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Alexandra Kadl

Alexandra Kadl

Associate Professor of Medicine, Medicine- Pulmonary and Critical Care Medicine

Primary Location
P.O. Box 800546
Division of Pulmonary and Critical Care Medicine
Charlottesville, VA 22908
Primary Phone Number
Fax Number
434.924.9682

Bio & Overview

Lung injury and repair, sepsis

Academic Information

Department
Medicine- Pulmonary and Critical Care Medicine
Academic Title
Assistant Professor

Primary Education

  • MD, undefinedMedical University of Vienna, 2003

Other Appointments

  • Postdoctoral Researcher, Pharmacology
  • Assistant Professor, Pharmacology

Other Affiliations

  • Postdoctoral Researcher, Beirne Carter Center for Immunology
  • Faculty, BIMS

Research Interests

Lung injury and repair, sepsis

Research Disciplines

  • Molecular Pharmacology

Research Opportunities

  • Molecular Pharmacology

PhD Programs

  • Pharmacology

Selected Publications

2024

Hendrick, J., Ma, J. Z., Haughey, H. M., Coleman, R., Nayak, U., Kadl, A., . . . Petri, W. A. (2024). Pulmonary Function and Survival 1 Year After Dupilumab Treatment of Acute Moderate to Severe Coronavirus Disease 2019: A Follow-up Study From a Phase 2a Trial. OPEN FORUM INFECTIOUS DISEASES, 11(2). doi:10.1093/ofid/ofad630

2023

Hendrick, J., Ma, J., Haughey, H., Coleman, R., Nayak, U., Kadl, A., . . . Petri, W. (2023). Pulmonary function and survival one year after dupilumab treatment of acute moderate to severe COVID-19: A follow up study from a Phase IIa trial. doi:10.1101/2023.09.01.23293947

Weder, M. M., & Kadl, A. (2023). Longitudinal impact of COVID-19 on lung function in lung transplant recipients: Time to stop worrying?. TRANSPLANT INFECTIOUS DISEASE, 25(5). doi:10.1111/tid.14131

Oliver, S. F., Lazoff, S. A., Popovich, J., Enfield, K. B., Quigg, M., Davis, E. M., & Kadl, A. (2023). Chronic Neurocognitive, Neuropsychological, and Pulmonary Symptoms in Outpatient and Inpatient Cohorts After COVID-19 Infection. NEUROSCIENCE INSIGHTS, 18. doi:10.1177/26331055231186998

2022

Budnick, I. M., Popovich, J. J., Barros, A. J., & Kadl, A. (2022). Change in End-Tidal Co2 After Mini-Fluid Challenge to Determine Fluid Responsiveness. CRITICAL CARE EXPLORATIONS, 4(12). doi:10.1097/CCE.0000000000000816

Brooks, B., Tancredi, C., Song, Y., Mogus, A. T., Huang, M. -L. W., Zhu, H., . . . Zeichner, S. L. (2022). Epstein-Barr Virus and Human Herpesvirus-6 Reactivation in Acute COVID-19 Patients. VIRUSES-BASEL, 14(9). doi:10.3390/v14091872

Konkol, S. B., Ramani, C., Martin, D. N., Harnish-Cruz, C. K., Mietla, K. M., Sessums, R. F., . . . Kadl, A. (2022). Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19. RESPIRATORY MEDICINE, 201. doi:10.1016/j.rmed.2022.106939

Strobel, R. J., Khaja, M. S., Peruri, A., Mullen, M., Kadl, A., Sharma, A., & Teman, N. R. (2022). Veno-Arterial Extracorporeal Membrane Oxygenation and Thrombectomy for Massive Pulmonary Embolism. HEART SURGERY FORUM, 25(2), E241-E242. doi:10.1532/hsf.4435

Taylor, L. J., Jolley, S. E., Ramani, C., Mayer, K. P., Etchill, E. W., Mart, M. F., . . . Rove, J. Y. (2023). Early posthospitalization recovery after extracorporeal membrane oxygenation in survivors of COVID-19. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 166(3). doi:10.1016/j.jtcvs.2021.11.099

Daamen, A. R. R., Bachali, P., Bonham, C. A. A., Somerville, L., Sturek, J. M. M., Grammer, A. C. C., . . . Lipsky, P. E. E. (2022). COVID-19 patients exhibit unique transcriptional signatures indicative of disease severity. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.989556

Keshavarz, B., Richards, N. E., Workman, L. J., Patel, J., Muehling, L. M., Canderan, G., . . . Wilson, J. M. (2022). Trajectory of IgG to SARS-CoV-2 After Vaccination With BNT162b2 or mRNA-1273 in an Employee Cohort and Comparison With Natural Infection. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.850987

2021

Kaso, E. R., Pan, J. A., Salerno, M., Kadl, A., Aldridge, C., Haskal, Z. J., . . . Sharma, A. M. (2022). Venoarterial Extracorporeal Membrane Oxygenation for Acute Massive Pulmonary Embolism: a Meta-Analysis and Call to Action. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 15(2), 258-267. doi:10.1007/s12265-021-10158-0

Ramani, C., & Kadl, A. (2021). Surviving COVID-19 A Burden Yet to Come?. CHEST, 160(1), 15-16. doi:10.1016/j.chest.2021.04.019

