{"id":107431,"date":"2024-03-25T20:35:07","date_gmt":"2024-03-26T00:35:07","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107431"},"modified":"2026-05-22T17:01:12","modified_gmt":"2026-05-22T21:01:12","slug":"distinct-hypoxia-induced-translational-profiles-of-embryonic-and-adult-derived-macrophages","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2024\/03\/25\/distinct-hypoxia-induced-translational-profiles-of-embryonic-and-adult-derived-macrophages\/","title":{"rendered":"Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages"},"content":{"rendered":"<p><strong>UVA Author:<\/strong> Yinyu Wu<br \/>\n<strong>Citation:<\/strong> Wilcox NS, Yarovinsky TO, Pandya P, Ramgolam VS, Moro A, Wu Y, Nicoli S, Hirschi KK, Bender JR. Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages. iScience. 2023 Sep 21;26(12):107985. doi: 10.1016\/j.isci.2023.107985. PMID: 38047075; PMCID: PMC10690575.<\/p>\n<p><strong>DOI:<\/strong> <a>https:\/\/www.sciencedirect.com\/science\/article\/pii\/S258900422302062X?via%3Dihub<\/a><br \/>\n<strong>Pub-Med Number<\/strong>: 38047075<\/p>\n<hr \/>\n<p>Tissue resident macrophages are largely of embryonic (fetal liver) origin and long-lived, while bone marrow-derived macrophages (BMDM) are recruited following an acute perturbation, such as hypoxia in the setting of myocardial ischemia. Prior transcriptome analyses identified BMDM and fetal liver-derived macrophage (FLDM) differences at the RNA expression level. Posttranscriptional regulation determining mRNA stability and translation rate may override transcriptional signals in response to hypoxia. We profiled differentially regulated BMDM and FLDM transcripts in response to hypoxia at the level of mRNA translation. Using a translating ribosome affinity purification (TRAP) assay and RNA-seq, we identified non-overlapping transcripts with increased translation rate in BMDM (Ly6e, vimentin, PF4) and FLDM (Ccl7, Ccl2) after hypoxia. We further identified hypoxia-induced transcripts within these subsets that are regulated by the RNA-binding protein HuR. These findings define translational differences in macrophage subset gene expression programs, highlighting potential therapeutic targets in ischemic myocardium.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>UVA Author: Yinyu Wu Citation: Wilcox NS, Yarovinsky TO, Pandya P, Ramgolam VS, Moro A, Wu Y, Nicoli S, Hirschi KK, Bender JR. Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages. iScience. 2023 Sep 21;26(12):107985. doi: 10.1016\/j.isci.2023.107985. PMID: 38047075; PMCID: PMC10690575. DOI: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S258900422302062X?via%3Dihub Pub-Med Number: 38047075 Tissue resident macrophages are largely of embryonic (fetal [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[22],"class_list":["post-107431","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2024\/03\/25\/distinct-hypoxia-induced-translational-profiles-of-embryonic-and-adult-derived-macrophages\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Yinyu Wu Citation: Wilcox NS, Yarovinsky TO, Pandya P, Ramgolam VS, Moro A, Wu Y, Nicoli S, Hirschi KK, Bender JR. Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages. iScience. 2023 Sep 21;26(12):107985. doi: 10.1016\/j.isci.2023.107985. PMID: 38047075; PMCID: PMC10690575. 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Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages. iScience. 2023 Sep 21;26(12):107985. doi: 10.1016\/j.isci.2023.107985. PMID: 38047075; PMCID: PMC10690575. 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