{"id":3017,"date":"2023-03-17T13:03:25","date_gmt":"2023-03-17T17:03:25","guid":{"rendered":"https:\/\/med.virginia.edu\/diabetes-technology\/?p=3017"},"modified":"2026-07-10T18:06:02","modified_gmt":"2026-07-10T22:06:02","slug":"artificial-pancreas-developed-at-uva-improves-blood-sugar-control-for-kids-ages-2-6","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/diabetes-technology\/2023\/03\/17\/artificial-pancreas-developed-at-uva-improves-blood-sugar-control-for-kids-ages-2-6\/","title":{"rendered":"Artificial Pancreas Developed at UVA Improves Blood Sugar Control for Kids Ages 2-6"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-3020 size-full\" src=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2023\/03\/Screen-Shot-2023-03-17-at-12.04.52-PM.png\" alt=\"Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes\" width=\"612\" height=\"792\" srcset=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2023\/03\/Screen-Shot-2023-03-17-at-12.04.52-PM.png 612w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2023\/03\/Screen-Shot-2023-03-17-at-12.04.52-PM-232x300.png 232w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2023\/03\/Screen-Shot-2023-03-17-at-12.04.52-PM-155x200.png 155w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<h3><span data-contrast=\"auto\">An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology improves blood sugar control in children ages 2 to 6 with type 1 diabetes, according to a new study. Details of the clinical study and its findings were just published in the prestigious New England Journal of Medicine.<\/span><\/h3>\n<p><em>By: Eric Swenson, UVA Public Information Officer (ews3j@virginia.edu)<\/em><\/p>\n<p><em>CHARLOTTESVILLE, Va., March 16, 2023\u00a0<\/em><\/p>\n<p><span data-contrast=\"auto\">Trial participants using the artificial pancreas spent approximately <\/span><b><span data-contrast=\"auto\">three more hours per day<\/span><\/b><span data-contrast=\"auto\"> in their target blood sugar range compared with participants in a control group who continued relying on the methods they were already using to manage their blood sugar.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The Control-IQ system, manufactured by Tandem Diabetes Care, <\/span><span data-contrast=\"auto\">is a diabetes management device that <\/span><span data-contrast=\"auto\">automatically monitors and regulates blood glucose. The artificial pancreas has an insulin pump that uses advanced control algorithms based on the person\u2019s glucose-monitoring information to adjust the insulin dose as needed.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Based on findings from two earlier studies, the system has previously been approved by the U.S. Food and Drug Administration for people ages 6 and older with type 1 diabetes.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u201cAfter the resounding success of Control-IQ technology in people ages 6 and up, it is very rewarding to see our youngest patients, and often the most challenging patients to help, benefit as well,\u201d said Marc D. Breton, PhD, a UVA School of Medicine researcher who served as the trial\u2019s principal investigator and was recently honored as <\/span><a href=\"https:\/\/med.virginia.edu\/diabetes-technology\/2023\/01\/30\/innovator-of-year-marc-breton\/\"><span data-contrast=\"none\">UVA\u2019s 2022 Innovator of the Year<\/span><\/a><span data-contrast=\"auto\">. \u201cWith these results, we have now accumulated years of clinical validation of this system across all age groups and look forward to seeing this life-changing technology made available to the broadest possible population.\u201d<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Used During Everyday Life<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<div id=\"attachment_3025\" style=\"width: 310px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-3025\" class=\"size-medium wp-image-3025\" src=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2023\/03\/Screen-Shot-2023-03-17-at-12.17.19-PM-300x187.png\" alt=\"The Control-IQ artificial pancreas system was derived from research done at the Center for Diabetes Technology at the University of Virginia. Image credit: Tandem Diabetes Care\" width=\"300\" height=\"187\" srcset=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2023\/03\/Screen-Shot-2023-03-17-at-12.17.19-PM-300x187.png 300w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2023\/03\/Screen-Shot-2023-03-17-at-12.17.19-PM-321x200.png 321w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2023\/03\/Screen-Shot-2023-03-17-at-12.17.19-PM.png 720w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><p id=\"caption-attachment-3025\" class=\"wp-caption-text\">The Control-IQ artificial pancreas system was derived from research done at the Center for Diabetes Technology at the University of Virginia. Image credit: Tandem Diabetes Care<\/p><\/div>\n<p><span data-contrast=\"auto\">The study enrolled 102 children between ages 2 and 6 at three U.S. sites (UVA, Stanford University and the University of Colorado) and randomly assigned 68 of them to use the artificial pancreas system for 13 weeks, while the remaining 34 children were assigned to the control group. All participants maintained their regular daily routines during the study.