Daniel Gioeli

Scott, T. G., Sathyan, K. M., Gioeli, D., & Guertin, M. J. (2024). TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha (ER) binding and ER target gene expression in luminal breast cancer cells. PLOS GENETICS, 20(2). doi:10.1371/journal.pgen.1011159

Hasterok, S., Scott, T. G., Roller, D. G., Spencer, A., Dutta, A. B., Sathyan, K. M., . . . Gioeli, D. (2023). The Androgen Receptor Does Not Directly Regulate the Transcription of DNA Damage Response Genes. MOLECULAR CANCER RESEARCH, 21(12), 1329-1341. doi:10.1158/1541-7786.MCR-23-0358

Chow, P. I., Roller, D. G., Boukhechba, M., Shaffer, K. M., Ritterband, L. M., Reilley, M. J., . . . Gioeli, D. G. (2023). Mobile sensing to advance tumor modeling in cancer patients: A conceptual framework. INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH, 34. doi:10.1016/j.invent.2023.100644

Scott, T. G., Sathyan, K. M., Gioeli, D., & Guertin, M. J. (2023). TRPS1 modulates chromatin accessibility to regulate estrogen receptor (ER) binding and ER target gene expression in luminal breast cancer cells.. bioRxiv. doi:10.1101/2023.07.03.547524

Li, J., Huang, T., Hua, J., Wang, Q., Su, Y., Chen, P., . . . He, J. (2023). CD46 targeted ²¹²Pb alpha particle radioimmunotherapy for prostate cancer treatment. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 42(1). doi:10.1186/s13046-023-02636-x

Lehman, C. E., Spencer, A., Hall, S., Shaw, J. J. P., Wulfkuhle, J., Petricoin, E. F., . . . Gioeli, D. (2021). IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-90289-1

Dong, G., Boukhechba, M., Shaffer, K. M., Ritterband, L. M., Gioeli, D. G., Reilley, M. J., . . . Chow, P. I. (2021). Using Graph Representation Learning to Predict Salivary Cortisol Levels in Pancreatic Cancer Patients. JOURNAL OF HEALTHCARE INFORMATICS RESEARCH, 5(4), 401-419. doi:10.1007/s41666-021-00098-4

Ashe, H., Krakowiak, P., Hasterok, S., Sleppy, R., Roller, D. G., & Gioeli, D. (2021). Role of the runt-related transcription factor (RUNX) family in prostate cancer. FEBS JOURNAL, 288(21), 6112-6126. doi:10.1111/febs.15804

Roller, D. G., Hoang, S. A., Rawls, K. D., Owen, K. A., Simmers, M. B., Figler, R. A., . . . Gioeli, D. (2021). Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-84612-z

Roggero, C. M., Jin, L., Cao, S., Sonavane, R., Kopplin, N. G., Ta, H. Q., . . . Dong, Y. (2021). A detailed characterization of stepwise activation of the androgen receptor variant 7 in prostate cancer cells. ONCOGENE, 40(6), 1106-1117. doi:10.1038/s41388-020-01585-5

Wang, S., Li, J., Hua, J., Su, Y., Beckford-Vera, D. R., Zhao, W., . . . He, J. (2021). Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET. CLINICAL CANCER RESEARCH, 27(5), 1305-1315. doi:10.1158/1078-0432.CCR-20-3310

Ta, H. Q., Dworak, N., Ivey, M. L., Roller, D. G., & Gioeli, D. (2020). AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR-CHK2 interaction and prostate cancer survival. ELIFE, 9. doi:10.7554/eLife.51378

Dougherty, M. I., Lehman, C. E., Spencer, A., Mendez, R. E., David, A. P., Taniguchi, L. E., . . . Jameson, M. J. (2020). PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells. MOLECULAR CANCER RESEARCH, 18(9), 1392-1401. doi:10.1158/1541-7786.MCR-19-0592

Lehman, C. E., Khalil, A. A., Axelrod, M. J., Dougherty, M. I., Schoeff, S. S., Taniguchi, L. E., . . . Jameson, M. J. (2020). Antitumor effect of insulin-like growth factor-1 receptor inhibition in head and neck squamous cell carcinoma. LARYNGOSCOPE, 130(6), 1470-1478. doi:10.1002/lary.28236

