David J. Feith

Casasampere, M., Ung, J., Inanez, A., Dufau, C., Tsuboi, K., Casas, J., . . . Fabrias, G. (2024). A fluorogenic substrate for the detection of lipid amidases in intact cells. JOURNAL OF LIPID RESEARCH, 65(3). doi:10.1016/j.jlr.2024.100520

Assatova, B., Willim, R., Trevisani, C., Haskett, G., Kariya, K. M., Chopra, K., . . . Jain, S. (2024). KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes. CLINICAL CANCER RESEARCH, 30(11), 2514-2530. doi:10.1158/1078-0432.CCR-23-3504

Ung, J., Tan, S. -F., Fox, T. E., Shaw, J. J. P., Taori, M., Horton, B. J., . . . Feith, D. J. (2023). Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia. CANCERS, 15(24). doi:10.3390/cancers15245866

Brammer, J. E., Ballen, K., Sokol, L., Querfeld, C., Nakamura, R., Mishra, A., . . . Loughran, T. (2023). Effective treatment with the selective cytokine inhibitor BNZ-1 reveals the cytokine dependency of T-LGL leukemia. BLOOD, 142(15), 1271-1280. doi:10.1182/blood.2022017643

Fisher-Wellman, K. H., Kassai, M., Hagen, J. T., Neufer, P. D., Kester, M., Loughran Jr., T. P., . . . Cabot, M. C. (2023). Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia. CANCERS, 15(6). doi:10.3390/cancers15061883

Ung, J., Tan, S. -F., Shaw, J., Fox, T., Kester, M., Feith, D., & Loughran, T. J. (2022). Superior Anti-Leukemic Effects of Combined Acid Ceramidase and Bcl-2 Inhibition in Acute Myeloid Leukemia. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 22, S211-S212. Retrieved from https://www.webofscience.com/

Khokhlatchev, A. V., Sharma, A., Deering, T. G., Shaw, J. J. P., Costa-Pinheiro, P., Golla, U., . . . Kester, M. (2022). Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia. FASEB JOURNAL, 36(10). doi:10.1096/fj.202200765R

Cheon, H., Elghawy, O., Shemo, B. C., Feith, D. J., & Loughran, T. P. (2022). LGL leukemia patients exhibit substantial protective humoral responses following SARS-CoV-2 vaccination. EJHAEM, 3(3), 919-923. doi:10.1002/jha2.472

Cheon, H., Xing, J. C., Moosic, K. B., Ung, J., Chan, V. W., Chung, D. S., . . . Loughran Jr, T. P. (2022). Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia. BLOOD, 139(20), 3058-3072. doi:10.1182/blood.2021013164

Baer, C., Kimura, S., Rana, M. S., Kleist, A. B., Flerlage, T., Feith, D. J., . . . Mullighan, C. G. (2022). CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk. NATURE GENETICS, 54(5), 637-+. doi:10.1038/s41588-022-01059-2

Ung, J., Tan, S. -F., Fox, T. E., Shaw, J. J. P., Vass, L. R., Costa-Pinheiro, P., . . . Loughran, T. P. (2022). Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia. BLOOD REVIEWS, 55. doi:10.1016/j.blre.2022.100950

Moosic, K. B., Ananth, K., Andrade, F., Feith, D. J., Darrah, E., & Loughran, T. P. (2022). Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis. FRONTIERS IN ONCOLOGY, 12. doi:10.3389/fonc.2022.869205

Fisher-Wellman, K. H., Hagen, J. T., Kassai, M., Kao, L. -P., Nelson, M. A. M., McLaughlin, K. L., . . . Cabot, M. C. (2022). Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia. FASEB JOURNAL, 36(1). doi:10.1096/fj.202101194RRR

Assmann, J. L. J. C., Leon, L. G., Stavast, C. J., van den Bogaerdt, S. E., Schilperoord-Vermeulen, J., Sandberg, Y., . . . Langerak, A. W. (2022). miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+CD8+T large granular lymphocyte leukemia. LEUKEMIA, 36(4), 983-993. doi:10.1038/s41375-021-01480-2

Olson, T. L., Cheon, H., Xing, J. C., Olson, K. C., Paila, U., Hamele, C. E., . . . Loughran, T. P. J. (2021). Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias. BLOOD, 138(8), 662-673. doi:10.1182/blood.2020005831

Olson, K. C., Moosic, K. B., Jones, M. K., Larkin, P. M. K., Olson, T. L., Toro, M. F., . . . Loughran, T. P. J. (2020). Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations. CANCER MEDICINE, 9(18), 6533-6549. doi:10.1002/cam4.3246

