{"id":3296,"date":"2019-07-25T11:54:29","date_gmt":"2019-07-25T15:54:29","guid":{"rendered":"https:\/\/research.med.virginia.edu\/chrc\/?page_id=3296"},"modified":"2022-10-10T16:41:00","modified_gmt":"2022-10-10T16:41:00","slug":"klaus-rajewsky-lecture","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/chrc\/all-upcoming-seminars\/klaus-rajewsky-lecture\/","title":{"rendered":"Klaus Rajewsky, MD"},"content":{"rendered":"

2018 Betsy and Stuart Houston Lecture<\/strong><\/p>\n

November 7, 2018<\/strong><\/p>\n

Klaus Rajewsky, MD<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

\u201cTargeted mutagenesis and gene repair in modeling and controlling human lymphoid disorders<\/em>.\u201d<\/p>\n

 <\/p>\n

It was an honor to host our special guest here at UVA for the 3rd<\/sup> annual Betsy and Stuart Houston Lecture. Klaus Rajewsky, the head of the Immune Regulation and Cancer Group at the Max Delbr\u00fcck Center for Molecular Medicine, participated in a series of meetings and events leading up to his lecture. His lecture was very well attended, as the entire Medical Education Building Auditorium was full. Additionally, a live airing was available to attendees on-screen in a separate location.<\/p>\n

 <\/p>\n

The Making of a Scientist:<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

During Dr. Rajewsky\u2019s visit, he enjoyed a lunch with the Trainees and Junior Faculty, with the theme of the meeting is \u201cThe Making of a Scientist.\u201d The lunch was an open discussion with Dr. Rajewsky. The Professor displays a passion for teaching and learning. It is obvious that he loves his job and feeds off of his interactions with other scientists.<\/p>\n

 <\/p>\n

As UVA Researchers asked insightful questions, Dr. Rajewsky would respond with a lot of energy. His experiences that he shared remind us all that we are all learning at any stage of our lives. When asked about success and how to achieve the success that he has, he responded: \u201cby realizing when something does not work, and to move on to what may work and what does work.<\/em>\u201d<\/p>\n

 <\/p>\n

The Lecture:<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

Sponsored by the Child Health Research Center, the talk was entitled \u201cTargeted mutagenesis and gene repair in modeling and controlling human lymphoid disorders.\u201d Dr. R. Ariel Gomez, Director of the CHRC, was pleased with the attendance and excitement that this event brought.<\/p>\n

 <\/p>\n

Betsy and Stuart Houston provided the monetary gift to hold the 3rd<\/sup> annual Houston Lectureship. Although Betsy Houston, a previous patient of the UVA Medical Center, passed away in 2015, she and her husband provided a contribution prior to her death to support various Medical Center programs.\u00a0 The lectureship gives us the opportunity to invite an outstanding scientist to visit the University each year.<\/p>\n

 <\/p>\n

\u00a0The Reception and Dinner:\u00a0\u00a0\u00a0 <\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

We ended the day with an honorary dinner at the Alumni Hall\u2019s Jefferson Ballroom. The statue of Jefferson in Alumni Hall\u2019s Annex inspired our guest to refer to Jefferson and the rich history that UVA is part of as he delivered his speech.\u00a0 This venue provided the ideal ambiance to pay tribute to Dr. Rajewsky and to our generous contributors.<\/p>\n\n\n

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 <\/p>\n

Biography:<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

Our speaker Dr. Klaus Rajewsky is the head of the Immune Regulation and Cancer Group at the Max Delbr\u00fcck Center for Molecular Medicine. He has made fundamental contributions to our understanding of B cell development and function, and the mechanisms underlying B cell lymphomas. His current work continues to focus on better understanding B cell cancers and identifying ways to address them. In recognition of his work, he received numerous prestigious awards including:<\/p>\n

