{"id":107426,"date":"2023-06-14T15:59:25","date_gmt":"2023-06-14T19:59:25","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107426"},"modified":"2026-05-22T17:01:13","modified_gmt":"2026-05-22T21:01:13","slug":"mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/","title":{"rendered":"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice"},"content":{"rendered":"<p><strong>UVA Author:<\/strong> Karen Hirschi<br \/>\n<strong>Citation:<\/strong> Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Sol\u00e1 P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell. 2023 May 25;186(11):2345-2360.e16. doi: 10.1016\/j.cell.2023.04.017. Epub 2023 May 10. PMID: 37167971; PMCID: PMC10225355.<\/p>\n<p><strong>DOI:<\/strong> <a>https:\/\/doi.org\/10.1016\/j.cell.2023.04.017<\/a><br \/>\n<strong>Pub-Med Number<\/strong>: 37167971<\/p>\n<hr \/>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p>A functional network of blood vessels is essential for organ growth and homeostasis, yet how the vasculature matures and maintains homeostasis remains elusive in live mice. By longitudinally tracking the same neonatal endothelial cells (ECs) over days to weeks, we found that capillary plexus expansion is driven by vessel regression to optimize network perfusion. Neonatal ECs rearrange positions to evenly distribute throughout the developing plexus and become positionally stable in adulthood. Upon local ablation, adult ECs survive through a plasmalemmal self-repair response, while neonatal ECs are predisposed to die. Furthermore, adult ECs reactivate migration to assist vessel repair. Global ablation reveals coordinated maintenance of the adult vascular architecture that allows for eventual network recovery. Lastly, neonatal remodeling and adult maintenance of the skin vascular plexus are orchestrated by temporally restricted, neonatal VEGFR2 signaling. Our work sheds light on fundamental mechanisms that underlie both vascular maturation and adult homeostasis in vivo.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>UVA Author: Karen Hirschi Citation: Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Sol\u00e1 P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell. 2023 May 25;186(11):2345-2360.e16. doi: 10.1016\/j.cell.2023.04.017. Epub 2023 May 10. PMID: 37167971; PMCID: PMC10225355. DOI: https:\/\/doi.org\/10.1016\/j.cell.2023.04.017 [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[22],"class_list":["post-107426","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Karen Hirschi Citation: Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Sol\u00e1 P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell. 2023 May 25;186(11):2345-2360.e16. doi: 10.1016\/j.cell.2023.04.017. Epub 2023 May 10. PMID: 37167971; PMCID: PMC10225355. DOI: https:\/\/doi.org\/10.1016\/j.cell.2023.04.017 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Cell Biology\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-14T19:59:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-22T21:01:13+00:00\" \/>\n<meta name=\"author\" content=\"zkr7e@virginia.edu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"zkr7e@virginia.edu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2023\\\/06\\\/14\\\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2023\\\/06\\\/14\\\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\\\/\"},\"author\":{\"name\":\"zkr7e@virginia.edu\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#\\\/schema\\\/person\\\/b4929a1d4683383a392718e12166cd7f\"},\"headline\":\"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice\",\"datePublished\":\"2023-06-14T19:59:25+00:00\",\"dateModified\":\"2026-05-22T21:01:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2023\\\/06\\\/14\\\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\\\/\"},\"wordCount\":223,\"keywords\":[\"Intranet\"],\"articleSection\":[\"Featured Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2023\\\/06\\\/14\\\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2023\\\/06\\\/14\\\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\\\/\",\"name\":\"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice - Department of Cell Biology\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#website\"},\"datePublished\":\"2023-06-14T19:59:25+00:00\",\"dateModified\":\"2026-05-22T21:01:13+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#\\\/schema\\\/person\\\/b4929a1d4683383a392718e12166cd7f\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2023\\\/06\\\/14\\\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2023\\\/06\\\/14\\\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/2023\\\/06\\\/14\\\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#website\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/\",\"name\":\"Department of Cell Biology\",\"description\":\"University of Virginia School of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/#\\\/schema\\\/person\\\/b4929a1d4683383a392718e12166cd7f\",\"name\":\"zkr7e@virginia.edu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g\",\"caption\":\"zkr7e@virginia.edu\"},\"url\":\"https:\\\/\\\/med.virginia.edu\\\/cell-biology\\\/author\\\/zkr7evirginia-edu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice - Department of Cell Biology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/","og_locale":"en_US","og_type":"article","og_title":"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice - Department of Cell Biology","og_description":"UVA Author: Karen Hirschi Citation: Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Sol\u00e1 P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell. 2023 May 25;186(11):2345-2360.e16. doi: 10.1016\/j.cell.2023.04.017. Epub 2023 May 10. PMID: 37167971; PMCID: PMC10225355. DOI: https:\/\/doi.org\/10.1016\/j.cell.2023.04.017 [&hellip;]","og_url":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/","og_site_name":"Department of Cell Biology","article_published_time":"2023-06-14T19:59:25+00:00","article_modified_time":"2026-05-22T21:01:13+00:00","author":"zkr7e@virginia.edu","twitter_card":"summary_large_image","twitter_misc":{"Written by":"zkr7e@virginia.edu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/#article","isPartOf":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/"},"author":{"name":"zkr7e@virginia.edu","@id":"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/b4929a1d4683383a392718e12166cd7f"},"headline":"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice","datePublished":"2023-06-14T19:59:25+00:00","dateModified":"2026-05-22T21:01:13+00:00","mainEntityOfPage":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/"},"wordCount":223,"keywords":["Intranet"],"articleSection":["Featured Publications"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/","url":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/","name":"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice - Department of Cell Biology","isPartOf":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/#website"},"datePublished":"2023-06-14T19:59:25+00:00","dateModified":"2026-05-22T21:01:13+00:00","author":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/b4929a1d4683383a392718e12166cd7f"},"breadcrumb":{"@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/cell-biology\/2023\/06\/14\/mechanisms-of-skin-vascular-maturation-and-maintenance-captured-by-longitudinal-imaging-of-live-mice\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/cell-biology\/"},{"@type":"ListItem","position":2,"name":"Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/cell-biology\/#website","url":"https:\/\/med.virginia.edu\/cell-biology\/","name":"Department of Cell Biology","description":"University of Virginia School of Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/cell-biology\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/med.virginia.edu\/cell-biology\/#\/schema\/person\/b4929a1d4683383a392718e12166cd7f","name":"zkr7e@virginia.edu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/eb05928a9c10d0bc86fc859e223e3e9cd7a535837367cf67c524db2a42f795d0?s=96&d=mm&r=g","caption":"zkr7e@virginia.edu"},"url":"https:\/\/med.virginia.edu\/cell-biology\/author\/zkr7evirginia-edu\/"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/107426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/users\/1740"}],"replies":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/comments?post=107426"}],"version-history":[{"count":1,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/107426\/revisions"}],"predecessor-version":[{"id":107511,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/posts\/107426\/revisions\/107511"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/media?parent=107426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/categories?post=107426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/med.virginia.edu\/cell-biology\/wp-json\/wp\/v2\/tags?post=107426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}