Ta, H. Q., Whitworth, H., Yin, Y., Conaway, M., Frierson, H. F., Campbell, M. J., . . . Gioeli, D. (2019). Discovery of a novel long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth. MOLECULAR CANCER, 18. doi:10.1186/s12943-019-1039-6

Gioeli, D., Snow, C. J., Simmers, M. B., Hoang, S. A., Figler, R. A., Allende, J. A., . . . Wamhoff, B. R. (2019). Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells. LAB ON A CHIP, 19(7), 1193-1204. doi:10.1039/c8lc00755a

Lehman, C. E., Mendez, R. E., Dougherty, M. I., Allak, A., Adejumo, O. L., Taniguchi, L. E., . . . Jameson, M. J. (2019). Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells. FRONTIERS IN ONCOLOGY, 9. doi:10.3389/fonc.2019.00013

Ta, H. Q., Sleppy, R., Dworak, N., Allend, J. A., & Gioeli, D. (n.d.). Checkpoint kinase 2 and androgen receptor cross-talk regulate the DDR and prostate cancer growth. Endocrine Abstracts. doi:10.1530/endoabs.54.oc7

Danan, D., Lehman, C. E., Mendez, R. E., Langford, B., Koors, P. D., Dougherty, M. I., . . . Jameson, M. J. (2018). Effect of Adipose-Derived Stem Cells on Head and Neck Squamous Cell Carcinoma. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 158(5), 882-888. doi:10.1177/0194599817750361

Olmez, I., Love, S., Xiao, A., Manigat, L., Randolph, P., McKenna, B. D., . . . Purow, B. (2018). Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha. NEURO-ONCOLOGY, 20(2), 192-202. doi:10.1093/neuonc/nox119

Lu, H., Wang, T., Li, J., Fedele, C., Liu, Q., Zhang, J., . . . Languino, L. R. (2016). αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. CANCER RESEARCH, 76(17), 5163-5174. doi:10.1158/0008-5472.CAN-16-0543

Benamar, M., Guessous, F., Du, K., Corbett, P., Obeid, J., Gioeli, D., . . . Abbas, T. (2016). Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. EBIOMEDICINE, 10, 85-100. doi:10.1016/j.ebiom.2016.06.023

Roller, D. G., Capaldo, B., Bekiranov, S., Mackey, A. J., Conaway, M. R., Petricoin, E. F., . . . Weber, M. J. (2016). Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas. ONCOTARGET, 7(3), 2734-2753. doi:10.18632/oncotarget.6548

Zboray, L., Pluciennik, A., Curtis, D., Liu, Y., Berman-Booty, L. D., Orr, C., . . . Merry, D. E. (2015). Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA. CELL REPORTS, 13(10), 2312-2323. doi:10.1016/j.celrep.2015.11.019

Ta, H. Q., Ivey, M. L., Frierson, H. F. J., Conaway, M. R., Dziegielewski, J., Larner, J. M., & Gioeli, D. (2015). Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth. CANCER RESEARCH, 75(23), 5093-5105. doi:10.1158/0008-5472.CAN-15-0224

Axelrod, M. J., Mendez, R. E., Khalil, A., Leimgruber, S. S., Sharlow, E. R., Capaldo, B., . . . Jameson, M. J. (2015). Synergistic apoptosis in head and neck squamous cell carcinoma cells by co-inhibition of insulin-like growth factor-1 receptor signaling and compensatory signaling pathways. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 37(12), 1722-1732. doi:10.1002/hed.23822

Koryakina, Y., Knudsen, K. E., & Gioeli, D. (2015). Cell-cycle-dependent regulation of androgen receptor function. ENDOCRINE-RELATED CANCER, 22(2), 249-264. doi:10.1530/ERC-14-0549

Capaldo, B. J., Roller, D., Axelrod, M. J., Koeppel, A. F., Petricoin, E. F., Slingluff, C. L. J., . . . Bekiranov, S. (2015). Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma. PLOS ONE, 10(9). doi:10.1371/journal.pone.0138210

Ta, H. Q., & Gioeli, D. (2014). The convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancer. ENDOCRINE-RELATED CANCER, 21(5), R395-R407. doi:10.1530/ERC-14-0217

