Chelsea Marie
Associate Professor, Medicine- Infectious Diseases and International Health
345 Crispell Drive, MR-6, Room 2713
Charlottesville, VA 22908
Bio & Overview
Academic Information
- Department
- Medicine- Infectious Diseases and International Health
- Academic Title
- Assistant Professor
Primary Education
- BS, Microbiology and Chemistry , Oregon State University, 2003
- PhD, Pathobiology , University of Washington, 2008
Research Interests
Research Disciplines
- Immunology
Research Opportunities
- Immunology
Selected Publications
2024
Pierce, R., Jan, N. -J., Kumar, P., Middleton, J., Petri, W. A., & Marie, C. (2024). Persistent dysbiosis of duodenal microbiota in patients with controlled pediatric Crohn's disease after resolution of inflammation. SCIENTIFIC REPORTS, 14(1). doi:10.1038/s41598-024-63299-y
van Voorhis, W., Siwila, J., Kissinger, J. C., Vasquez, N. B., Robinson, G., Baptista, R., . . . Jumani, R. S. (2024). The fi rst Cryptosporidium meeting: a concerted effort to fi ght cryptosporidiosis. TRENDS IN PARASITOLOGY, 40(6), 431-438. doi:10.1016/j.pt.2024.04.005
Fahim, S. M., Donowitz, J. R., Smirnova, E., Jan, N. -J., Das, S., Mahfuz, M., . . . Ahmed, T. (2024). Small Intestine Bacterial Overgrowth is associated with increased Campylobacter and epithelial injury in duodenal biopsies of Bangladeshi children. PLOS NEGLECTED TROPICAL DISEASES, 18(3). doi:10.1371/journal.pntd.0012023
2023
Noor, Z., Hasan, M. M., Gazi, M. A., Hossaini, F., Haque, N. M. S., Palit, P., . . . Ahmed, T. (2023). Immune modulation by nutritional intervention in malnourished children: Identifying the phenotypic distribution and functional responses of peripheral blood mononuclear cells. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 98(3). doi:10.1111/sji.13302
2022
Munday, R. M., Haque, R., Jan, N. -J., Wojcik, G. L., Marie, C., Duchen, D., . . . Duggal, P. (2022). Genome-Wide Association Study of Campylobacter-Positive Diarrhea Identifies Genes Involved in Toxin Processing and Inflammatory Response. MBIO, 13(3). doi:10.1128/mbio.00556-22
O'Brien, M. P., Forleo-Neto, E., Sarkar, N., Isa, F., Hou, P., Chan, K. -C., . . . Weinreich, D. M. (2022). Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 327(5), 432-441. doi:10.1001/jama.2021.24939
McCowin, S., Petri, W. A. J., & Marie, C. (2022). Protein Kinase C-α Is a Gatekeeper of Cryptosporidium Sporozoite Adherence and Invasion. INFECTION AND IMMUNITY, 90(3). doi:10.1128/iai.00679-21
2021
Jan, N., Hays, R. A., Oakland, D. N., Kumar, P., Ramakrishnan, G., Behm, B. W., . . . Marie, C. (2021). Fecal Microbiota Transplantation Increases Colonic IL-25 and Dampens Tissue Inflammation in Patients with Recurrent Clostridioides difficile. MSPHERE, 6(5). doi:10.1128/mSphere.00669-21
McCowin, S., Marie, C., & Petri, W. A. J. (2021). Parasite protein pirates host cytoskeletal modulator during invasion. TRENDS IN PARASITOLOGY, 37(11), 937-939. doi:10.1016/j.pt.2021.09.004
Donlan, A. N., Sutherland, T. E., Marie, C., Preissner, S., Bradley, B. T., Carpenter, R. M., . . . Petri, W. A. J. (2021). IL-13 is a driver of COVID-19 severity. JCI INSIGHT, 6(15). doi:10.1172/jci.insight.150107
O'Brien, M. P., Forleo-Neto, E., Musser, B. J., Isa, F., Chan, K. -C., Sarkar, N., . . . Weinreich, D. M. (2021). Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. NEW ENGLAND JOURNAL OF MEDICINE, 385(13), 1184-1195. doi:10.1056/NEJMoa2109682
McCowin, S. E., Moreau, G. B., Haque, R., Noble, J. A., McDevitt, S. L., Donowitz, J. R., . . . Marie, C. (2021). HLA class I and II associations with common enteric pathogens in the first year of life. EBIOMEDICINE, 67. doi:10.1016/j.ebiom.2021.103346
Donlan, A. N., Sutherland, T. E., Marie, C., Preissner, S., Bradley, B. T., Carpenter, R. M., . . . Petri, W. A. (2021). IL-13 is a driver of COVID-19 severity.. medRxiv. doi:10.1101/2020.06.18.20134353