LeBlanc, F. R., Pearson, J. M., Tan, S. -F., Cheon, H., Xing, J. C., Dunton, W., . . . Loughran, T. P. J. (2020). Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1. BRITISH JOURNAL OF HAEMATOLOGY, 190(3), 405-417. doi:10.1111/bjh.16530

Cheon, H., Dziewulska, K. H., Moosic, K. B., Olson, K. C., Gru, A. A., Feith, D. J., & Loughran, T. P. J. (2020). Advances in the Diagnosis and Treatment of Large Granular Lymphocytic Leukemia. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 15(2), 103-112. doi:10.1007/s11899-020-00565-6

Wang, T. T., Yang, J., Dighe, S., Schmachtenberg, M. W., Leigh, N. T., Farber, E., . . . Olson, T. L. (2020). Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation. CANCERS, 12(1). doi:10.3390/cancers12010126

Annageldiyev, C., Tan, S. -F., Thakur, S., Dhanyamraju, P. K., Ramisetti, S. R., Bhadauria, P., . . . Sharma, A. (2020). The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia. FRONTIERS IN ONCOLOGY, 10. doi:10.3389/fonc.2020.00393

Pearson, J. M., Tan, S. -F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., . . . Loughran, T. P. (2020). Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia. MOLECULAR CANCER RESEARCH, 18(3), 352-363. doi:10.1158/1541-7786.MCR-19-0619

Nyland, S. B., Feith, D. J., Poss, M., Olson, T. L., Krissinger, D. J., Poiesz, B. J., . . . Loughran, T. P. (2020). Retroviral sero-reactivity in LGL leukaemia patients and family members. BRITISH JOURNAL OF HAEMATOLOGY, 188(4), 522-527. doi:10.1111/bjh.16223

Barth, B. M., Wang, W., Toran, P. T., Fox, T. E., Annageldiyev, C., Ondrasik, R. M., . . . Claxton, D. F. (2019). Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia. BLOOD ADVANCES, 3(17), 2598-2603. doi:10.1182/bloodadvances.2018021295

Kao, L. -P., Morad, S. A. F., Davis, T. S., MacDougall, M. R., Kassai, M., Abdelmageed, N., . . . Cabot, M. C. (2019). Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. JOURNAL OF LIPID RESEARCH, 60(9), 1590-1602. doi:10.1194/jlr.RA119000251

Li, W., Yang, L., Harris, R. S., Lin, L., Olson, T. L., Hamele, C. E., . . . Poss, M. (2019). Retrovirus insertion site analysis of LGL leukemia patient genomes. BMC MEDICAL GENOMICS, 12. doi:10.1186/s12920-019-0549-9

Moosic, K. B., Paila, U., Olson, K. C., Dziewulska, K., Wang, T. T., Xing, J. C., . . . Olson, T. L. (2019). Genomics of LGL leukemia and select other rare leukemia/lymphomas. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 32(3), 196-206. doi:10.1016/j.beha.2019.06.003

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. -F., Iyer, S., . . . Sharma, A. (2020). The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia. HAEMATOLOGICA, 105(3), 687-696. doi:10.3324/haematol.2018.212886

Morad, S. A. F., MacDougall, M. R., Abdelmageed, N., Kao, L. -P., Feith, D. J., Tan, S. -F., . . . Cabot, M. C. (2019). Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen. EXPERIMENTAL CELL RESEARCH, 381(2), 256-264. doi:10.1016/j.yexcr.2019.05.021

Tan, S. -F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., . . . Loughran, T. P. (2019). Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-B-dependent P-glycoprotein upregulation. JOURNAL OF LIPID RESEARCH, 60(6), 1078-1086. doi:10.1194/jlr.M091876

Olson, K. C., Larkin, P. M. K., Signorelli, R., Hamele, C. E., Olson, T. L., Conaway, M. R., . . . Loughran, T. P. J. (2018). Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes. CYTOKINE, 111, 551-562. doi:10.1016/j.cyto.2018.09.016

Wang, T. T., Yang, J., Zhang, Y., Zhang, M., Dubois, S., Conlon, K. C., . . . Loughran, T. P. J. (2019). IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability. LEUKEMIA, 33(5), 1243-1255. doi:10.1038/s41375-018-0290-y

Yang, J., LeBlanc, F. R., Dighe, S. A., Hamele, C. E., Olson, T. L., Feith, D. J., & Loughran, T. P. J. (2018). TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia. BLOOD, 131(25), 2803-2815. doi:10.1182/blood-2017-09-808816

