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Chelsea Marie

Chelsea Marie

Associate Professor, Medicine- Infectious Diseases and International Health

Primary Location
UVA Division of Infectious Diseases
345 Crispell Drive, MR-6, Room 2713
Charlottesville, VA 22908
Primary Phone Number

Bio & Overview

I am interested in the mucosal immune response to enteric pathogens. My current research includes understanding the cellular and immune mechanisms that underly environmental enteropathy in children in Bangladesh and patients with recurrent Clostridium difficile infection at UVa. My experimental research explores host factors identified in clinical cohorts as potential targets for host-directed therapeutics.

Academic Information

Department
Medicine- Infectious Diseases and International Health
Academic Title
Assistant Professor

Primary Education

  • BS, Microbiology and Chemistry , Oregon State University, 2003
  • PhD, Pathobiology , University of Washington, 2008

Research Interests

Human intestinal parasitology

Research Disciplines

  • Immunology

Research Opportunities

  • Immunology

Selected Publications

2024

Pierce, R., Jan, N. -J., Kumar, P., Middleton, J., Petri, W. A., & Marie, C. (2024). Persistent dysbiosis of duodenal microbiota in patients with controlled pediatric Crohn's disease after resolution of inflammation. SCIENTIFIC REPORTS, 14(1). doi:10.1038/s41598-024-63299-y

van Voorhis, W., Siwila, J., Kissinger, J. C., Vasquez, N. B., Robinson, G., Baptista, R., . . . Jumani, R. S. (2024). The fi rst Cryptosporidium meeting: a concerted effort to fi ght cryptosporidiosis. TRENDS IN PARASITOLOGY, 40(6), 431-438. doi:10.1016/j.pt.2024.04.005

Fahim, S. M., Donowitz, J. R., Smirnova, E., Jan, N. -J., Das, S., Mahfuz, M., . . . Ahmed, T. (2024). Small Intestine Bacterial Overgrowth is associated with increased Campylobacter and epithelial injury in duodenal biopsies of Bangladeshi children. PLOS NEGLECTED TROPICAL DISEASES, 18(3). doi:10.1371/journal.pntd.0012023

2023

Noor, Z., Hasan, M. M., Gazi, M. A., Hossaini, F., Haque, N. M. S., Palit, P., . . . Ahmed, T. (2023). Immune modulation by nutritional intervention in malnourished children: Identifying the phenotypic distribution and functional responses of peripheral blood mononuclear cells. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 98(3). doi:10.1111/sji.13302

2022

Munday, R. M., Haque, R., Jan, N. -J., Wojcik, G. L., Marie, C., Duchen, D., . . . Duggal, P. (2022). Genome-Wide Association Study of Campylobacter-Positive Diarrhea Identifies Genes Involved in Toxin Processing and Inflammatory Response. MBIO, 13(3). doi:10.1128/mbio.00556-22

O'Brien, M. P., Forleo-Neto, E., Sarkar, N., Isa, F., Hou, P., Chan, K. -C., . . . Weinreich, D. M. (2022). Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 327(5), 432-441. doi:10.1001/jama.2021.24939

McCowin, S., Petri, W. A. J., & Marie, C. (2022). Protein Kinase C-α Is a Gatekeeper of Cryptosporidium Sporozoite Adherence and Invasion. INFECTION AND IMMUNITY, 90(3). doi:10.1128/iai.00679-21

2021

Jan, N., Hays, R. A., Oakland, D. N., Kumar, P., Ramakrishnan, G., Behm, B. W., . . . Marie, C. (2021). Fecal Microbiota Transplantation Increases Colonic IL-25 and Dampens Tissue Inflammation in Patients with Recurrent Clostridioides difficile. MSPHERE, 6(5). doi:10.1128/mSphere.00669-21

McCowin, S., Marie, C., & Petri, W. A. J. (2021). Parasite protein pirates host cytoskeletal modulator during invasion. TRENDS IN PARASITOLOGY, 37(11), 937-939. doi:10.1016/j.pt.2021.09.004

Donlan, A. N., Sutherland, T. E., Marie, C., Preissner, S., Bradley, B. T., Carpenter, R. M., . . . Petri, W. A. J. (2021). IL-13 is a driver of COVID-19 severity. JCI INSIGHT, 6(15). doi:10.1172/jci.insight.150107

O'Brien, M. P., Forleo-Neto, E., Musser, B. J., Isa, F., Chan, K. -C., Sarkar, N., . . . Weinreich, D. M. (2021). Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. NEW ENGLAND JOURNAL OF MEDICINE, 385(13), 1184-1195. doi:10.1056/NEJMoa2109682

McCowin, S. E., Moreau, G. B., Haque, R., Noble, J. A., McDevitt, S. L., Donowitz, J. R., . . . Marie, C. (2021). HLA class I and II associations with common enteric pathogens in the first year of life. EBIOMEDICINE, 67. doi:10.1016/j.ebiom.2021.103346

