{"id":3598,"date":"2024-10-03T09:56:40","date_gmt":"2024-10-03T13:56:40","guid":{"rendered":"https:\/\/med.virginia.edu\/diabetes-technology\/?p=3598"},"modified":"2024-10-03T09:58:07","modified_gmt":"2024-10-03T13:58:07","slug":"a-healthier-future-one-clinical-trial-at-a-time-an-interview-with-pediatric-endocrinologist-mark-deboer-md","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/diabetes-technology\/2024\/10\/03\/a-healthier-future-one-clinical-trial-at-a-time-an-interview-with-pediatric-endocrinologist-mark-deboer-md\/","title":{"rendered":"A Healthier Future \u2014 One Clinical Trial at a Time: An Interview With Pediatric Endocrinologist Mark DeBoer, MD"},"content":{"rendered":"<p><strong>By <a href=\"https:\/\/news.med.virginia.edu\/author\/jta6nvirginia-edu\/\">jta6n@virginia.edu<\/a><\/strong><\/p>\n<div id=\"attachment_3599\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-3599\" class=\"wp-image-3599 size-large\" src=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer_group-1024x683.webp\" alt=\"Group photo of 4 individuals on a clinical research team\" width=\"1024\" height=\"683\" srcset=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer_group-1024x683.webp 1024w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer_group-300x200.webp 300w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer_group-768x512.webp 768w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer_group.webp 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-3599\" class=\"wp-caption-text\">(From left) Mark DeBoer, MD, Principal Investigator; Dillon Flanagan, Data Operations Specialist; David Fulkerson, Data Analyst; and Lianna Smith, Clinical Research Coordinator. Not pictured: Marc Breton, PhD, Co-Principal Investigator<\/p><\/div>\n<p><strong>October 1, 2024 &#8211;<\/strong> Mark DeBoer, MD, is a pediatric endocrinologist and professor in the Department of Pediatrics at the UVA School of Medicine. He is passionate about improving the health of children and adolescents with Type 1 diabetes, with a particular interest in the development and testing of new diabetes technology. As a physician-scientist, Dr. DeBoer has collaborated with the UVA Center for Diabetes Technology for over 12 years conducting assessments of artificial pancreas systems in challenging pediatric situations such as during exercise, when not given insulin for food, and long-term home use.<\/p>\n<p>In this second installment of our series \u201cA Healthier Future \u2014 One Clinical Trial at a Time,\u201d Dr. DeBoer discusses his study titled, \u201cArtificial Pancreas \u2013 Adolescent Physiology and Psychology Longitudinal Evaluation.\u201d His goal for the study is to better understand the origins of difficult adolescent diabetes management, which may lead to future new treatments for Type 1 diabetes during puberty.<\/p>\n<h5>Q. What do you hope to learn in your study \u201cArtificial Pancreas \u2014 Adolescent Physiology and Psychology Longitudinal Evaluation?\u201d\u00a0 Will the results potentially change the standard of care for future patients?<\/h5>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3600 alignright\" src=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-300x169.webp\" alt=\"State of the art machine that reads blood glucose levels called a YSI\" width=\"300\" height=\"169\" srcset=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-300x169.webp 300w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-1024x576.webp 1024w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-768x432.webp 768w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-1536x864.webp 1536w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-450x253.webp 450w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-600x338.webp 600w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-740x416.webp 740w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-950x534.webp 950w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3-356x200.webp 356w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_3.webp 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>DeBoer:<\/strong>\u00a0It has been well documented that among patients with Type 1 diabetes, adolescents have the most difficult management of their blood sugars, with hemoglobin A1C values that spike in the early teen years to levels far above any other time in life. The reasons for this are likely diverse but may include changes in insulin resistance during puberty and changes parent-child dynamics and a shift in priorities, including an elevation in the importance of peer perceptions and relationships over other factors.<\/p>\n<p>In this study, we are following adolescents over a two-year period when HbA1c values have been known to spike, assessing insulin and glucose flux using state-of-the-art tracer techniques and assessing shifts in multiple aspects of psychology. Our findings may help Type 1 diabetes providers better understand the origins of difficult adolescent diabetes management that could help address and prevent these problems.<\/p>\n<h5>Q. Does your trial give novel treatment or other opportunities to your\/our patients?