2020
Billah, S. M., Haque, R., Chowdhury, A. I., Siraj, M. S., Rahman, Q. S., Hossain, T., . . . Petri, W. A. J. (2020). Setting up a maternal and newborn registry applying electronic platform: an experience from the Bangladesh site of the global network for women's and children's health. REPRODUCTIVE HEALTH, 17. doi:10.1186/s12978-020-00993-w
Wojcik, G. L., Korpe, P., Marie, C., Mentzer, A. J., Carstensen, T., Mychaleckyj, J., . . . Duggal, P. (2020). Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA. MBIO, 11(1). doi:10.1128/mBio.03343-19
2019
Wojcik, G., Korpe, P., Marie, C., Kirkpatrick, B. D., Haque, R., Petri, W. A., & Duggal, P. (2019). GENOME-WIDE ASSOCIATION STUDY OF CRYPTOSPORIDIOSIS IN BANGLADESHI INFANTS REVEALS ROLE FOR PKRCA. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 101 (pp. 386-387). Retrieved from https://www.webofscience.com/
2018
Wojcik, G. L., Marie, C., Abhyankar, M. M., Yoshida, N., Watanabe, K., Mentzer, A. J., . . . Duggal, P. (2018). Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease. MBIO, 9(5). doi:10.1128/mBio.01668-18
Marie, C., Ali, A., Chandwe, K., Petri, W. A. J., & Kelly, P. (2018). Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy. MUCOSAL IMMUNOLOGY, 11(5), 1290-1298. doi:10.1038/s41385-018-0036-1
McCowin, S. E., Wojcik, G. L., Duggal, P., Haque, R., Petri, W. A., & Marie, C. (2018). Protein Kinase C activation facilitates Cryptosporidium parvum invasion of intestinal epithelial cells. In MOLECULAR BIOLOGY OF THE CELL Vol. 29. Retrieved from https://www.webofscience.com/
2017
Wojcik, G. L., Marie, C., Mychaleckyj, J. C., Rich, S., Concannon, P., Haque, R., . . . Duggal, P. (2017). GENETIC LINKS BETWEEN SYMPTOMATIC ENTAMOEBA HISTOLYTICA INFECTION AND INFLAMMATORY BOWEL DISEASE. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 95 (pp. 388). Retrieved from https://www.webofscience.com/
2015
Marie, C., Verkerke, H. P., Theodorescu, D., & Petri, W. A. (2015). A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica. SCIENTIFIC REPORTS, 5. doi:10.1038/srep13613
Cowardin, C. A., Kuehne, S. A., Buonomo, E. L., Marie, C. S., Minton, N. P., & Petri, W. A. J. (2015). Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile. MBIO, 6(1). doi:10.1128/mBio.02386-14
Melchor, S. J., Marie, C., & Petri, W. A. J. (2015). USE OF PRIMARY HUMAN INTESTINAL EPITHELIUM CULTURES (ENTEROIDS) TO TEST ROLE OF LEPTIN SIGNALING IN REG1-MEDIATED PROTECTION FROM ENTAMOEBA HISTOLYTICA. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 93 (pp. 346). Retrieved from https://www.webofscience.com/
2014
Verkerke, H., Naylor, C., Zabeau, L., Tavernier, J., Petri, W. A. J., & Marie, C. (2014). Kinetics of Leptin Binding to the Q223R Leptin Receptor. PLOS ONE, 9(4). doi:10.1371/journal.pone.0094843
Marie, C., & Petri, W. A. J. (2014). Regulation of Virulence of Entamoeba histolytica. ANNUAL REVIEW OF MICROBIOLOGY, VOL 68, 68, 493-520. doi:10.1146/annurev-micro-091313-103550
2013
Marie, C., & Petri, W. A. (2013). Amoebic dysentery.. BMJ clinical evidence, 2013, 0918.
2012
Verkerke, H. P., Petri, W. A. J., & Marie, C. S. (2012). The dynamic interdependence of amebiasis, innate immunity, and undernutrition. SEMINARS IN IMMUNOPATHOLOGY, 34(6), 771-785. doi:10.1007/s00281-012-0349-1
Marie, C. S., Verkerke, H. P., Paul, S. N., Mackey, A. J., & Petri, W. A. J. (2012). Leptin Protects Host Cells from Entamoeba histolytica Cytotoxicity by a STAT3-Dependent Mechanism. INFECTION AND IMMUNITY, 80(5), 1934-1943. doi:10.1128/IAI.06140-11
2011
Duggal, P., Guo, X., Haque, R., Peterson, K. M., Ricklefs, S., Mondal, D., . . . Petri, W. A. J. (2011). A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. JOURNAL OF CLINICAL INVESTIGATION, 121(3), 1191-1198. doi:10.1172/JCI45294