Donlan, A. N., Sutherland, T. E., Marie, C., Preissner, S., Bradley, B. T., Carpenter, R. M., . . . Petri, W. A. (2021). IL-13 is a driver of COVID-19 severity.. medRxiv. doi:10.1101/2020.06.18.20134353

2020

Billah, S. M., Haque, R., Chowdhury, A. I., Siraj, M. S., Rahman, Q. S., Hossain, T., . . . Petri, W. A. J. (2020). Setting up a maternal and newborn registry applying electronic platform: an experience from the Bangladesh site of the global network for women's and children's health. REPRODUCTIVE HEALTH, 17. doi:10.1186/s12978-020-00993-w

Wojcik, G. L., Korpe, P., Marie, C., Mentzer, A. J., Carstensen, T., Mychaleckyj, J., . . . Duggal, P. (2020). Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA. MBIO, 11(1). doi:10.1128/mBio.03343-19

2019

Wojcik, G., Korpe, P., Marie, C., Kirkpatrick, B. D., Haque, R., Petri, W. A., & Duggal, P. (2019). GENOME-WIDE ASSOCIATION STUDY OF CRYPTOSPORIDIOSIS IN BANGLADESHI INFANTS REVEALS ROLE FOR PKRCA. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 101 (pp. 386-387). Retrieved from https://www.webofscience.com/

2018

Wojcik, G. L., Marie, C., Abhyankar, M. M., Yoshida, N., Watanabe, K., Mentzer, A. J., . . . Duggal, P. (2018). Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease. MBIO, 9(5). doi:10.1128/mBio.01668-18

Marie, C., Ali, A., Chandwe, K., Petri, W. A. J., & Kelly, P. (2018). Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy. MUCOSAL IMMUNOLOGY, 11(5), 1290-1298. doi:10.1038/s41385-018-0036-1

McCowin, S. E., Wojcik, G. L., Duggal, P., Haque, R., Petri, W. A., & Marie, C. (2018). Protein Kinase C activation facilitates Cryptosporidium parvum invasion of intestinal epithelial cells. In MOLECULAR BIOLOGY OF THE CELL Vol. 29. Retrieved from https://www.webofscience.com/

2017

Wojcik, G. L., Marie, C., Mychaleckyj, J. C., Rich, S., Concannon, P., Haque, R., . . . Duggal, P. (2017). GENETIC LINKS BETWEEN SYMPTOMATIC ENTAMOEBA HISTOLYTICA INFECTION AND INFLAMMATORY BOWEL DISEASE. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 95 (pp. 388). Retrieved from https://www.webofscience.com/

2015

Marie, C., Verkerke, H. P., Theodorescu, D., & Petri, W. A. (2015). A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica. SCIENTIFIC REPORTS, 5. doi:10.1038/srep13613

Cowardin, C. A., Kuehne, S. A., Buonomo, E. L., Marie, C. S., Minton, N. P., & Petri, W. A. J. (2015). Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile. MBIO, 6(1). doi:10.1128/mBio.02386-14

Melchor, S. J., Marie, C., & Petri, W. A. J. (2015). USE OF PRIMARY HUMAN INTESTINAL EPITHELIUM CULTURES (ENTEROIDS) TO TEST ROLE OF LEPTIN SIGNALING IN REG1-MEDIATED PROTECTION FROM ENTAMOEBA HISTOLYTICA. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 93 (pp. 346). Retrieved from https://www.webofscience.com/

2014

Verkerke, H., Naylor, C., Zabeau, L., Tavernier, J., Petri, W. A. J., & Marie, C. (2014). Kinetics of Leptin Binding to the Q223R Leptin Receptor. PLOS ONE, 9(4). doi:10.1371/journal.pone.0094843

Marie, C., & Petri, W. A. J. (2014). Regulation of Virulence of Entamoeba histolytica. ANNUAL REVIEW OF MICROBIOLOGY, VOL 68, 68, 493-520. doi:10.1146/annurev-micro-091313-103550

2013

Marie, C., & Petri, W. A. (2013). Amoebic dysentery.. BMJ clinical evidence, 2013, 0918.

2012

Verkerke, H. P., Petri, W. A. J., & Marie, C. S. (2012). The dynamic interdependence of amebiasis, innate immunity, and undernutrition. SEMINARS IN IMMUNOPATHOLOGY, 34(6), 771-785. doi:10.1007/s00281-012-0349-1

Marie, C. S., Verkerke, H. P., Paul, S. N., Mackey, A. J., & Petri, W. A. J. (2012). Leptin Protects Host Cells from Entamoeba histolytica Cytotoxicity by a STAT3-Dependent Mechanism. INFECTION AND IMMUNITY, 80(5), 1934-1943. doi:10.1128/IAI.06140-11

2011

Duggal, P., Guo, X., Haque, R., Peterson, K. M., Ricklefs, S., Mondal, D., . . . Petri, W. A. J. (2011). A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. JOURNAL OF CLINICAL INVESTIGATION, 121(3), 1191-1198. doi:10.1172/JCI45294