Ananda Basu and Rita Basu

ABOUT THE LAB

The Integrated Carbohydrate Physiology and Translation Laboratory of Ananda Basu, M.B.B.S., M.D., and Rita Basu, M.D., focuses on understanding the integrative physiology of glucose metabolism in people with diabetes and people without diabetes.

The Integrated Carbohydrate Physiology and Translation Lab, which is based at the University of Virginia, has several diabetes-related research interests, including:

  • The pathophysiology of prediabetes, type 1 diabetes, type 2 diabetes and hypoglycemia
  • The role of excess cortisol and carotid bodies in regulating blood glucose in people with and without diabetes
  • The biology of metabolic syndrome
  • Understanding subcutaneous glucose transport and continuous subcutaneous glucose sensing in type 1 diabetes
  • Accelerating closed-loop control for the development of an artificial pancreas for type 1 diabetes that will deliver insulin automatically and with an individualized precision never before possible

The long-term goal of the research team of Drs. Ananda Basu and Rita Basu is to develop rational and effective therapies for the treatment and prevention of diabetes mellitus and its associated complications.

The Integrated Carbohydrate Physiology and Translation Lab research team uses stable and radioactive isotopes, organ catheterization (hepatic, leg and forearm) and mathematical models to answer research questions.

The team assesses the impact of physiological changes in glucose, insulin, glucagon, cortisol, incretins and various substrates (such as free fatty acids) on carbohydrate, fat and protein metabolism in people with diabetes and people without diabetes.

This line of investigation was pioneered by Robert A. Rizza, M.D., of Mayo Clinic. In the late 1970s and early 1980s, Dr. Rizza conducted experiments with inpatient clinical research-based IV insulin Biostator — the first artificial pancreas.

The Integrated Carbohydrate Physiology and Translation Lab also studies novel aspects of type 2 diabetes and prediabetes.

Research is directed at developing physiological models to inform, fine-tune and eventually personalize an effective closed-loop control artificial pancreas system for patients with type 1 diabetes using cutting-edge insulin pump and glucose sensor technologies.

Other programs are related to defining the role of carotid bodies in the regulation of blood glucose in humans with and without diabetes and obstructive sleep apnea, and the role of cortisol in modulating liver glucose metabolism in obesity and diabetes.

 

Research Funding

  • NIH/NIDDK R01 DK08551609 (9/15/2017 – 4/30/2022): Integrated approaches to close the loop in type 1 diabetes
  • NIH/NIDDK DP3 DK10678502 (12/20/2017 – 8/31/2020): Relative efficacy of single-, bi-, and tri-hormonal closed loop control systems
  • NIH/NIDDK R01 DK02995337 (8/1/2019 – 7/31/2024): Mechanisms of insulin resistance in man
  • AstraZeneca: Does inhibition of liver specific 11B-hydroxysteroid dehydrogenase type 1 enzyme lower liver fat in NASH?

 

Publications

Basu A, Yadav Y, Carter RE, Basu R, Novel Insights Into Effects of Cortisol and Glucagon on Nocturnal Glucose Production in Type 2 Diabetes., 2020; The Journal of clinical endocrinology and metabolism. 105(7) . PMID: 32374825 | PMCID: PMC7274493

Romeres D, Olson K, Carter R, Cobelli C, Dalla Man C, Basu A, Basu R, Hyperglycemia But Not Hyperinsulinemia Is Favorable for Exercise in Type 1 Diabetes: A Pilot Study., 2020; Diabetes care. () . PMID: 32661106

Keenan DM, Veldhuis JD, Basu A, Basu R, A novel measure of glucose homeostasis (or loss thereof) comprising the joint dynamics of glucose, insulin, glucagon, and cortisol., 2019; American journal of physiology. Endocrinology and metabolism. 316(6) E998-E1011. PMID: 30860881 | PMCID: PMC6620575

Basu R, Schiavon M, Petterson XM, Hinshaw L, Slama M, Carter R, Man CD, Cobelli C, Basu A, A novel natural tracer method to measure complex carbohydrate metabolism., 2019; American journal of physiology. Endocrinology and metabolism. 317(3) E483-E493. PMID: 31265327 | PMCID: PMC6766609

Brown SA, Basu A, Kovatchev BP, Beyond HbA1c : using continuous glucose monitoring metrics to enhance interpretation of treatment effect and improve clinical decision-making., 2019; Diabetic medicine : a journal of the British Diabetic Association. 36(6) 679-687. PMID: 30848545

Basu A, Joshi N, Miles J, Carter RE, Rizza RA, Basu R, Paradigm Shifts in Nocturnal Glucose Control in Type 2 Diabetes., 2018; The Journal of clinical endocrinology and metabolism. 103(10) 3801-3809. PMID: 30020503 | PMCID: PMC6179178

Frank S, Jbaily A, Hinshaw L, Basu R, Basu A, Szeri AJ, Modeling the acute effects of exercise on insulin kinetics in type 1 diabetes., 2018; Journal of pharmacokinetics and pharmacodynamics. 45(6) 829-845. PMID: 30392154

Ozaslan B, Patek SD, Grabman JH, Shepard JA, Dassau E, Breton MD, Kudva YC, Brown SA, Basu A, Pinsker JE, Doyle FJ, Gonder-Frederick L, Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes., 2018; Journal of diabetes science and technology. 12(3) 657-664. PMID: 29415563 | PMCID: PMC6154247

Basu A, Pieber TR, Hansen AK, Sach-Friedl S, Erichsen L, Basu R, Haahr H, Greater early postprandial suppression of endogenous glucose production and higher initial glucose disappearance is achieved with fast-acting insulin aspart compared with insulin aspart., 2018; Diabetes, obesity & metabolism. 20(7) 1615-1622. PMID: 29493118 | PMCID: PMC6033168