Kulling, P. M., Olson, K. C., Hamele, C. E., Toro, M. F., Tan, S. -F., Feith, D. J., & Loughran, T. P. J. (2018). Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLOS ONE, 13(2). doi:10.1371/journal.pone.0193429

Kulling, P. M., Olson, K. C., Olson, T. L., Hamele, C. E., Carter, K. N., Feith, D. J., & Loughran, T. P. J. (2018). Calcitriol-mediated reduction in IFN-γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 177, 140-148. doi:10.1016/j.jsbmb.2017.07.009

Tan, S. -F., Pearson, J. M., Feith, D. J., & Loughran, T. P. J. (2017). The emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia. EXPERT OPINION ON THERAPEUTIC TARGETS, 21(6), 583-590. doi:10.1080/14728222.2017.1322065

Morad, S. A. F., Davis, T. S., MacDougall, M. R., Tan, S. -F., Feith, D. J., Desai, D. H., . . . Cabot, M. G. (2017). Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer. BIOCHEMICAL PHARMACOLOGY, 130, 21-33. doi:10.1016/j.bcp.2017.02.002

Kulling, P. M., Olson, K. C., Olson, T. L., Feith, D. J., & Loughran, T. P. J. (2017). Vitamin D in hematological disorders and malignancies. EUROPEAN JOURNAL OF HAEMATOLOGY, 98(3), 187-197. doi:10.1111/ejh.12818

Tan, S. -F., Liu, X., Fox, T. E., Barth, B. M., Sharma, A., Turner, S. D., . . . Loughran, T. P. J. (2016). Acid ceramidase is upregulated in AML and represents a novel therapeutic target. ONCOTARGET, 7(50), 83208-83222. doi:10.18632/oncotarget.13079

Olson, K. C., Kulling, P. M., Olson, T. L., Tan, S. -F., Rainbow, R. J., Feith, D. J., & Loughran, T. P. J. (2017). Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL leukemia. CANCER BIOLOGY & THERAPY, 18(5), 290-303. doi:10.1080/15384047.2016.1235669

Keller, R. R., Gestl, S. A., Lu, A. Q., Hoke, A., Feith, D. J., & Gunther, E. J. (2016). Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias. CARCINOGENESIS, 37(8), 810-816. doi:10.1093/carcin/bgw061

Morad, S. A. F., Ryan, T. E., Neufer, P. D., Zeczycki, T. N., Davis, T. S., MacDougall, M. R., . . . Cabot, M. C. (2016). Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. JOURNAL OF LIPID RESEARCH, 57(7), 1231-1242. doi:10.1194/jlr.M067389

Gazitt, T., Lood, C., Sun, X., Feith, D., Ledbetter, J., Starkebaum, G., . . . Elkon, K. B. (2016). Cell-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?. ARTHRITIS & RHEUMATOLOGY, 68. Retrieved from https://www.webofscience.com/

Morad, S. A. F., Tan, S. -F., Feith, D. J., Kester, M., Claxton, D. F., Loughran, T. P. J., . . . Cabot, M. C. (2015). Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia-Impact on enzyme activity and response to cytotoxics. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1851(7), 919-928. doi:10.1016/j.bbalip.2015.03.001

Steinway, S. N., Zanudo, J. G. T., Michel, P. J., Feith, D. J., Loughran, T. P., & Albert, R. (2015). Combinatorial interventions inhibit TGFβ-driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypes. NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 1. doi:10.1038/npjsba.2015.14

LeBlanc, F. R., Liu, X., Hengst, J., Fox, T., Calvert, V., Petricoin, E. F. I. I. I., . . . Loughran, T. P. J. (2015). Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. CANCER BIOLOGY & THERAPY, 16(12), 1830-1840. doi:10.1080/15384047.2015.1078949

Nowotarski, S. L., Feith, D. J., & Shantz, L. M. (2015). Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines. CANCER GROWTH AND METASTASIS, 17-27. doi:10.4137/CGM.S21219

Yan, Y., Olson, T. L., Nyland, S. B., Feith, D. J., & Loughran, T. P. (2015). Emergence of a STAT3 mutated NK clone in LGL leukemia.. Leukemia research reports, 4(1), 4-7. doi:10.1016/j.lrr.2014.12.001

