Skip to main content
Elizabeth A. Proctor

Elizabeth A. Proctor

Associate Professor, Neurology

Primary Location
MR-4 Building, Room 3002
Email
[email protected]

Bio & Overview

The Proctor Laboratory integrates systems biology with molecular, cellular, and systems neuroscience into a cutting-edge framework for investigation of multi-scale mechanisms of Alzheimer's disease risk, onset, and progression.

Academic Information

Department
Neurology

Primary Education

  • BS, Physics, Purdue University, 2008
  • BA, Russian Language & Literature, Purdue University, 2008
  • PhD, Bioinformatics & Computational Biology, University of North Carolina at Chapel Hill, 2013
  • Postdoc, Biological Engineering, Massachusetts Institute of Technology, 2018

Other Affiliations

  • MSTP

Research Interests

The Proctor Laboratory integrates systems biology with molecular, cellular, and systems neuroscience into a cutting-edge framework for investigation of multi-scale mechanisms of Alzheimer's disease risk, onset, and progression.

Research Disciplines

  • Alzheimer's Disease
  • Biomedical Engineering
  • Cell and Developmental Biology
  • Computational Biology
  • Data Science in Medicine
  • Development, Stem Cells & Regeneration
  • Experimental Pathology
  • Immunology
  • Metabolism
  • Molecular Biology
  • Molecular and Cellular Physiology
  • Neuroimmunology
  • Neuroscience
  • Physiology
  • Translational Science

Research Opportunities

  • Computational Biology
  • Experimental Pathology
  • Immunology
  • Molecular Biology
  • Neuroscience

PhD Programs

  • Neuroscience

Selected Publications

  1. D. C. Chan, C. Kim, R. Y. Kang, M. K. Kuhn, L. M. Beidler, N. Zhang, E. A. Proctor. “Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer’s disease,” bioRxiv doi:10.1101/2024.03.17.585383 (2024).
  2. M. K. Kuhn and E. A. Proctor. “Microglial drivers of Alzheimer’s disease pathology: an evolution of diverse participating states,” Proteins: Structure, Function, and Bioinformatics, doi:10.1002/prot.26723 (2024).
  3. M. K. Kuhn, R. Y. Kang, C. Kim, Y. Tagay, N. Morris, E. D. Tabdanov, I. A. Elcheva, E. A. Proctor. “Dynamic neuroinflammatory profiles predict Alzheimer’s disease pathology in microglia-containing cerebral organoids,” bioRxiv doi:10.1101/2023.11.16.567220 (2023).
  4. M. K. Kuhn, R. M. Fleeman, L. M. Beidler, A. M. Snyder, D. C. Chan, E. A. Proctor. “Amyloid-β pathology-specific cytokine secretion suppresses neuronal mitochondrial metabolism,” Cellular and Molecular Bioengineering 16:405-421 (2023).
  5. R. M. Fleeman, M. K. Kuhn, D. C. Chan, E. A. Proctor. “Apolipoprotein E4 modulates astrocyte neuronal support functions in the presence of amyloid-β,” Journal of Neurochemistry 165:536-549 (2023).
  6. R. M. Fleeman, A. M. Snyder, M. K. Kuhn, D. C. Chan, G. C. Smith, N. A. Crowley, A. C. Arnold, E. A. Proctor. “Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice,” Neurobiology of Aging 123:154-169 (2023).
  7. R. M. Fleeman and E. A. Proctor. “Astrocytic propagation of tau in the context of Alzheimer’s disease,” Frontiers in Cellular Neuroscience 15:645233 (2021).