginia.edu\/cell-biology\/author\/zkr7evirginia-edu\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Spatial regulation of microtubule-dependent transport by septin GTPases - Department of Cell Biology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/","og_locale":"en_US","og_type":"article","og_title":"Spatial regulation of microtubule-dependent transport by septin GTPases - Department of Cell Biology","og_description":"UVA Author: Elias Spiliotis Citation: Spiliotis ET, Kesisova IA. Spatial regulation of microtubule-dependent transport by septin GTPases. Trends Cell Biol. 2021 Dec;31(12):979-993. doi: 10.1016\/j.tcb.2021.06.004. Epub 2021 Jul 9. PMID: 34253430; PMCID: PMC8595587. DOI: https:\/\/pubmed.ncbi.nlm.nih.gov\/34253430\/ Pub-Med Number: 34253430 The intracellular long-range transport of membrane vesicles and organelles is mediated by microtubule motors (kinesins, dynein) which move […]","og_url":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/","og_site_name":"Department of Cell Biology","article_published_time":"2023-04-21T19:52:25+00:00","article_modified_time":"2025-05-15T15:35:51+00:00","author":"zkr7e@virginia.edu","twitter_card":"summary_large_image","twitter_misc":{"Written by":"zkr7e@virginia.edu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/","url":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/","name":"Spatial regulation of microtubule-dependent transport by septin GTPases - Department of Cell Biology","isPartOf":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/#website"},"datePublished":"2023-04-21T19:52:25+00:00","dateModified":"2025-05-15T15:35:51+00:00","author":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/b4929a1d4683383a392718e12166cd7f"},"breadcrumb":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/04\/21\/spatial-regulation-of-microtubule-dependent-transport-by-septin-gtpases\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/cell-biology\/"},{"@type":"ListItem","position":2,"name":"Spatial regulation of microtubule-dependent transport by septin GTPases"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/cell-biology\/#website","url":"https:\/\/med.virginia.edu\/cell-biology\/","name":"Department of Cell Biology","description":"University of Virginia School of Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/cell-biology\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/b4929a1d4683383a392718e12166cd7f","name":"zkr7e@virginia.edu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g","caption":"zkr7e@virginia.edu"},"url":"https:\/\/med.virginia.edu\/cell-biology\/author\/zkr7evirginia-edu\/"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/107417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/users\/1740"}],"replies":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/comments?post=107417"}],"version-history":[{"count":1,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/107417\/revisions"}],"predecessor-version":[{"id":107502,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/107417\/revisions\/107502"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/media?parent=107417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/categories?post=107417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/tags?post=107417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}