{"id":107442,"date":"2025-05-13T18:09:28","date_gmt":"2025-05-13T22:09:28","guid":{"rendered":"https:\/\/med.virginia.edu\/cell-biology\/?p=107442"},"modified":"2026-05-22T17:01:06","modified_gmt":"2026-05-22T21:01:06","slug":"from-bench-to-bedside-murine-models-of-inherited-and-sporadic-brain-arteriovenous-malformations","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/cell-biology\/2025\/05\/13\/from-bench-to-bedside-murine-models-of-inherited-and-sporadic-brain-arteriovenous-malformations\/","title":{"rendered":"From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations"},"content":{"rendered":"<p><strong>UVA Author:<\/strong> Gael Genet<br \/>\n<strong>Citation:<\/strong> Ricciardelli AR, Genet G, Genet N, McClugage ST 3rd, Kan PT, Hirschi KK, Fish JE, Wythe JD. From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations. Angiogenesis. 2025 Feb 3;28(2):15. doi: 10.1007\/s10456-024-09953-5. PMID: 39899215; PMCID: PMC11790818.<\/p>\n<p><strong>DOI:<\/strong> <a>https:\/\/doi.org\/10.1007\/s10456-024-09953-5<\/a><br \/>\n<strong>Pub-Med Number<\/strong>: 39899215<\/p>\n<hr \/>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p>Brain arteriovenous malformations are abnormal vascular structures in which an artery shunts high pressure blood directly to a vein without an intervening capillary bed. These lesions become highly remodeled over time and are prone to rupture. Historically, brain arteriovenous malformations have been challenging to treat, using primarily surgical approaches. Over the past few decades, the genetic causes of these malformations have been uncovered. These can be divided into (1) familial forms, such as loss of function mutations in TGF-\u03b2 (BMP9\/10) components in hereditary hemorrhagic telangiectasia, or (2) sporadic forms, resulting from somatic gain of function mutations in genes involved in the RAS-MAPK signaling pathway. Leveraging these genetic discoveries, preclinical mouse models have been developed to uncover the mechanisms underlying abnormal vessel formation, and thus revealing potential therapeutic targets. Impressively, initial preclinical studies suggest that pharmacological treatments disrupting these aberrant pathways may ameliorate the abnormal pathologic vessel remodeling and inflammatory and hemorrhagic nature of these high-flow vascular anomalies. Intriguingly, these studies also suggest uncontrolled angiogenic signaling may be a major driver in bAVM pathogenesis. This comprehensive review describes the genetics underlying both inherited and sporadic bAVM and details the state of the field regarding murine models of bAVM, highlighting emerging therapeutic targets that may transform our approach to treating these devastating lesions.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>UVA Author: Gael Genet Citation: Ricciardelli AR, Genet G, Genet N, McClugage ST 3rd, Kan PT, Hirschi KK, Fish JE, Wythe JD. From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations. Angiogenesis. 2025 Feb 3;28(2):15. doi: 10.1007\/s10456-024-09953-5. PMID: 39899215; PMCID: PMC11790818. DOI: https:\/\/doi.org\/10.1007\/s10456-024-09953-5 Pub-Med Number: 39899215 Brain arteriovenous malformations are abnormal [&hellip;]<\/p>\n","protected":false},"author":1740,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13],"tags":[22],"class_list":["post-107442","post","type-post","status-publish","format-standard","hentry","category-featured-publications","tag-intranet"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations - Department of Cell Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/cell-biology\/2025\/05\/13\/from-bench-to-bedside-murine-models-of-inherited-and-sporadic-brain-arteriovenous-malformations\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations - Department of Cell Biology\" \/>\n<meta property=\"og:description\" content=\"UVA Author: Gael Genet Citation: Ricciardelli AR, Genet G, Genet N, McClugage ST 3rd, Kan PT, Hirschi KK, Fish JE, Wythe JD. From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations. Angiogenesis. 2025 Feb 3;28(2):15. doi: 10.1007\/s10456-024-09953-5. PMID: 39899215; PMCID: PMC11790818. 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