Mann, Barbara J.

Barbara J. Mann

Barbara J. Mann

Primary Appointment

Associate Professor, Medicine: Infectious Diseases and International Health

Education

  • PhD, Microbiology, University of Virginia

Contact Information

345 Crispell Drive, MR-6 1st floor, Room 1715
Charlottesville, VA 22908
Telephone: 434-924-9666
Fax: 434-924-0075
Email: bjm2r@virginia.edu

Research Interests

Pathogenicity of Francisella tularensis and vaccines

Research Description

Research Interests My research interests focus on the initial interactions between the pathogenic bacteria <i>Francisella tularensis</i> and its host. I am specifically interested in adherence and invasion mechanisms, and protective vaccines. <i>F. tularensis</i> has been designated as a category A select agent for studies in Biodefense Research. <i>Francisella tularensis</i> is a zoonotic infection that can be contracted by several methods including tick bites and inhalation. The low infection dose of 10-50 organisms by an inhalation route led to its development as an agent of biological warfare. The molecular mechanisms of pathogenicity of this gram negative, intracellular bacteria are largely unknown. We are using combined approaches that include bioinformatics, and mutagenesis to identify proteins that mediate adherence to and invasion of host cells. We are also screening for attenuated strains that may be useful as protective vaccines.

Selected Publications