{"id":3750,"date":"2020-11-13T13:50:45","date_gmt":"2020-11-13T17:50:45","guid":{"rendered":"https:\/\/research.med.virginia.edu\/chrc\/?p=3750"},"modified":"2026-06-10T15:43:48","modified_gmt":"2026-06-10T15:43:48","slug":"3750","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/","title":{"rendered":"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry"},"content":{"rendered":"

\"\"<\/p>\n

Child Health Research Center<\/strong><\/p>\n

John Bushweller, PhD<\/p>\n

\"\"<\/p>\n


\nProfessor, Molecular Physiology and Biological Physics Chemistry<\/em><\/p>\n

\u201cDecoding and Drugging Transcription Factor Fusion Drivers in Leukemia\u201d<\/em><\/strong><\/p>\n

ZOOM MEETING<\/em><\/strong><\/p>\n

Friday, November 13, 2020<\/em><\/strong><\/p>\n

Time 12:00pm – 1:00pm<\/em><\/strong><\/p>\n

Key messages\/learning objectives:<\/u><\/strong><\/p>\n

    \n
  1. Role of transcription factor fusions as drivers in leukemia<\/em><\/li>\n
  2. Mechanism of MLL-AF9 fusion in leukemia<\/em><\/li>\n
  3. Drug development targeting the CBFB-SMMHC fusion driver in leukemia<\/em><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Child Health Research Center John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry \u201cDecoding and Drugging Transcription Factor Fusion Drivers in Leukemia\u201d ZOOM MEETING Friday, November 13, 2020 Time 12:00pm – 1:00pm Key messages\/learning objectives: Role of transcription factor fusions as drivers in leukemia Mechanism of MLL-AF9 fusion in leukemia Drug development targeting the […]<\/p>\n","protected":false},"author":1777,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[8],"class_list":["post-3750","post","type-post","status-publish","format-standard","hentry","category-chrc-speaker-series","tag-intranet"],"acf":false,"yoast_head":"\nJohn Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry - Child Health Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry - Child Health Research Center\" \/>\n<meta property=\"og:description\" content=\"Child Health Research Center John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry \u201cDecoding and Drugging Transcription Factor Fusion Drivers in Leukemia\u201d ZOOM MEETING Friday, November 13, 2020 Time 12:00pm – 1:00pm Key messages\/learning objectives: Role of transcription factor fusions as drivers in leukemia Mechanism of MLL-AF9 fusion in leukemia Drug development targeting the […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/\" \/>\n<meta property=\"og:site_name\" content=\"Child Health Research Center\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-13T17:50:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-10T15:43:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.virginia.edu\/chrc\/wp-content\/uploads\/sites\/444\/2020\/06\/UVA.Childrens_RGB_Primary.png\" \/>\n\t<meta property=\"og:image:width\" content=\"3136\" \/>\n\t<meta property=\"og:image:height\" content=\"491\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"zrb8mf@virginia.edu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"zrb8mf@virginia.edu\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/\"},\"author\":{\"name\":\"zrb8mf@virginia.edu\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/#\\\/schema\\\/person\\\/37d06d0d7b2d42470a233568c39f02af\"},\"headline\":\"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry\",\"datePublished\":\"2020-11-13T17:50:45+00:00\",\"dateModified\":\"2026-06-10T15:43:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/\"},\"wordCount\":69,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/research.med.virginia.edu\\\/chrc\\\/files\\\/2020\\\/06\\\/UVA.Childrens_RGB_Primary.png\",\"keywords\":[\"Intranet\"],\"articleSection\":[\"CHRC Seminar Series\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/\",\"name\":\"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry - Child Health Research Center\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/research.med.virginia.edu\\\/chrc\\\/files\\\/2020\\\/06\\\/UVA.Childrens_RGB_Primary.png\",\"datePublished\":\"2020-11-13T17:50:45+00:00\",\"dateModified\":\"2026-06-10T15:43:48+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/#\\\/schema\\\/person\\\/37d06d0d7b2d42470a233568c39f02af\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/#primaryimage\",\"url\":\"https:\\\/\\\/research.med.virginia.edu\\\/chrc\\\/files\\\/2020\\\/06\\\/UVA.Childrens_RGB_Primary.png\",\"contentUrl\":\"https:\\\/\\\/research.med.virginia.edu\\\/chrc\\\/files\\\/2020\\\/06\\\/UVA.Childrens_RGB_Primary.