Creutz, Carl E.

Carl E. Creutz

Carl E. Creutz

Primary Appointment

Professor, Pharmacology

Education

  • PhD, John Hopkins University

Contact Information


Telephone: 434-924-5029
Fax: 434-982-3878
Email: cec3n@virginia.edu

Research Interests

Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis

Research Description

Our research group is studying the subcellular mechanisms that underlie the release of hormones and neurotransmitters by exocytosis. In this process a secretory vesicle moves through the cytoplasmic matrix and attaches to the plasma membrane of the cell. Then the membranes of the vesicle and the cell fuse and the contents of the vesicle are released. Subsequently, the vesicle membrane is recovered by endocytosis and degraded or reused to form new secretory vesicles. Our interests have focused on proteins that may regulate or mediate individual steps in this process. In particular, we are studying a novel group of calcium-dependent, membrane-binding proteins that can promote membrane fusion in vitro. This group of proteins, collectively called the annexins, includes synexin, calpactin, lipocortin, and several other members that have been proposed to mediate calcium-dependent events on membrane surfaces. (For a historical review see: http://www.healthsystem.virginia.edu/Internet/researchfaculty/documents/Reflections-on-annexins.pdf ).

Selected Publications