Myc, L. A., Richardson, E. D., Barros, A. J., Watson, J. T., Sharma, A. M., & Kadl, A. (2021). Risk Stratification in Acute Pulmonary Embolism: Half of the Way There?. ANNALS OF THE AMERICAN THORACIC SOCIETY, 18(6), 1066-1068. Retrieved from https://www.webofscience.com/

Rowley, D. D., Arrington, S. R., Enfield, K. B., Lamb, K. D., Kadl, A., Davis, J. P., & Theodore, D. J. (2021). Transpulmonary Pressure-Guided Lung-Protective Ventilation Improves Pulmonary Mechanics and Oxygenation Among Obese Subjects on Mechanical Ventilation. RESPIRATORY CARE, 66(7), 1049-1058. doi:10.4187/respcare.08686

Barros, A. J., Enfield, K. B., Kadl, A., & Brady, W. J. (2021). Cardiopulmonary Resuscitation in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest: More Data Are Needed. CRITICAL CARE MEDICINE, 49(8), E793-E794. doi:10.1097/CCM.0000000000004985

Kearns, S. M., Ahern, K. W., Patrie, J. T., Horton, W. B., Harris, T. E., & Kadl, A. (2021). Reduced adiponectin levels in patients with COVID-19 acute respiratory failure: A case-control study. PHYSIOLOGICAL REPORTS, 9(7). doi:10.14814/phy2.14843

Barros, A. J., Enfield, K. B., & Kadl, A. (2021). Intraarterial Catheter Use Is Associated With Increased Risk of Hospital Onset Bacteremia A Retrospective Cohort Study. CHEST, 159(6), 2321-2324. doi:10.1016/j.chest.2021.01.038

Keshavarz, B., Wiencek, J. R., Workman, L. J., Straesser, M. D., Muehling, L. M., Canderan, G., . . . Wilson, J. M. (2021). Quantitative Measurement of IgG to Severe Acute Respiratory Syndrome Coronavirus-2 Proteins Using ImmunoCAP. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 182(5), 417-424. doi:10.1159/000514203

2020

Senthivinayagam, S., Serbulea, V., Upchurch, C. M., Polanowska-Grabowska, R., Mendu, S. K., Sahu, S., . . . Leitinger, N. (2021). Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels. MOLECULAR METABOLISM, 44. doi:10.1016/j.molmet.2020.101130

Keshavarz, B., Wiencek, J., Bazydlo, L., Straesser, M., Workman, L., Platts-Mills, T., & Wilson, J. (2021). Quantitative Measurement of IgG to SARS-CoV-2 Proteins Using the Phadia ImmunoCAP 250. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), AB150. Retrieved from https://www.webofscience.com/

Raje, V., Ahern, K. W., Martinez, B. A., Howell, N. L., Oenarto, V., Granade, M. E., . . . Harris, T. E. (2020). Adipocyte lipolysis drives acute stress-induced insulin resistance. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-75321-0

Ramani, C., Davis, E. M., Kim, J. S., Provencio, J. J., Enfield, K. B., & Kadl, A. (2021). Post-ICU COVID-19 Outcomes A Case Series. CHEST, 159(1), 215-218. doi:10.1016/j.chest.2020.08.2056

Myc, L. A., Solanki, J. N., Barros, A. J., Nuradin, N., Nevulis, M. G., Earasi, K., . . . Kadl, A. (2020). Adoption of a dedicated multidisciplinary team is associated with improved survival in acute pulmonary embolism. RESPIRATORY RESEARCH, 21(1). doi:10.1186/s12931-020-01422-z

2018

Callahan, S. J., Pal, K., Jones, R. M., Davis, E. M., & Kadl, A. (2018). Temperature Control after Cardiac Arrest. When to Start? How Long? How Cold?. American journal of respiratory and critical care medicine, 198(10), 1331-1333. doi:10.1164/rccm.201711-2269rr

2017

Myc, L. A., Stine, J. G., Chakrapani, R., Kadl, A., & Argo, C. K. (2017). Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort. WORLD JOURNAL OF HEPATOLOGY, 9(2), 106-113. doi:10.4254/wjh.v9.i2.106

2016

Bettina, A., Zhang, Z., Michels, K., Cagnina, R. E., Vincent, I. S., Burdick, M. D., . . . Mehrad, B. (2016). M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes. JOURNAL OF IMMUNOLOGY, 196(12), 5047-5055. doi:10.4049/jimmunol.1600306

Adamson, S. E., Griffiths, R., Moravec, R., Senthivinayagam, S., Montgomery, G., Chen, W., . . . Leitinger, N. (2016). Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation. JOURNAL OF CLINICAL INVESTIGATION, 126(4), 1311-1322. doi:10.1172/JCI79590

2012

Juncadella, I. J., Kadl, A., Sharma, A. K., Shim, Y. M., Hochreiter-Hufford, A., Borish, L., & Ravichandran, K. S. (2013). Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. NATURE, 493(7433), 547-+. doi:10.1038/nature11714

2011

Kadl, A., Sharma, P. R., Chen, W., Agrawal, R., Meher, A. K., Rudraiah, S., . . . Leitinger, N. (2011). Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2. FREE RADICAL BIOLOGY AND MEDICINE, 51(10), 1903-1909. doi:10.1016/j.freeradbiomed.2011.08.026

2010

Kadl, A., Meher, A. K., Sharma, P. R., Lee, M. Y., Doran, A. C., Johnstone, S. R., . . . Leitinger, N. (2010). Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2. CIRCULATION RESEARCH, 107(6), 737-U155. doi:10.1161/CIRCRESAHA.109.215715