{"id":107430,"date":"2024-03-25T20:31:31","date_gmt":"2024-03-26T00:31:31","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107430"},"modified":"2026-05-22T17:01:12","modified_gmt":"2026-05-22T21:01:12","slug":"bone-marrow-endothelial-dysfunction-promotes-myeloid-cell-expansion-in-cardiovascular-disease","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2024\/03\/25\/bone-marrow-endothelial-dysfunction-promotes-myeloid-cell-expansion-in-cardiovascular-disease\/","title":{"rendered":"Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease"},"content":{"rendered":"<p><strong>UVA Author:<\/strong> Josh Wythe<br \/>\n<strong>Citation:<\/strong> Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann V, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Mu\u00f1oz-Guijosa C, Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, D\u00e9sog\u00e8re PA, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP, Naxerova K, Swirski FK, Nahrendorf M. Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. Nat Cardiovasc Res. 2022 Jan;1(1):28-44. doi: 10.1038\/s44161-021-00002-8. Epub 2021 Dec 23. PMID: 35747128; PMCID: PMC9216333.<\/p>\n<p><strong>DOI:<\/strong> <a>https:\/\/pubmed.ncbi.nlm.nih.gov\/35747128\/<\/a><br \/>\n<strong>Pub-Med Number<\/strong>: 35747128<\/p>\n<hr \/>\n<p>Abnormal hematopoiesis advances cardiovascular disease by generating excess inflammatory leukocytes that attack the arteries and the heart. The bone marrow niche regulates hematopoietic stem cell proliferation and hence the systemic leukocyte pool, but whether cardiovascular disease affects the hematopoietic organ&#8217;s microvasculature is unknown. Here we show that hypertension, atherosclerosis and myocardial infarction (MI) instigate endothelial dysfunction, leakage, vascular fibrosis and angiogenesis in the bone marrow, altogether leading to overproduction of inflammatory myeloid cells and systemic leukocytosis. Limiting angiogenesis with endothelial deletion of Vegfr2 (encoding vascular endothelial growth factor (VEGF) receptor 2) curbed emergency hematopoiesis after MI. We noted that bone marrow endothelial cells assumed inflammatory transcriptional phenotypes in all examined stages of cardiovascular disease. Endothelial deletion of Il6 or Vcan (encoding versican), genes shown to be highly expressed in mice with atherosclerosis or MI, reduced hematopoiesis and systemic myeloid cell numbers in these conditions. Our findings establish that cardiovascular disease remodels the vascular bone marrow niche, stimulating hematopoiesis and production of inflammatory leukocytes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>UVA Author: Josh Wythe Citation: Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann V, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Mu\u00f1oz-Guijosa C, Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[22],"class_list":["post-107430","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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