Tan AWK, Subaran SC, Sauder MA, Chai W, Jahn LA, Fowler DE, Patrie JT, Aylor KW, Basu A, Liu Z, GLP-1 and Insulin Recruit Muscle Microvasculature and Dilate Conduit Artery Individually But Not Additively in Healthy Humans., 2018; Journal of the Endocrine Society. 2(2) 190-206. PMID: 29568814 | PMCID: PMC5841186

Brown SA, Breton MD, Anderson SM, Kollar L, Keith-Hynes P, Levy CJ, Lam DW, Levister C, Baysal N, Kudva YC, Basu A, Dadlani V, Hinshaw L, McCrady-Spitzer S, Bruttomesso D, Visentin R, Galasso S, Favero SD, Leal Y, Boscari F, Avogaro A, Cobelli C, Kovatchev BP, Overnight Closed Loop Control Improves Glycemic Control in a Multicenter Study of Adults with Type 1 Diabetes., 2017; The Journal of clinical endocrinology and metabolism. () . PMID: 28666360 | PMCID: PMC5630248

Dassau E, Pinsker JE, Kudva YC, Brown SA, Gondhalekar R, Dalla Man C, Patek S, Schiavon M, Dadlani V, Dasanayake I, Church MM, Carter RE, Bevier WC, Huyett LM, Hughes J, Anderson S, Lv D, Schertz E, Emory E, McCrady-Spitzer SK, Jean T, Bradley PK, Hinshaw L, Laguna Sanz AJ, Basu A, Kovatchev B, Cobelli C, Doyle FJ, 12-Week 24/7 Ambulatory Artificial Pancreas With Weekly Adaptation of Insulin Delivery Settings: Effect on Hemoglobin A1c and Hypoglycemia., 2017; Diabetes care. () . PMID: 29030383 | PMCID: PMC5711334

Basu A, Importance of Artificial Pancreas Standard Nomenclature., 2017; Diabetes technology & therapeutics. 19(6) 323. PMID: 28613949

Basu A, Slama MQ, Nicholson WT, Langman L, Peyser T, Carter R, Basu R, Continuous Glucose Monitor Interference With Commonly Prescribed Medications: A Pilot Study., 2017; Journal of diabetes science and technology. 11(5) 936-941. PMID: 28332406

Errazuriz I, Dube S, Slama M, Visentin R, Nayar S, O’Connor H, Cobelli C, Das SK, Basu A, Kremers WK, Port J, Basu R, Randomized Controlled Trial of a MUFA or Fiber-Rich Diet on Hepatic Fat in Prediabetes., 2017; The Journal of clinical endocrinology and metabolism. 102(5) 1765-1774. PMID: 28323952 | PMCID: PMC5443322

Basu A, Dube S, Basu R, Men Are from Mars, Women Are from Venus: Sex Differences in Insulin Action and Secretion., 2017; Advances in experimental medicine and biology. 1043() 53-64. PMID: 29224090

Basu A, Veettil S, Dyer R, Peyser T, Basu R, Direct Evidence of Acetaminophen Interference with Subcutaneous Glucose Sensing in Humans: A Pilot Study., 2016; Diabetes technology & therapeutics. 18() S243-7. PMID: 26784129 | PMCID: PMC4717519

Hinshaw L, Schiavon M, Dadlani V, Mallad A, Dalla Man C, Bharucha A, Basu R, Geske JR, Carter RE, Cobelli C, Basu A, Kudva YC, Effect of Pramlintide on Postprandial Glucose Fluxes in Type 1 Diabetes., 2016; The Journal of clinical endocrinology and metabolism. 101(5) 1954-62. PMID: 26930181 | PMCID: PMC4870844

Gonder-Frederick LA, Grabman JH, Kovatchev B, Brown SA, Patek S, Basu A, Pinsker JE, Kudva YC, Wakeman CA, Dassau E, Cobelli C, Zisser HC, Doyle FJ, Is Psychological Stress a Factor for Incorporation Into Future Closed-Loop Systems?, 2016; Journal of diabetes science and technology. 10(3) 640-6. PMID: 26969142 | PMCID: PMC5038545

Cobelli C, Schiavon M, Dalla Man C, Basu A, Basu R, Interstitial Fluid Glucose Is Not Just a Shifted-in-Time but a Distorted Mirror of Blood Glucose: Insight from an In Silico Study., 2016; Diabetes technology & therapeutics. 18(8) 505-11. PMID: 27253751 | PMCID: PMC4991590

Parthasarathy G, Kudva YC, Low PA, Camilleri M, Basu A, Bharucha AE, Relationship Between Gastric Emptying and Diurnal Glycemic Control in Type 1 Diabetes Mellitus: A Randomized Trial., 2016; The Journal of clinical endocrinology and metabolism. 102(2) 398-406. PMID: 27880079 | PMCID: PMC5413165

Dassau E, Brown SA, Basu A, Pinsker JE, Kudva YC, Gondhalekar R, Patek S, Lv D, Schiavon M, Lee JB, Man CD, Hinshaw L, Castorino K, Mallad A, Dadlani V, McCrady-Spitzer SK, McElwee-Malloy M, Wakeman CA, Bevier WC, Bradley PK, Kovatchev B, Cobelli C, Zisser HC, Doyle FJ, Adjustment of Open-Loop Settings to Improve Closed-Loop Results in Type 1 Diabetes: A Multicenter Randomized Trial., 2015; The Journal of clinical endocrinology and metabolism. () jc20152081. PMID: 26204135 | PMCID: PMC4596045

Hinshaw L, Mallad A, Dalla Man C, Basu R, Cobelli C, Carter RE, Kudva YC, Basu A, Glucagon sensitivity and clearance in type 1 diabetes: insights from in vivo and in silico experiments., 2015; American journal of physiology. Endocrinology and metabolism. 309(5) E474-86. PMID: 26152766 | PMCID: PMC4556882

Visentin R, Dalla Man C, Basu R, Basu A, Rizza RA, Cobelli C, Hepatic insulin sensitivity in healthy and prediabetic subjects: from a dual- to a single-tracer oral minimal model., 2015; American journal of physiology. Endocrinology and metabolism. 309(2) E161-7. PMID: 25991649 | PMCID: PMC4504934

