Study focuses on role of microRNAs in ischemia-induced angiogenesis

A group of researchers including Charles Farber, PhD (CPHG) and Brian Annex, MD (Dept. of Medicine-Cardiovascular Medicine) have published findings from a study that explored the role of microRNAs in ischemia-induced angiogenesis, such as in peripheral arterial disease. The resulting data indicate that miR-93 enhances perfusion recovery from hindlimb ischemia and is a strong potential target for pharmacological modulation to promote angiogenesis in ischemic tissue. MicroRNA-93 Controls Perfusion Recovery After Hindlimb Ischemia by Modulating Expression of Multiple Genes in the Cell Cycle Pathway was published in the April 30, 2013 issue of Circulation.