<\/h5>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3602 alignright\" src=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-300x169.webp\" alt=\"group of researchers having a discussion about an insulin pump\" width=\"300\" height=\"169\" srcset=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-300x169.webp 300w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-1024x576.webp 1024w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-768x432.webp 768w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-1536x864.webp 1536w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-450x253.webp 450w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-600x338.webp 600w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-740x416.webp 740w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-950x534.webp 950w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1-356x200.webp 356w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_1.webp 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>DeBoer:\u00a0<\/strong>For this study, we assess insulin resistance and glucose flux during yearly sessions in the Clinical Research Unit, where the adolescent receives three different glucose molecules labeled with stable (non-radioactive) isotopes, so that we can track these molecules and calculate multiple aspects of glucose dynamics that will help us follow for potential increases in insulin resistance during puberty and whether this resistance is more at the level of the liver or the periphery. This may guide future treatment approaches for Type 1 diabetes during puberty.<\/p>\n<h5><strong>Q.<\/strong>\u00a0What is novel about your study design, treatment, or intervention?<\/h5>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3601 alignright\" src=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-300x169.webp\" alt=\"Someone holding an insulin pump\" width=\"300\" height=\"169\" srcset=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-300x169.webp 300w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-1024x576.webp 1024w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-768x432.webp 768w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-1536x864.webp 1536w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-450x253.webp 450w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-600x338.webp 600w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-740x416.webp 740w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-950x534.webp 950w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2-356x200.webp 356w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_2.webp 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>DeBoer:<\/strong>\u00a0We are one of the only centers in the world able to perform these triple-labeled glucose flux studies, with detailed analysis of how insulin resistance might change over the course of puberty. Our assessments of psychological changes over the course of puberty will also provide novel insights on how these changes are related to potential worsening diabetes management during these transitional years.<\/p>\n<h5>Q. How do you ensure inclusion of a diverse subject population?<\/h5>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3603 alignright\" src=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-300x169.webp\" alt=\"group of researchers discussing the lab results of the YSI machine\" width=\"300\" height=\"169\" srcset=\"https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-300x169.webp 300w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-1024x576.webp 1024w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-768x432.webp 768w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-1536x864.webp 1536w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-450x253.webp 450w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-600x338.webp 600w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-740x416.webp 740w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-950x534.webp 950w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4-356x200.webp 356w, https:\/\/med.virginia.edu\/diabetes-technology\/wp-content\/uploads\/sites\/265\/2024\/10\/DeBoer-Photos_4.webp 2048w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>DeBoer:<\/strong>\u00a0We have been able to recruit under-represented minorities to this study by making this a priority in contacting families about potential participation. This is especially important in a study in Type 1 diabetes, which is a disease that has racial\/ethnic differences in its prevalence, with a much higher proportion of non-Hispanic white individuals among those who are affected.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>By jta6n@virginia.edu October 1, 2024 &#8211; Mark DeBoer, MD, is a pediatric endocrinologist and professor in the Department of Pediatrics at the UVA School of Medicine. He is passionate about improving the health of children and adolescents with Type 1 diabetes, with a particular interest in the development and testing of new diabetes technology. As [&hellip;]<\/p>\n","protected":false},"author":1866,"featured_media":3601,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[18],"tags":[],"class_list":["post-3598","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cdt-news-articles"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A Healthier Future \u2014 One Clinical Trial at a Time: An Interview With Pediatric Endocrinologist Mark DeBoer, MD - Center for Diabetes Technology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/diabetes-technology\/2024\/10\/03\/a-healthier-future-one-clinical-trial-at-a-time-an-interview-with-pediatric-endocrinologist-mark-deboer-md\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Healthier Future \u2014 One Clinical Trial at a Time: An Interview With Pediatric Endocrinologist Mark DeBoer, MD - Center for Diabetes Technology\" \/>\n<meta property=\"og:description\" content=\"By jta6n@virginia.edu October 1, 2024 &#8211; Mark DeBoer, MD, is a pediatric endocrinologist and professor in the Department of Pediatrics at the UVA School of Medicine. 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