Mallad A, Hinshaw L, Schiavon M, Dalla Man C, Dadlani V, Basu R, Lingineni R, Cobelli C, Johnson ML, Carter R, Kudva YC, Basu A, Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach., 2015; American journal of physiology. Endocrinology and metabolism. 308(12) E1106-15. PMID: 25898950 | PMCID: PMC4469811

Limberg JK, Taylor JL, Mozer MT, Dube S, Basu A, Basu R, Rizza RA, Curry TB, Joyner MJ, Wehrwein EA, Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during hypoglycemia., 2015; Hypertension (Dallas, Tex. : 1979). 65(6) 1365-71. PMID: 25870188 | PMCID: PMC4507506

Huang R, Abdelmoneim SS, Nhola LF, Basu R, Basu A, Mulvagh SL, Relationship between glycosylated hemoglobin A1c and coronary flow reserve in patients with Type 2 diabetes mellitus., 2015; Expert review of cardiovascular therapy. 13(4) 445-53. PMID: 25695762

Dube S, Errazuriz-Cruzat I, Basu A, Basu R, The forgotten role of glucose effectiveness in the regulation of glucose tolerance., 2015; Current diabetes reports. 15(6) 605. PMID: 25869240

Zhang J, Xiang Y, Wang M, Basu A, Lu Y, Dose-Dependent Response of Personal Glucose Meters to Nicotinamide Coenzymes: Applications to Point-of-Care Diagnostics of Many Non-Glucose Targets in a Single Step., 2015; Angewandte Chemie (International ed. in English). 55(2) 732-6. PMID: 26593219 | PMCID: PMC4874735

Wehrwein EA, Limberg JK, Taylor JL, Dube S, Basu A, Basu R, Rizza RA, Curry TB, Joyner MJ, Effect of bilateral carotid body resection on the counterregulatory response to hypoglycaemia in humans., 2015; Experimental physiology. 100(1) 69-78. PMID: 25557731

Schiavon M, Dalla Man C, Dube S, Slama M, Kudva YC, Peyser T, Basu A, Basu R, Cobelli C, Modeling Plasma-to-Interstitium Glucose Kinetics from Multitracer Plasma and Microdialysis Data., 2015; Diabetes technology & therapeutics. 17(11) 825-31. PMID: 26313215 | PMCID: PMC4649763

Dube S, Slama MQ, Basu A, Rizza RA, Basu R, Glucocorticoid Excess Increases Hepatic 11β-HSD-1 Activity in Humans: Implications in Steroid-Induced Diabetes., 2015; The Journal of clinical endocrinology and metabolism. 100(11) 4155-62. PMID: 26308294 | PMCID: PMC4702452

Limberg JK, Dube S, Kuijpers M, Farni KE, Basu A, Rizza RA, Curry TB, Basu R, Joyner MJ, Effect of hypoxia on heart rate variability and baroreflex sensitivity during hypoglycemia in type 1 diabetes mellitus., 2015; Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 25(4) 243-50. PMID: 26141615 | PMCID: PMC4569520

Hinshaw L, Basu A, Technology Use for Problem Solving in Adolescent Type 1 Diabetes., 2015; Diabetes technology & therapeutics. 17(7) 443-4. PMID: 26132765 | PMCID: PMC4504341

Mallad A, Hinshaw L, Dalla Man C, Cobelli C, Basu R, Lingineni R, Carter RE, Kudva YC, Basu A, Nocturnal Glucose Metabolism in Type 1 Diabetes: A Study Comparing Single Versus Dual Tracer Approaches., 2015; Diabetes technology & therapeutics. 17(8) 587-95. PMID: 26121060 | PMCID: PMC4528985

O’Keeffe DT, Maraka S, Basu A, Keith-Hynes P, Kudva YC, Cybersecurity in Artificial Pancreas Experiments., 2015; Diabetes technology & therapeutics. 17(9) 664-6. PMID: 25923544 | PMCID: PMC4556085

Basu A, Basu R, Insulin:Carbohydrate Ratio–Part of the Story., 2015; Diabetes technology & therapeutics. 17(12) 851-3. PMID: 26618719 | PMCID: PMC4677107

Limberg JK, Taylor JL, Dube S, Basu R, Basu A, Joyner MJ, Wehrwein EA, Role of the carotid body chemoreceptors in baroreflex control of blood pressure during hypoglycaemia in humans., 2014; Experimental physiology. 99(4) 640-50. PMID: 24414173 | PMCID: PMC4227537

Basu A, Dube S, Veettil S, Slama M, Kudva YC, Peyser T, Carter RE, Cobelli C, Basu R, Time lag of glucose from intravascular to interstitial compartment in type 1 diabetes., 2014; Journal of diabetes science and technology. 9(1) 63-8. PMID: 25305282 | PMCID: PMC4495531

Limberg JK, Farni KE, Taylor JL, Dube S, Basu A, Basu R, Wehrwein EA, Joyner MJ, Autonomic control during acute hypoglycemia in type 1 diabetes mellitus., 2014; Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 24(6) 275-83. PMID: 25260537

Subaran SC, Sauder MA, Chai W, Jahn LA, Fowler DE, Aylor KW, Basu A, Liu Z, GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans., 2014; Clinical science (London, England : 1979). 127(3) 163-70. PMID: 24552454 | PMCID: PMC4353574

Nandy D, Johnson C, Basu R, Joyner M, Brett J, Svendsen CB, Basu A, The effect of liraglutide on endothelial function in patients with type 2 diabetes., 2014; Diabetes & vascular disease research. 11(6) 419-30. PMID: 25212693

Hinshaw L, Schiavon M, Mallad A, Man CD, Basu R, Bharucha AE, Cobelli C, Carter RE, Basu A, Kudva YC, Effects of delayed gastric emptying on postprandial glucose kinetics, insulin sensitivity, and β-cell function., 2014; American journal of physiology. Endocrinology and metabolism. 307(6) E494-502. PMID: 25074985 | PMCID: PMC4166717