Axelrod, M. J., Gordon, V., Mendez, R. E., Leimgruber, S. S., Conaway, M. R., Sharlow, E. R., . . . Weber, M. J. (2014). p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks. CELLULAR SIGNALLING, 26(8), 1627-1635. doi:10.1016/j.cellsig.2014.03.013

Koryakina, Y., Ta, H. Q., & Gioeli, D. (2014). Androgen receptor phosphorylation: biological context and functional consequences. ENDOCRINE-RELATED CANCER, 21(4), T131-T145. doi:10.1530/ERC-13-0472

Axelrod, M., Gordon, V. L., Conaway, M., Tarcsafalvi, A., Neitzke, D. J., Gioeli, D., & Weber, M. J. (2013). Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms. ONCOTARGET, 4(4), 622-635. doi:10.18632/oncotarget.938

Roller, D. G., Axelrod, M., Capaldo, B. J., Jensen, K., Mackey, A., Weber, M. J., & Gioeli, D. (2012). Synthetic Lethal Screening with Small-Molecule Inhibitors Provides a Pathway to Rational Combination Therapies for Melanoma. MOLECULAR CANCER THERAPEUTICS, 11(11), 2505-2515. doi:10.1158/1535-7163.MCT-12-0461

Whitworth, H., Bhadel, S., Ivey, M., Conaway, M., Spencer, A., Hernan, R., . . . Gioeli, D. (2012). Identification of Kinases Regulating Prostate Cancer Cell Growth Using an RNAi Phenotypic Screen. PLOS ONE, 7(6). doi:10.1371/journal.pone.0038950

Gioeli, D., & Paschal, B. M. (2012). Post-translational modification of the androgen receptor. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 352(1-2), 70-78. doi:10.1016/j.mce.2011.07.004

Gioeli, D., Wunderlich, W., Sebolt-Leopold, J., Bekiranov, S., Wulfkuhle, J. D., Petricoin, E. F. I. I. I., . . . Weber, M. J. (2011). Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer. MOLECULAR CANCER THERAPEUTICS, 10(9), 1581-1590. doi:10.1158/1535-7163.MCT-10-1033

Cinar, B., Collak, F. K., Lopez, D., Akgul, S., Mukhopadhyay, N. K., Kilicarslan, M., . . . Freeman, M. R. (2011). MST1 Is a Multifunctional Caspase-Independent Inhibitor of Androgenic Signaling. CANCER RESEARCH, 71(12), 4303-4313. doi:10.1158/0008-5472.CAN-10-4532

Gordon, V., Bhadel, S., Wunderlich, W., Zhang, J., Ficarro, S. B., Mollah, S. A., . . . Gioeli, D. (2010). CDK9 Regulates AR Promoter Selectivity and Cell Growth through Serine 81 Phosphorylation. MOLECULAR ENDOCRINOLOGY, 24(12), 2267-2280. doi:10.1210/me.2010-0238

Tilghman, R. W., Cowan, C. R., Mih, J. D., Koryakina, Y., Gioeli, D., Slack-Davis, J. K., . . . Parsons, J. T. (2010). Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype. PLOS ONE, 5(9). doi:10.1371/journal.pone.0012905

Kelley, J. B., Talley, A. M., Spencer, A., Gioeli, D., & Paschal, B. M. (2010). Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors. BMC CELL BIOLOGY, 11. doi:10.1186/1471-2121-11-63

Liu, Y., Karaca, M., Zhang, Z., Gioeli, D., Earp, H. S., & Whang, Y. E. (2010). Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases. ONCOGENE, 29(22), 3208-3216. doi:10.1038/onc.2010.103

Gioeli, D. G. (2010). The promise of novel androgen receptor antagonists.. Cell cycle (Georgetown, Tex.), 9(3), 440-441. doi:10.4161/cc.9.3.11045

Ni, L., Yang, C. -S., Gioeli, D., Frierson, H., Toft, D. O., & Paschal, B. M. (2010). FKBP51 Promotes Assembly of the Hsp90 Chaperone Complex and Regulates Androgen Receptor Signaling in Prostate Cancer Cells. MOLECULAR AND CELLULAR BIOLOGY, 30(5), 1243-1253. doi:10.1128/MCB.01891-08