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/2020\\\/11\\\/13\\\/3750\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/#website\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/\",\"name\":\"Child Health Research Center\",\"description\":\"Just another University of Virginia School of Medicine site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/#\\\/schema\\\/person\\\/37d06d0d7b2d42470a233568c39f02af\",\"name\":\"zrb8mf@virginia.edu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g\",\"caption\":\"zrb8mf@virginia.edu\"},\"url\":\"https:\\\/\\\/med.virginia.edu\\\/chrc\\\/author\\\/zrb8mfvirginia-edu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry - Child Health Research Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/","og_locale":"en_US","og_type":"article","og_title":"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry - Child Health Research Center","og_description":"Child Health Research Center John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry \u201cDecoding and Drugging Transcription Factor Fusion Drivers in Leukemia\u201d ZOOM MEETING Friday, November 13, 2020 Time 12:00pm – 1:00pm Key messages\/learning objectives: Role of transcription factor fusions as drivers in leukemia Mechanism of MLL-AF9 fusion in leukemia Drug development targeting the […]","og_url":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/","og_site_name":"Child Health Research Center","article_published_time":"2020-11-13T17:50:45+00:00","article_modified_time":"2026-06-10T15:43:48+00:00","og_image":[{"width":3136,"height":491,"url":"https:\/\/med.virginia.edu\/chrc\/wp-content\/uploads\/sites\/444\/2020\/06\/UVA.Childrens_RGB_Primary.png","type":"image\/png"}],"author":"zrb8mf@virginia.edu","twitter_card":"summary_large_image","twitter_misc":{"Written by":"zrb8mf@virginia.edu"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/#article","isPartOf":{"@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/"},"author":{"name":"zrb8mf@virginia.edu","@id":"https:\/\/med.virginia.edu\/chrc\/#\/schema\/person\/37d06d0d7b2d42470a233568c39f02af"},"headline":"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry","datePublished":"2020-11-13T17:50:45+00:00","dateModified":"2026-06-10T15:43:48+00:00","mainEntityOfPage":{"@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/"},"wordCount":69,"commentCount":0,"image":{"@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/#primaryimage"},"thumbnailUrl":"https:\/\/research.med.virginia.edu\/chrc\/files\/2020\/06\/UVA.Childrens_RGB_Primary.png","keywords":["Intranet"],"articleSection":["CHRC Seminar Series"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/","url":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/","name":"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry - Child Health Research Center","isPartOf":{"@id":"https:\/\/med.virginia.edu\/chrc\/#website"},"primaryImageOfPage":{"@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/#primaryimage"},"image":{"@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/#primaryimage"},"thumbnailUrl":"https:\/\/research.med.virginia.edu\/chrc\/files\/2020\/06\/UVA.Childrens_RGB_Primary.png","datePublished":"2020-11-13T17:50:45+00:00","dateModified":"2026-06-10T15:43:48+00:00","author":{"@id":"https:\/\/med.virginia.edu\/chrc\/#\/schema\/person\/37d06d0d7b2d42470a233568c39f02af"},"breadcrumb":{"@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/#primaryimage","url":"https:\/\/research.med.virginia.edu\/chrc\/files\/2020\/06\/UVA.Childrens_RGB_Primary.png","contentUrl":"https:\/\/research.med.virginia.edu\/chrc\/files\/2020\/06\/UVA.Childrens_RGB_Primary.png"},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/chrc\/2020\/11\/13\/3750\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/chrc\/"},{"@type":"ListItem","position":2,"name":"John Bushweller, PhD Professor, Molecular Physiology and Biological Physics Chemistry"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/chrc\/#website","url":"https:\/\/med.virginia.edu\/chrc\/","name":"Child Health Research Center","description":"Just another University of Virginia School of Medicine site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/chrc\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/med.virginia.edu\/chrc\/#\/schema\/person\/37d06d0d7b2d42470a233568c39f02af","name":"zrb8mf@virginia.edu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c54cc742455940b7fe64c0cbcc2f4e77eeac274cc9cd97879654d7793d2eda49?s=96&d=mm&r=g","caption":"zrb8mf@virginia.edu"},"url":"https:\/\/med.virginia.edu\/chrc\/author\/zrb8mfvirginia-edu\/"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/posts\/3750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/users\/1777"}],"replies":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/comments?post=3750"}],"version-history":[{"count":1,"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/posts\/3750\/revisions"}],"predecessor-version":[{"id":5904,"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/posts\/3750\/revisions\/5904"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/media?parent=3750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/categories?post=3750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/med.virginia.edu\/chrc\/wp-json\/wp\/v2\/tags?post=3750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}