Dube S, Norby B, Pattan V, Lingineni RK, Singh RJ, Carter RE, Basu A, Basu R, Hepatic 11β-hydroxysteroid dehydrogenase type 1 activity in obesity and type 2 diabetes using a novel triple tracer cortisol technique., 2014; Diabetologia. 57(7) 1446-55. PMID: 24771091 | PMCID: PMC5611844

Dube S, Norby BJ, Pattan V, Carter RE, Basu A, Basu R, 11β-hydroxysteroid dehydrogenase types 1 and 2 activity in subcutaneous adipose tissue in humans: implications in obesity and diabetes., 2014; The Journal of clinical endocrinology and metabolism. 100(1) E70-6. PMID: 25303491 | PMCID: PMC4283013

Visentin R, Dalla Man C, Kudva YC, Basu A, Cobelli C, Circadian variability of insulin sensitivity: physiological input for in silico artificial pancreas., 2014; Diabetes technology & therapeutics. 17(1) 1-7. PMID: 25531427 | PMCID: PMC4290795

Bharucha AE, Camilleri M, Burton DD, Thieke SL, Feuerhak KJ, Basu A, Zinsmeister AR, Increased nutrient sensitivity and plasma concentrations of enteral hormones during duodenal nutrient infusion in functional dyspepsia., 2014; The American journal of gastroenterology. 109(12) 1910-20; quiz 1909, 1921. PMID: 25403365 | PMCID: PMC4365900

Lopez-Jimenez F, Simha V, Thomas RJ, Allison TG, Basu A, Fernandes R, Hurst RT, Kopecky SL, Kullo IJ, Mulvagh SL, Thompson WG, Trejo-Gutierrez JF, Wright RS, A summary and critical assessment of the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: filling the gaps., 2014; Mayo Clinic proceedings. 89(9) 1257-78. PMID: 25131697

Bharucha AE, Kudva Y, Basu A, Camilleri M, Low PA, Vella A, Zinsmeister AR, Relationship between glycemic control and gastric emptying in poorly controlled type 2 diabetes., 2014; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 13(3) 466-476.e1. PMID: 25041866 | PMCID: PMC4297596

Basu R, Johnson ML, Kudva YC, Basu A, Exercise, hypoglycemia, and type 1 diabetes., 2014; Diabetes technology & therapeutics. 16(6) 331-7. PMID: 24811269 | PMCID: PMC4029043

Kudva YC, Carter RE, Cobelli C, Basu R, Basu A, Closed-loop artificial pancreas systems: physiological input to enhance next-generation devices., 2014; Diabetes care. 37(5) 1184-90. PMID: 24757225 | PMCID: PMC3994931

Donato LJ, Saenger AK, Train LJ, Kotzer KE, Lagerstedt SA, Hornseth JM, Basu A, Winters JL, Baudhuin LM, Genetic and biochemical analyses in dyslipidemic patients undergoing LDL apheresis., 2014; Journal of clinical apheresis. 29(5) 256-65. PMID: 24420163

Basu A, Dube S, Slama M, Errazuriz I, Amezcua JC, Kudva YC, Peyser T, Carter RE, Cobelli C, Basu R, Time lag of glucose from intravascular to interstitial compartment in humans., 2013; Diabetes. 62(12) 4083-7. PMID: 24009261 | PMCID: PMC3837059

Schiavon M, Hinshaw L, Mallad A, Dalla Man C, Sparacino G, Johnson M, Carter R, Basu R, Kudva Y, Cobelli C, Basu A, Postprandial glucose fluxes and insulin sensitivity during exercise: a study in healthy individuals., 2013; American journal of physiology. Endocrinology and metabolism. 305(4) E557-66. PMID: 23820621 | PMCID: PMC3891224

Hinshaw L, Dalla Man C, Nandy DK, Saad A, Bharucha AE, Levine JA, Rizza RA, Basu R, Carter RE, Cobelli C, Kudva YC, Basu A, Diurnal pattern of insulin action in type 1 diabetes: implications for a closed-loop system., 2013; Diabetes. 62(7) 2223-9. PMID: 23447123 | PMCID: PMC3712033

Schiavon M, Dalla Man C, Kudva YC, Basu A, Cobelli C, In silico optimization of basal insulin infusion rate during exercise: implication for artificial pancreas., 2013; Journal of diabetes science and technology. 7(6) 1461-9. PMID: 24351172 | PMCID: PMC3876324

Schiavon M, Dalla Man C, Kudva YC, Basu A, Cobelli C, Quantitative estimation of insulin sensitivity in type 1 diabetic subjects wearing a sensor-augmented insulin pump., 2013; Diabetes care. 37(5) 1216-23. PMID: 24319120 | PMCID: PMC3994930

Zecchin C, Facchinetti A, Sparacino G, Dalla Man C, Manohar C, Levine JA, Basu A, Kudva YC, Cobelli C, Physical activity measured by physical activity monitoring system correlates with glucose trends reconstructed from continuous glucose monitoring., 2013; Diabetes technology & therapeutics. 15(10) 836-44. PMID: 23944973 | PMCID: PMC3781118

Manohar C, O’Keeffe DT, Hinshaw L, Lingineni R, McCrady-Spitzer SK, Levine JA, Carter RE, Basu A, Kudva YC, Comparison of physical activity sensors and heart rate monitoring for real-time activity detection in type 1 diabetes and control subjects., 2013; Diabetes technology & therapeutics. 15(9) 751-7. PMID: 23937615 | PMCID: PMC3757536

Scalzo P, Basu A, Kudva Y, Current state of diabetes technology clinics and programs in the United States., 2013; Journal of diabetes science and technology. 7(3) 798-9. PMID: 23759414 | PMCID: PMC3869149

