Daniel M. Keenan

Keenan, D. M., Hefti, J. P., Veldhuis, J. D., & Von Wolff, M. (2020). Regulation and adaptation of endocrine axes at high altitude. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 318(2), E297-E309. doi:10.1152/ajpendo.00243.2019

Keenan, D. M., Veldhuis, J. D., Basu, A., & Basu, R. (2019). A novel measure of glucose homeostasis (or loss thereof) comprising the joint dynamics of glucose, insulin, glucagon, and cortisol. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 316(6), E998-E1011. doi:10.1152/ajpendo.00078.2018

Kiran, M., Chatrath, A., Tang, X., Keenan, D. M., & Dutta, A. (2019). A Prognostic Signature for Lower Grade Gliomas Based on Expression of Long Non-Coding RNAs. MOLECULAR NEUROBIOLOGY, 56(7), 4786-4798. doi:10.1007/s12035-018-1416-y

Keenan, D. M., & Veldhuis, J. D. (2016). Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in Quantification. PHYSIOLOGY, 31(1), 34-50. doi:10.1152/physiol.00027.2015

Keenan, D. M., Quinkert, A. W., & Pfaff, D. W. (2015). Stochastic Modeling of Mouse Motor Activity under Deep Brain Stimulation: The Extraction of Arousal Information. PLOS COMPUTATIONAL BIOLOGY, 11(2). doi:10.1371/journal.pcbi.1003883

Hoyos, C. M., Killick, R., Keenan, D. M., Baxter, R. C., Veldhuis, J. D., & Liu, P. Y. (2014). Continuous Positive Airway Pressure Increases Pulsatile Growth Hormone Secretion and Circulating Insulin-like Growth Factor-1 in a Time-Dependent Manner in Men With Obstructive Sleep Apnea: A Randomized Sham-Controlled Study. SLEEP, 37(4), 733-741. doi:10.5665/sleep.3580

Roelfsema, F., Pijl, H., Keenan, D. M., & Veldhuis, J. D. (2012). Diminished adrenal sensitivity and ACTH efficacy in obese premenopausal women. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 167(5), 633-642. doi:10.1530/EJE-12-0592

Veldhuis, J. D., Liu, P. Y., Takahashi, P. Y., & Keenan, D. M. (2012). Dynamic testosterone responses to near-physiological LH pulses are determined by the time pattern of prior intravenous LH infusion. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 303(6), E720-E728. doi:10.1152/ajpendo.00200.2012

Keenan, D. M., Wang, X., Pincus, S. M., & Veldhuis, J. D. (2012). Modelling the nonlinear time dynamics of multidimensional hormonal systems. JOURNAL OF TIME SERIES ANALYSIS, 33(5), 779-796. doi:10.1111/j.1467-9892.2012.00795.x

Keenan, D. M., Basu, R., Liu, Y., Basu, A., Bock, G., & Veldhuis, J. D. (2012). Logistic model of glucose-regulated C-peptide secretion: hysteresis pathway disruption in impaired fasting glycemia. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 303(3), E397-E409. doi:10.1152/ajpendo.00494.2011

Roelfsema, F., Pijl, H., Keenan, D. M., & Veldhuis, J. D. (2012). Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index. PLOS ONE, 7(2). doi:10.1371/journal.pone.0031305

Carroll, B. J., Iranmanesh, A., Keenan, D. M., Cassidy, F., Wilson, W. H., & Veldhuis, J. D. (2012). Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback. ACTA PSYCHIATRICA SCANDINAVICA, 125(6), 478-491. doi:10.1111/j.1600-0447.2011.01821.x

Keenan, D. M., Clarke, I. J., & Veldhuis, J. D. (2011). Noninvasive Analytical Estimation of Endogenous GnRH Drive: Analysis Using Graded Competitive GnRH-Receptor Antagonism and a Calibrating Pulse of Exogenous GnRH. ENDOCRINOLOGY, 152(12), 4882-4893. doi:10.1210/en.2011-1461

Veldhuis, J. D., Liu, P. Y., Keenan, D. M., & Takahashi, P. Y. (2012). Older men exhibit reduced efficacy of and heightened potency downregulation by intravenous pulses of recombinant human LH: a study in 92 healthy men. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302(1), E117-E122. doi:10.1152/ajpendo.00450.2011

Iranmanesh, A., Keenan, D. M., Aoun, P., & Veldhuis, J. D. (2011). Overnight ACTH-cortisol dose responsiveness: comparison with 24-h data, metyrapone administration and insulin-tolerance test in healthy adults. CLINICAL ENDOCRINOLOGY, 75(5), 596-601. doi:10.1111/j.1365-2265.2011.04125.x

Roelfsema, F., Keenan, D. M., & Veldhuis, J. D. (2011). Endogenous ACTH Concentration-Cortisol Secretion Dose Analysis Unmasks Decreased ACTH Potency in Cushing's Disease with Restoration after Successful Pituitary Adenomectomy. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 96(12), 3768-3774. doi:10.1210/jc.2011-1878

Wang, X., Keenan, D. M., Pincus, S. M., Liu, P. Y., & Veldhuis, J. D. (2011). Oscillations in joint synchrony of reproductive hormones in healthy men. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 301(6), E1163-E1173. doi:10.1152/ajpendo.00138.2011

Veldhuis, J. D., Iranmanesh, A., Roelfsema, F., Aoun, P., Takahashi, P., Miles, J. M., & Keenan, D. M. (2011). Tripartite Control of Dynamic ACTH-Cortisol Dose Responsiveness by Age, Body Mass Index, and Gender in 111 Healthy Adults. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 96(9), 2874-2881. doi:10.1210/jc.2011-0084

Keenan, D. M., Iranmanesh, A., & Veldhuis, J. D. (2011). Analytical construct of reversible desensitization of pituitary-testicular signaling: illustrative application in aging. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 300(2), R349-R360. doi:10.1152/ajpregu.00477.2010

Veldhuis, J. D., Roelfsema, F., Keenan, D. M., & Pincus, S. (2011). Gender, Age, Body Mass Index, and IGF-I Individually and Jointly Determine Distinct GH Dynamics: Analyses in One Hundred Healthy Adults. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 96(1), 115-121. doi:10.1210/jc.2010-1669

Veldhuis, J. D., Takahashi, P. Y., Keenan, D. M., Liu, P. Y., Mielke, K. L., & Weist, S. M. (2010). Age disrupts androgen receptor-modulated negative feedback in the gonadal axis in healthy men. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 299(4), E675-E682. doi:10.1152/ajpendo.00300.2010

Keenan, D. M., Roelfsema, F., & Veldhuis, J. D. (2010). Dose-response downregulation within the span of single interpulse intervals. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 299(1), R11-R18. doi:10.1152/ajpregu.00201.2010

Meyfroidt, G., Keenan, D. M., Wang, X., Wouters, P. J., Veldhuis, J. D., & Van den Berghe, G. (2010). Dynamic characteristics of blood glucose time series during the course of critical illness: Effects of intensive insulin therapy and relative association with mortality. CRITICAL CARE MEDICINE, 38(4), 1021-1029. doi:10.1097/CCM.0b013e3181cf710e

Veldhuis, J. D., Keenan, D. M., Liu, P. Y., & Takahashi, P. Y. (2010). Kinetics of removal of intravenous testosterone pulses in normal men. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 162(4), 787-794. doi:10.1530/EJE-09-1085