 <\/p>\n

1977 Avery-Landsteiner Prize<\/a><\/u> of the German Society for immunology<\/a><\/u><\/p>\n

1994 Behring Kitasato Prize<\/a><\/u> from the Hoechst Japan<\/a><\/u><\/p>\n

1996 Robert Koch Prize<\/a><\/u>, together with Fritz Melchers<\/a><\/u><\/p>\n

1997 K\u00f6rber Prize<\/a><\/u> for European Science<\/p>\n

2001 Deutscher Krebshilfepreis<\/a><\/u>, together with Martin-Leo Hansmann<\/a><\/u> and Ralf K\u00fcppers<\/a><\/u><\/p>\n

2004 Honorary degree<\/a><\/u> of the Johann Wolfgang Goethe University of Frankfurt am Main<\/a><\/u><\/p>\n

2005 Charles Rodolphe Brupbacher Prize<\/a><\/u> for Cancer Research, together with Mariano Barbacid<\/a><\/u><\/p>\n

2007 Novartis Prize for Basic Immunology<\/a><\/u>, together with Frederick Alt<\/a><\/u> and Fritz Melchers<\/a><\/u>\u00a0(de<\/a><\/u>)<\/p>\n

2008 Ernst Schering Prize<\/a><\/u><\/p>\n

2009 Max Delbr\u00fcck Medal<\/a><\/u><\/p>\n

2009 William B. Coley Award<\/a><\/u> for Distinguished Research in Tumor Immunology, together with Frederick Alt<\/a><\/u><\/p>\n

2010 Ernst Jung Gold Medal for Medicine<\/a><\/u><\/p>\n

 <\/p>\n

Klaus Rajewsky and his collaborators developed a general method of targeted mutagenesis in mouse embryonic stem cells by introducing bacteriophage- and yeast-derived recombination systems, which opened the way for conditional gene targeting. Using this and other novel approaches in their immunological work, they developed, together with NA Mitchison and NK Jerne, the antigen-bridge model of T-B cell cooperation, identified the B cell antigen receptor is a survival determinant of B cells, and characterized germinal centers as the sites of antibody somatic hypermutation and memory cell formation as well as the major source of human B cell lymphomas.\u00a0 The latter work included the identification of Hodgkin lymphoma as a germinal center-derived tumor.\u00a0 Over the last years, the work of his group has focused on mechanisms of microRNA control and the development of mouse models of human B cell lymphomas.<\/p>\n

 <\/p>\n

After postdoctoral work at the Institute Pasteur in Paris, Klaus Rajewsky built an immunology department at the Institute for Genetics at the University of Cologne, where he stayed for 38 years, with a part-time appointment as founding Program Coordinator of the EMBL Mouse Biology Program at Monterotondo near Rome in the later years.\u00a0 He then worked for 10 years at Harvard Medical School in Boston, USA, and is now at the Max-Delbru\u0308ck-Center for Molecular Medicine in Berlin, Germany.<\/p>\n

 <\/p>\n

Recent achievements include the identification of antagonizing PI3 Kinase and FOXO1 activities as key elements of germinal center B cell differentiation and their cooperativity in B cell lymphomagenesis. Additional new insights related to the mechanism of immune surveillance of Epstein-Barr-Virus (EBV) infected and transformed B cells, as well as various aspects of normal B cell development including its control by miRNAs.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

2018 Betsy and Stuart Houston Lecture November 7, 2018 Klaus Rajewsky, MD \u00a0 \u201cTargeted mutagenesis and gene repair in modeling and controlling human lymphoid disorders.\u201d   It was an honor to host our special guest here at UVA for the 3rd annual Betsy and Stuart Houston Lecture. Klaus Rajewsky, the head of the Immune Regulation […]<\/p>\n","protected":false},"author":1777,"featured_media":3321,"parent":1897,"menu_order":25,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-3296","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nKlaus Rajewsky, MD - Child Health Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/chrc\/all-upcoming-seminars\/klaus-rajewsky-lecture\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Klaus Rajewsky, MD - Child Health Research Center\" \/>\n<meta property=\"og:description\" content=\"2018 Betsy and Stuart Houston Lecture November 7, 2018 Klaus Rajewsky, MD \u00a0 \u201cTargeted mutagenesis and gene repair in modeling and controlling human lymphoid disorders.\u201d   It was an honor to host our special guest here at UVA for the 3rd annual Betsy and Stuart Houston Lecture. 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