Rajpal A, Dube S, Carvalho F, Simoes AR, Figueiredo A, Basu A, Jones J, Basu R, Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes., 2013; American journal of physiology. Endocrinology and metabolism. 305(4) E465-74. PMID: 23736541 | PMCID: PMC3891223

Dube S, Errazuriz I, Cobelli C, Basu R, Basu A, Assessment of insulin action on carbohydrate metabolism: physiological and non-physiological methods., 2013; Diabetic medicine : a journal of the British Diabetic Association. 30(6) 664-70. PMID: 23683103 | PMCID: PMC3662485

Dalla Man C, Piccinini F, Basu R, Basu A, Rizza RA, Cobelli C, Modeling hepatic insulin sensitivity during a meal: validation against the euglycemic hyperinsulinemic clamp., 2013; American journal of physiology. Endocrinology and metabolism. 304(8) E819-25. PMID: 23443923 | PMCID: PMC3625785

Basu A, Kudva YC, Basu R, GPR40 modulators: new kid on the block., 2013; Diabetes care. 36(2) 185-7. PMID: 23349149 | PMCID: PMC3554297

Basu R, Barosa C, Jones J, Dube S, Carter R, Basu A, Rizza RA, Pathogenesis of prediabetes: role of the liver in isolated fasting hyperglycemia and combined fasting and postprandial hyperglycemia., 2013; The Journal of clinical endocrinology and metabolism. 98(3) E409-17. PMID: 23345093 | PMCID: PMC3590488

Parsaik AK, Carter RE, Myers LA, Dong M, Basu A, Kudva YC, Outcomes of community-dwelling adults without diabetes mellitus who require ambulance services for hypoglycemia., 2012; Journal of diabetes science and technology. 6(5) 1107-13. PMID: 23063037 | PMCID: PMC3570845

Pattan V, Parsaik A, Brown JK, Kudva YC, Vlahakis N, Basu A, Glucose control in Mayo Clinic intensive care units., 2012; Journal of diabetes science and technology. 5(6) 1420-6. PMID: 22226259 | PMCID: PMC3262708

Basu A, Pedersen MG, Cobelli C, Prediabetes: evaluation of β-cell function., 2012; Diabetes. 61(2) 270-1. PMID: 22275083 | PMCID: PMC3266404

Dong M, Parsaik AK, Eberhardt NL, Basu A, Cosio FG, Kudva YC, Cellular and physiological mechanisms of new-onset diabetes mellitus after solid organ transplantation., 2012; Diabetic medicine : a journal of the British Diabetic Association. 29(7) e1-12. PMID: 22364599

Parsaik AK, Carter RE, Pattan V, Myers LA, Kumar H, Smith SA, Russi CS, Levine JA, Basu A, Kudva YC, Population-based study of severe hypoglycemia requiring emergency medical service assistance reveals unique findings., 2012; Journal of diabetes science and technology. 6(1) 65-73. PMID: 22401324 | PMCID: PMC3320823

Keenan DM, Basu R, Liu Y, Basu A, Bock G, Veldhuis JD, Logistic model of glucose-regulated C-peptide secretion: hysteresis pathway disruption in impaired fasting glycemia., 2012; American journal of physiology. Endocrinology and metabolism. 303(3) E397-409. PMID: 22669243 | PMCID: PMC3423124

Parsaik AK, Carter RE, Myers LA, Geske JR, Smith SA, Levine JA, Basu A, Kudva YC, Population-based study of hypoglycemia in patients with type 1 diabetes mellitus requiring emergency medical services., 2012; Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 18(6) 834-41. PMID: 22784848

Barosa C, Jones JG, Rizza R, Basu A, Basu R, Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method., 2012; Magnetic resonance in medicine. 70(2) 315-9. PMID: 23023691 | PMCID: PMC3724365

Short KR, Irving BA, Basu A, Johnson CM, Nair KS, Basu R, Effects of type 2 diabetes and insulin on whole-body, splanchnic, and leg protein metabolism., 2012; The Journal of clinical endocrinology and metabolism. 97(12) 4733-41. PMID: 23032060 | PMCID: PMC3591680

Wehrwein EA, Curry TB, Basu A, Rizza RA, Basu R, Joyner MJ, Do the carotid bodies modulate hypoglycemic counterregulation and baroreflex control of blood pressure in humans?, 2012; Advances in experimental medicine and biology. 758() 129-35. PMID: 23080153 | PMCID: PMC3755893

Saad A, Dalla Man C, Nandy DK, Levine JA, Bharucha AE, Rizza RA, Basu R, Carter RE, Cobelli C, Kudva YC, Basu A, Diurnal pattern to insulin secretion and insulin action in healthy individuals., 2012; Diabetes. 61(11) 2691-700. PMID: 22751690 | PMCID: PMC3478548

Manohar C, Levine JA, Nandy DK, Saad A, Dalla Man C, McCrady-Spitzer SK, Basu R, Cobelli C, Carter RE, Basu A, Kudva YC, The effect of walking on postprandial glycemic excursion in patients with type 1 diabetes and healthy people., 2012; Diabetes care. 35(12) 2493-9. PMID: 22875231 | PMCID: PMC3507567

Abdelmoneim SS, Hagen ME, Mendrick E, Pattan V, Wong B, Norby B, Roberson T, Szydel T, Basu R, Basu A, Mulvagh SL, Acute hyperglycemia reduces myocardial blood flow reserve and the magnitude of reduction is associated with insulin resistance: a study in nondiabetic humans using contrast echocardiography., 2012; Heart and vessels. 28(6) 757-68. PMID: 23180239

Parsaik AK, Carter RE, Myers LA, Basu A, Kudva YC, Hypoglycemia requiring ambulance services in patients with type 2 diabetes is associated with increased long-term mortality., 2012; Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 19(1) 29-35. PMID: 23186970

Curry TB, Roberts SK, Basu R, Basu A, Schroeder D, Joyner MJ, Miles JM, Gastric bypass surgery is associated with near-normal insulin suppression of lipolysis in nondiabetic individuals., 2011; American journal of physiology. Endocrinology and metabolism. 300(4) E746-51. PMID: 21304064 | PMCID: PMC3074944