Hasanali, Z. S., Epner, E. M., Feith, D. J., Loughran, T. P. J., & Sample, C. E. (2014). Vorinostat Downregulates CD30 and Decreases Brentuximab Vedotin Efficacy in Human Lymphocytes. MOLECULAR CANCER THERAPEUTICS, 13(12), 2784-2792. doi:10.1158/1535-7163.MCT-14-0593

Sun, X., Hasanali, Z. S., Chen, A., Zhang, D., Liu, X., Wang, H. -G., . . . Xu, K. (2015). Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia. BRITISH JOURNAL OF HAEMATOLOGY, 168(3), 371-383. doi:10.1111/bjh.13143

Steinway, S. N., Zanudo, J. G. T., Ding, W., Rountree, C. B., Feith, D. J., Loughran, T. P. J., & Albert, R. (2014). Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation. CANCER RESEARCH, 74(21), 5963-5977. doi:10.1158/0008-5472.CAN-14-0225

Lange, I., Geerts, D., Feith, D. J., Mocz, G., Koster, J., & Bachmann, A. S. (2014). Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell Proliferation. JOURNAL OF MOLECULAR BIOLOGY, 426(2), 332-346. doi:10.1016/j.jmb.2013.09.037

Morad, S. A. F., Levin, J. C., Tan, S. -F., Fox, T. E., Feith, D. B., & Cabot, M. C. (2013). Novel off-target effect of tamoxifen - Inhibition of acid ceramidase activity in cancer cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1831(12), 1657-1664. doi:10.1016/j.bbalip.2013.07.016

Koomoa, D. -L. T., Geerts, D., Lange, I., Koster, J., Pegg, A. E., Feith, D. J., & Bachmann, A. S. (2013). DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27^Kip1 activity in neuroblastoma. INTERNATIONAL JOURNAL OF ONCOLOGY, 42(4), 1219-1228. doi:10.3892/ijo.2013.1835

Brown, T. J., Garcia, A. M., Tan, S. -F., Kissinger, L. N., Feith, D. J., Barth, B. M., & Claxton, D. F. (2013). Improving the anti-AML efficacy of liposomal ceramide by targeting sphingolipid metabolism. CANCER RESEARCH, 73(8). doi:10.1158/1538-7445.AM2013-3396

Ryland, L. K., Doshi, U. A., Shanmugavelandy, S. S., Fox, T. E., Aliaga, C., Broeg, K., . . . Kester, M. (2013). C6-Ceramide Nanoliposomes Target the Warburg Effect in Chronic Lymphocytic Leukemia. PLOS ONE, 8(12). doi:10.1371/journal.pone.0084648

Feith, D. J., Pegg, A. E., & Fong, L. Y. Y. (2013). Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. CARCINOGENESIS, 34(3), 570-576. doi:10.1093/carcin/bgs377

Shi, C., Cooper, T. K., McCloskey, D. E., Glick, A. B., Shantz, L. M., & Feith, D. J. (2012). S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. CARCINOGENESIS, 33(7), 1310-1318. doi:10.1093/carcin/bgs184

Welsh, P. A., Sass-Kuhn, S., Prakashagowda, C., McCloskey, D., & Feith, D. (2012). Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.. Cancer biology & therapy, 13(6), 358-368. doi:10.4161/cbt.19241

Welsh, P. A., Sass-Kuhn, S., Prakashagowda, C., McCloskey, D. E., & Feith, D. J. (2012). Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis. CANCER BIOLOGY & THERAPY, 13(6), 358-368. doi:10.4161/cbt.19241

Shi, C., Welsh, P. A., Sass-Kuhn, S., Wang, X., McCloskey, D. E., Pegg, A. E., & Feith, D. J. (2012). Characterization of transgenic mice with overexpression of spermidine synthase. AMINO ACIDS, 42(2-3), 495-505. doi:10.1007/s00726-011-1028-6

Feith, D. J. (2011). Carcinogenesis Studies in Mice with Genetically Engineered Alterations in Polyamine Metabolism. POLYAMINES: METHODS AND PROTOCOLS, 720, 129-141. doi:10.1007/978-1-61779-034-8_7

Geerts, D., Koster, J., Albert, D., Koomoa, D. -L. T., Feith, D. J., Pegg, A. E., . . . Bachmann, A. S. (2010). The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. INTERNATIONAL JOURNAL OF CANCER, 126(9), 2012-2024. doi:10.1002/ijc.25074

Feith, D. (2010). Tamil and Sinhala relations in Sri Lanka: a historical and contemporary perspective. GLOBAL CHANGE PEACE & SECURITY, 22(3), 345-353. doi:10.1080/14781158.2010.510270