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">On average, the time participants using the artificial pancreas spent within their target blood glucose range was about 12 percentage points higher than participants in the control group overall and 18 percentage points higher during the overnight hours of 10 p.m. to 6 a.m. Nighttime blood glucose control is particularly important, as severe, unchecked hypoglycemia (very low blood glucose levels) can lead to seizures, coma or even death.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Overall, the researchers found, participants were able to use the artificial pancreas safely. There were two cases of severe hypoglycemia in the artificial pancreas group, compared with one in the control group. There was also one case of diabetic ketoacidosis in the artificial pancreas group, caused by a failure of the thin plastic tube that connects the insulin pump to the patient\u2019s body.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Of note, most of the study-related visits \u2013 including 80% of the training sessions on the artificial pancreas and more than 90% of the overall visits \u2013 were conducted virtually. Achieving the reported results under these conditions highlights the ease of use of the technology and its potential for areas without easy access to endocrinologists.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u201cAt the end of the day, this technology significantly improved glycemia and ensured safety of our youngest patients, but perhaps just as importantly it lessened these families\u2019 constant anxiety about glucose levels, especially during the night.\u201d Breton said. \u201cIt is incredibly rewarding for us to hear about these families\u2019 experiences and how they manage to integrate these new tools in their life, offering some reprieve to the challenges they face.\u201d<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h5>News Coverage<\/h5>\n<p><a href=\"https:\/\/www.nbc29.com\/2023\/03\/16\/uva-artificial-pancreas-improving-blood-sugar-control-children-ages-2-6\/\">NBC29 News Broadcast<\/a><\/p>\n<p><a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/nih-supported-trial-shows-artificial-pancreas-improves-blood-glucose-control-young-children\">National Institute of Health News Release<\/a><\/p>\n<p><a href=\"https:\/\/www.cbs19news.com\/story\/48749691\/researchers-report-big-benefits-for-diabetes-patients-using-artificial-pancreas\">CBS19 News Broadcast<\/a><\/p>\n<p><a href=\"https:\/\/investor.tandemdiabetes.com\/node\/14416\/pdf\">Tandem Diabetes Care 3\/15\/23<\/a><\/p>\n<p><a href=\"https:\/\/investor.tandemdiabetes.com\/node\/14476\/pdf\">Tandem Diabetes Care 4\/17\/23<\/a><\/p>\n<p><a href=\"https:\/\/www.fiercebiotech.com\/medtech\/tandem-diabetes-care-cruises-fda-ok-toddler-use-automated-insulin-delivery-algorithm\">Fierce Biotech 11\/8\/23<\/a><\/p>\n<h5><b><span data-contrast=\"auto\">Findings Published<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h5>\n<p><span data-contrast=\"auto\">The study results have been published in the <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2210834?query=featured_home&amp;utm_campaign=research&amp;utm_content=news&amp;utm_medium=organic-social&amp;utm_source=twitter\">New England Journal of Medicin<\/a>e. The study\u2019s authors are R. Paul Wadwa, Zachariah W. Reed, Bruce A. Buckingham, Mark D. DeBoer, Laya Ekhlaspour, Gregory P. Forlenza, Melissa Schoelwer, John Lum, Craig Kollman, Roy W. Beck and Breton.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">This study was funded by the National Institutes of Health\u2019s National Institute of Diabetes and Digestive and Kidney Diseases, grant U01DK127551. Tandem Diabetes Care provided the investigational closed-loop systems used in the trial, while Dexcom, Inc. provided the continuous glucose monitor supplies used in the trial.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">For Reporters: <\/span><\/b><span data-contrast=\"auto\">Please email Eric Swensen at <\/span><span data-contrast=\"none\">ews3j@uvahealth.org<\/span><span data-contrast=\"auto\">. High-resolution photos are available.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology improves blood sugar control in children ages 2 to 6 with type 1 diabetes, according to a new study. Details of the clinical study and its findings were just published in the prestigious New England Journal of Medicine. By: Eric Swenson, [&hellip;]<\/p>\n","protected":false},"author":1866,"featured_media":3020,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[18],"tags":[23],"class_list":["post-3017","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cdt-news-articles","tag-department-news"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Artificial Pancreas Developed at UVA Improves Blood Sugar Control for Kids Ages 2-6 - Center for Diabetes Technology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/diabetes-technology\/2023\/03\/17\/artificial-pancreas-developed-at-uva-improves-blood-sugar-control-for-kids-ages-2-6\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Artificial Pancreas Developed at UVA Improves Blood Sugar Control for Kids Ages 2-6 - Center for Diabetes Technology\" \/>\n<meta property=\"og:description\" content=\"An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology improves blood sugar control in children ages 2 to 6 with type 1 diabetes, according to a new study. 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