Nandy D, Janardhanan R, Mukhopadhyay D, Basu A, Effect of hyperglycemia on human monocyte activation., 2011; Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 59(4) 661-7. PMID: 21307779 | PMCID: PMC3143266

Abdelmoneim SS, Basu A, Bernier M, Dhoble A, Abdel-Kader SS, Pellikka PA, Mulvagh SL, Detection of myocardial microvascular disease using contrast echocardiography during adenosine stress in type 2 diabetes mellitus: prospective comparison with single-photon emission computed tomography., 2011; Diabetes & vascular disease research. 8(4) 254-61. PMID: 21933841

Basu A, ACP Journal Club. Pioglitazone was associated with lower risk for adverse cardiovascular events than rosiglitazone in older patients., 2010; Annals of internal medicine. 152(4) JC-213. PMID: 20157125

Nandy D, Mukhopadhyay D, Basu A, Both vascular endothelial growth factor and soluble Flt-1 are increased in type 2 diabetes but not in impaired fasting glucose., 2010; Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 58(6) 804-6. PMID: 20571438 | PMCID: PMC3677544

Basu A, Basu R, Pattan V, Rizza RA, Jensen MD, Meal fat storage in subcutaneous adipose tissue: comparison of pioglitazone and glipizide treatment of type 2 diabetes., 2010; Obesity (Silver Spring, Md.). 18(10) 2058-60. PMID: 20539300 | PMCID: PMC3708612

Wehrwein EA, Basu R, Basu A, Curry TB, Rizza RA, Joyner MJ, Hyperoxia blunts counterregulation during hypoglycaemia in humans: possible role for the carotid bodies?, 2010; The Journal of physiology. 588(0) 4593-601. PMID: 20921201 | PMCID: PMC3008860

Basu R, Barosa C, Basu A, Pattan V, Saad A, Jones J, Rizza R, Transaldolase exchange and its effects on measurements of gluconeogenesis in humans., 2010; American journal of physiology. Endocrinology and metabolism. 300(2) E296-303. PMID: 21062960 | PMCID: PMC3043622

Nandy D, Asmann YW, Mukhopadhyay D, Basu A, Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes., 2009; Journal of cellular and molecular medicine. 14(6) 1396-407. PMID: 19754670 | PMCID: PMC2912967

Frye RL, August P, Brooks MM, Hardison RM, Kelsey SF, MacGregor JM, Orchard TJ, Chaitman BR, Genuth SM, Goldberg SH, Hlatky MA, Jones TL, Molitch ME, Nesto RW, Sako EY, Sobel BE, A randomized trial of therapies for type 2 diabetes and coronary artery disease., 2009; The New England journal of medicine. 360(24) 2503-15. PMID: 19502645 | PMCID: PMC2863990

Farkouh ME, Aneja A, Reeder GS, Smars PA, Lennon RJ, Wiste HJ, Traverse K, Razzouk L, Basu A, Holmes DR, Mathew V, Usefulness of diabetes mellitus to predict long-term outcomes in patients with unstable angina pectoris., 2009; The American journal of cardiology. 104(4) 492-7. PMID: 19660600 | PMCID: PMC3755271

Basu R, Chandramouli V, Schumann W, Basu A, Landau BR, Rizza RA, Additional evidence that transaldolase exchange, isotope discrimination during the triose-isomerase reaction, or both occur in humans: effects of type 2 diabetes., 2009; Diabetes. 58(7) 1539-43. PMID: 19366865 | PMCID: PMC2699876

Basu A, Dalla Man C, Basu R, Toffolo G, Cobelli C, Rizza RA, Effects of type 2 diabetes on insulin secretion, insulin action, glucose effectiveness, and postprandial glucose metabolism., 2009; Diabetes care. 32(5) 866-72. PMID: 19196896 | PMCID: PMC2671126

Basu R, Basu A, Grudzien M, Jung P, Jacobson P, Johnson M, Singh R, Sarr M, Rizza RA, Liver is the site of splanchnic cortisol production in obese nondiabetic humans., 2008; Diabetes. 58(1) 39-45. PMID: 18852327 | PMCID: PMC2606891

Pannala R, Basu A, Petersen GM, Chari ST, New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer., 2008; The Lancet. Oncology. 10(1) 88-95. PMID: 19111249 | PMCID: PMC2795483

Vella A, Shah P, Basu A, Rizza RA, Prandial insulin and the systemic appearance of meal-derived glucose in people with type 1 diabetes., 2008; Diabetes care. 31(11) 2230-1. PMID: 18955720 | PMCID: PMC2571049

Sokolnicki LA, Strom NA, Roberts SK, Kingsley-Berg SA, Basu A, Charkoudian N, Skin blood flow and nitric oxide during body heating in type 2 diabetes mellitus., 2008; Journal of applied physiology (Bethesda, Md. : 1985). 106(2) 566-70. PMID: 19056994 | PMCID: PMC2644253

Basu R, Basu A, Chandramouli V, Norby B, Dicke B, Shah P, Cohen O, Landau BR, Rizza RA, Effects of pioglitazone and metformin on NEFA-induced insulin resistance in type 2 diabetes., 2008; Diabetologia. 51(11) 2031-40. PMID: 18769904 | PMCID: PMC2701394

Pannala R, Leirness JB, Bamlet WR, Basu A, Petersen GM, Chari ST, Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus., 2008; Gastroenterology. 134(4) 981-7. PMID: 18395079 | PMCID: PMC2323514

Sheikh-Ali M, Karon BS, Basu A, Kudva YC, Muller LA, Xu J, Schwenk WF, Miles JM, Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis?, 2008; Diabetes care. 31(4) 643-7. PMID: 18184896

Basu A, Charkoudian N, Schrage W, Rizza RA, Basu R, Joyner MJ, Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride., 2007; American journal of physiology. Endocrinology and metabolism. 293(5) E1289-95. PMID: 17711996

Kudva YC, Basu A, Adjunctive inhaled insulin before meals improved glycaemic control more than adjunctive metformin in type 2 diabetes mellitus., 2007; Evidence-based medicine. 11(6) 176. PMID: 17213170

Basu A, Jensen MD, McCann F, Nandy D, Mukhopadhyay D, McConnell JP, Rizza RA, Lack of an effect of pioglitazone or glipizide on lipoprotein-associated phospholipase A2 in type 2 diabetes., 2007; Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 13(2) 147-52. PMID: 17490928

Kudva YC, Basu A, Jenkins GD, Pons GM, Vogelsang DA, Rizza RA, Smith SA, Isley WL, Glycemic variation and hypoglycemia in patients with well-controlled type 1 diabetes on a multiple daily insulin injection program with use of glargine and ultralente as basal insulin., 2007; Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 13(3) 244-50. PMID: 17599855

Gandhi GY, Basu R, Dispenzieri A, Basu A, Montori VM, Brennan MD, Endocrinopathy in POEMS syndrome: the Mayo Clinic experience., 2007; Mayo Clinic proceedings. 82(7) 836-42. PMID: 17605964

Basu R, Shah P, Basu A, Norby B, Dicke B, Chandramouli V, Cohen O, Landau BR, Rizza RA, Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes., 2007; Diabetes. 57(1) 24-31. PMID: 17914032

Basu R, Dalla Man C, Campioni M, Basu A, Nair KS, Jensen MD, Khosla S, Klee G, Toffolo G, Cobelli C, Rizza RA, Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women., 2007; Diabetes. 56(3) 753-66. PMID: 17327446

Basu R, Dalla Man C, Campioni M, Basu A, Nair KS, Jensen MD, Khosla S, Klee G, Toffolo G, Cobelli C, Rizza RA, Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men., 2007; Diabetes care. 30(8) 1972-8. PMID: 17496236

Cohen O, Basu R, Bock G, Dalla Man C, Campioni M, Basu A, Toffolo G, Cobelli C, Rizza RA, Prediction of postprandial glycemic exposure: utility of fasting and 2-h glucose measurements alone and in combination with assessment of body composition, fitness, and strength., 2006; Diabetes care. 29(12) 2708-13. PMID: 17130209

Nair KS, Rizza RA, O’Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ, Smith GE, Khosla S, Jensen MD, DHEA in elderly women and DHEA or testosterone in elderly men., 2006; The New England journal of medicine. 355(16) 1647-59. PMID: 17050889

Basu R, Dalla Man C, Campioni M, Basu A, Klee G, Toffolo G, Cobelli C, Rizza RA, Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction., 2006; Diabetes. 55(7) 2001-14. PMID: 16804069

Kudva YC, Basu A, Adjunctive inhaled insulin before meals improved glycemic control more than adjunctive metformin in type 2 diabetes mellitus., 2006; ACP journal club. 145(3) 67. PMID: 17080979

Basu A, Jensen MD, McCann F, Mukhopadhyay D, Joyner MJ, Rizza RA, Effects of pioglitazone versus glipizide on body fat distribution, body water content, and hemodynamics in type 2 diabetes., 2006; Diabetes care. 29(3) 510-4. PMID: 16505497

Basu R, Singh R, Basu A, Johnson CM, Rizza RA, Effect of nutrient ingestion on total-body and splanchnic cortisol production in humans., 2006; Diabetes. 55(3) 667-74. PMID: 16505229

Sokolnicki LA, Roberts SK, Wilkins BW, Basu A, Charkoudian N, Contribution of nitric oxide to cutaneous microvascular dilation in individuals with type 2 diabetes mellitus., 2006; American journal of physiology. Endocrinology and metabolism. 292(1) E314-8. PMID: 16954331

Zein CO, Levy C, Basu A, Zein NN, Chronic hepatitis C and type II diabetes mellitus: a prospective cross-sectional study., 2005; The American journal of gastroenterology. 100(1) 48-55. PMID: 15654780

Basu R, Singh RJ, Basu A, Chittilapilly EG, Johnson MC, Toffolo G, Cobelli C, Rizza RA, Obesity and type 2 diabetes do not alter splanchnic cortisol production in humans., 2005; The Journal of clinical endocrinology and metabolism. 90(7) 3919-26. PMID: 15811928

Basu A, Service FJ, Yu L, Heser D, Ferries LM, Eisenbarth G, Insulin autoimmunity and hypoglycemia in seven white patients., 2005; Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 11(2) 97-103. PMID: 15901524

Wick DE, Roberts SK, Basu A, Sandroni P, Fealey RD, Sletten D, Charkoudian N, Delayed threshold for active cutaneous vasodilation in patients with Type 2 diabetes mellitus., 2005; Journal of applied physiology (Bethesda, Md. : 1985). 100(2) 637-41. PMID: 16210432

Basu A, Insulin sensitivity: normal and abnormal., 2004; Nestle Nutrition workshop series. Clinical & performance programme. 9() 37-52. PMID: 15361677

Basu R, Basu A, Johnson CM, Schwenk WF, Rizza RA, Insulin dose-response curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetes., 2004; Diabetes. 53(8) 2042-50. PMID: 15277384

Basu R, Singh RJ, Basu A, Chittilapilly EG, Johnson CM, Toffolo G, Cobelli C, Rizza RA, Splanchnic cortisol production occurs in humans: evidence for conversion of cortisone to cortisol via the 11-beta hydroxysteroid dehydrogenase (11beta-hsd) type 1 pathway., 2004; Diabetes. 53(8) 2051-9. PMID: 15277385

Basu A, Shah P, Nielsen M, Basu R, Rizza RA, Effects of type 2 diabetes on the regulation of hepatic glucose metabolism., 2004; Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 52(6) 366-74. PMID: 15612449

Kudva YC, Basu A, Jenkins GD, Pons GM, Quandt LL, Gebel JA, Vogelsang DA, Smith SA, Rizza RA, Isley WL, Randomized controlled clinical trial of glargine versus ultralente insulin in the treatment of type 1 diabetes., 2004; Diabetes care. 28(1) 10-4. PMID: 15616226

Shah P, Basu A, Rizza R, Fat-induced liver insulin resistance., 2003; Current diabetes reports. 3(3) 214-8. PMID: 12762968

Basu R, Breda E, Oberg AL, Powell CC, Dalla Man C, Basu A, Vittone JL, Klee GG, Arora P, Jensen MD, Toffolo G, Cobelli C, Rizza RA, Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance., 2003; Diabetes. 52(7) 1738-48. PMID: 12829641

Zangeneh F, Kudva YC, Basu A, Insulin sensitizers., 2003; Mayo Clinic proceedings. 78(4) 471-9. PMID: 12683699

Vella A, Reed AS, Charkoudian N, Shah P, Basu R, Basu A, Joyner MJ, Rizza RA, Glucose-induced suppression of endogenous glucose production: dynamic response to differing glucose profiles., 2003; American journal of physiology. Endocrinology and metabolism. 285(1) E25-30. PMID: 12637258

Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, Rizza R, Cobelli C, Use of a novel triple-tracer approach to assess postprandial glucose metabolism., 2002; American journal of physiology. Endocrinology and metabolism. 284(1) E55-69. PMID: 12485809

Shah P, Vella A, Basu A, Basu R, Adkins A, Schwenk WF, Johnson CM, Nair KS, Jensen MD, Rizza RA, Elevated free fatty acids impair glucose metabolism in women: decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia., 2002; Diabetes. 52(1) 38-42. PMID: 12502491

Basu A, Sheehan MT, Thompson GB, Service FJ, Insulinoma in chronic renal failure: a case report., 2002; The Journal of clinical endocrinology and metabolism. 87(11) 4889-91. PMID: 12414845

Basu R, Basu A, Nair KS, Muscle changes in aging., 2002; The journal of nutrition, health & aging. 6(5) 336-41. PMID: 12474025

Montori VM, Basu A, Erwin PJ, Velosa JA, Gabriel SE, Kudva YC, Posttransplantation diabetes: a systematic review of the literature., 2002; Diabetes care. 25(3) 583-92. PMID: 11874952

Zangeneh F, Basu A, Type 2 diabetes therapy and liver damage: the debate continues., 2002; Postgraduate medicine. 112(3) 23; author reply 23-4, 82. PMID: 12360654

Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk WF, Rizza RA, Effect of enteral vs. parenteral glucose delivery on initial splanchnic glucose uptake in nondiabetic humans., 2002; American journal of physiology. Endocrinology and metabolism. 283(2) E259-66. PMID: 12110530

Montori VM, Basu A, Kudva YC, Strategies to improve outcomes after renal transplantation., 2002; The New England journal of medicine. 346(26) 2089-92; author reply 2089-92. PMID: 12088020

Shah P, Vella A, Basu A, Basu R, Adkins A, Schwenk WF, Johnson CM, Nair KS, Jensen MD, Rizza RA, Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans., 2002; Diabetes. 51(2) 301-10. PMID: 11812736

Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk FW, Holst JJ, Rizza RA, Effect of glucagon-like peptide-1(7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes., 2001; Diabetes. 50(3) 565-72. PMID: 11246876

Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk WF, Rizza RA, Type I diabetes mellitus does not alter initial splanchnic glucose extraction or hepatic UDP-glucose flux during enteral glucose administration., 2001; Diabetologia. 44(6) 729-37. PMID: 11440366

Basu A, Rizza RA, Glucose effectiveness: measurement in diabetic and nondiabetic humans., 2001; Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 109() S157-65. PMID: 11460567

Basu A, Basu R, Shah P, Vella A, Rizza RA, Jensen MD, Systemic and regional free fatty acid metabolism in type 2 diabetes., 2001; American journal of physiology. Endocrinology and metabolism. 280(6) E1000-6. PMID: 11350782

Basu A, Basu R, Shah P, Vella A, Johnson CM, Jensen M, Nair KS, Schwenk WF, Rizza RA, Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: additional evidence for a defect in hepatic glucokinase activity., 2001; Diabetes. 50(6) 1351-62. PMID: 11375336

Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA, Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus., 2000; The Journal of clinical endocrinology and metabolism. 85(11) 4053-9. PMID: 11095432

Basu A, Basu R, Shah P, Vella A, Johnson CM, Nair KS, Jensen MD, Schwenk WF, Rizza RA, Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity., 2000; Diabetes. 49(2) 272-83. PMID: 10868944

Vella A, Shah P, Basu R, Basu A, Holst JJ, Rizza RA, Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes., 2000; Diabetes. 49(4) 611-7. PMID: 10871199

Shah P, Basu A, Basu R, Rizza R, Impact of lack of suppression of glucagon on glucose tolerance in humans., 1999; The American journal of physiology. 277(2) E283-90. PMID: 10444424

Basu R, Basu A, Nielsen M, Shah P, Rizza RA, Effect of overnight restoration of euglycemia on glucose effectiveness in type 2 diabetes mellitus., 1999; The Journal of clinical endocrinology and metabolism. 84(7) 2314-9. PMID: 10404795

Nielsen MF, Dinneen S, Basu A, Basu R, Alzaid A, Rizza RR, Failure of nocturnal changes in growth hormone to alter carbohydrate tolerance the following morning., 1998; Diabetologia. 41(9) 1064-72. PMID: 9754825

Basu A, Caumo A, Bettini F, Gelisio A, Alzaid A, Cobelli C, Rizza RA, Impaired basal glucose effectiveness in NIDDM: contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol., 1997; Diabetes. 46(3) 421-32. PMID: 9032098

Basu A, Alzaid A, Dinneen S, Caumo A, Cobelli C, Rizza RA, Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance., 1996; The Journal of clinical investigation. 97(10) 2351-61. PMID: 8636416 | PMCID: PMC507316