David Schiff
Professor, Neurology
Bio & Overview
Academic Information
- Department
- Neurology
- Academic Title
- Professor
Primary Education
- AB, General Studies, Harvard University, Cambridge, MA, 1981
- MD, Medicine, Harvard Medicine School, Boston, MA, 1988
- Intern, Internal Medicine, Brigham & Women’s Hospital, Harvard Medical School, 1989
- Resident, Neurology, Harvard Longwood Neurology, Boston, MA, 1992
- Fellowship, Neuro-oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 1993
- Fellowship, Neuro-oncology, Mayo Clinic, Rochester, MN, 1994
Other Affiliations
- Member, Molecular Genetics and Epigenetics Program
Research Interests
Selected Publications
Schiff D, Sheehan JP, SBRT and spinal metastasis: finding its niche., 2012; The lancet oncology. 13(4) 328-9. PMID: 22285200
Nicolasjilwan M, Lopes MB, Larner J, Wintermark M, Schiff D, Subependymal seeding of low-grade oligodendroglial neoplasms: a case series., 2012; Journal of neuro-oncology. 108(1) 99-108. PMID: 22311105
Ribas ES, Schiff D, Spinal cord compression., 2012; Current treatment options in neurology. 14(4) 391-401. PMID: 22547256
Jo J, Schiff D, Purow B, Angiogenic inhibition in high-grade gliomas: past, present and future., 2012; Expert review of neurotherapeutics. 12(6) 733-47. PMID: 22650175
Aregawi DG, Sherman JH, Schiff D, Neurological complications of solid tumors., 2012; Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn. 105() 683-710. PMID: 22230528
Schiff D, Lam EM, Parisi JE, Giannini C, Uhm JH, Keegan BM, Kantarci OH, A 21-year-old woman with multiple cancers and a new brain lesion., 2012; Neurology. 78(10) 743-9. PMID: 22391604
Sherman JH, Moldovan K, Yeoh HK, Starke RM, Pouratian N, Shaffrey ME, Schiff D, Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomas., 2011; Journal of neurosurgery. 114(6) 1617-21. PMID: 21235313
Guessous F, Yang Y, Johnson E, Marcinkiewicz L, Smith M, Zhang Y, Kofman A, Schiff D, Christensen J, Abounader R, Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy., 2011; Molecular cancer therapeutics. 11(2) 288-97. PMID: 22188814 | PMCID: PMC3277676
Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, Kotelevskaya E, Brown J, Schiff D, Abounader R, The roles of viruses in brain tumor initiation and oncomodulation., 2011; Journal of neuro-oncology. 105(3) 451-66. PMID: 21720806 | PMCID: PMC3278219
Schiff D, Jensen ME, Kyphoplasty in cancer: an encouraging step., 2011; The lancet oncology. 12(3) 202-3. PMID: 21333598
Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, Kotelevskaya E, Brown J, Schiff D, Abounader R, The roles of viruses in brain tumor initiation and oncomodulation., 2011; J Neurooncol. 0(0) null. PMID:
Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, Kotelevskaya E, Brown J, Schiff D, Abounader R, The roles of viruses in brain tumor initiation and oncomodulation., 2011; J Neurooncol. 0(0) null. PMID:
Schiff D, Editorial., 2011; J Neurosurg. 0(0) null. PMID:
Bourne TD, Schiff D, Update on molecular findings, management and outcome in low-grade gliomas., 2010; Nat Rev Neurol. 0(0) null. PMID:
Bush ZM, Longtine JA, Cunningham T, Schiff D, Jane Jr, Vance ML, Thorner MO, Laws Jr, Lopes MB, Temozolomide treatment for aggressive pituitary tumors: correlation of clinical outcome with O(6)-methylguanine methyltransferase (MGMT) promoter methylation and expression., 2010; J Clin Endocrinol Metab. 95(11) E280-90. PMID:
Sherman JH, Prevedello DM, Shah L, Raghavan P, Pouratian N, Starke RM, Lopes MB, Shaffrey ME, Schiff D, MR imaging characteristics of oligodendroglial tumors with assessment of 1p/19q deletion status., 2010; Acta Neurochir (Wien). 152(11) 1827-34. PMID:
Taylor JW, Schiff D, Metastatic epidural spinal cord compression., 2010; Semin Neurol. 30(3) 245-53. PMID:
Guessous F, Zhang Y, Kofman A, Catania A, Li Y, Schiff D, Purow B, Abounader R, microRNA-34a is tumor suppressive in brain tumors and glioma stem cells., 2010; Cell Cycle. 9(6) null. PMID:
Louis RG, Schiff D, Shaffrey ME, The first reported localisation and resection of a brain tumour., 2010; Lancet Oncol. 11(3) 302.0. PMID:
Cavaliere R, Petroni G, Lopes MB, Schiff D, Primary central nervous system post-transplantation lymphoproliferative disorder: an International Primary Central Nervous System Lymphoma Collaborative Group Report., 2010; Cancer. 116(4) 863-70. PMID:
Zhang Y, Guessous F, Kofman A, Schiff D, Abounader R, XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC., 2010; IDrugs. 13(2) 112-21. PMID:
Purow BW, Schiff D, Glioblastoma genetics: in rapid flux., 2010; Discov Med. 9(45) 125-31. PMID:
Guessous F, Zhang Y, diPierro C, Marcinkiewicz L, Sarkaria J, Schiff D, Buchanan S, Abounader R, An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth., 2010; Anticancer Agents Med Chem. 10(1) 28-35. PMID:
Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, Johnson E, Marcinkiewicz L, Jiang J, Yang Y, Schmittgen TD, Lopes B, Schiff D, Purow B, Abounader R, MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes., 2009; Cancer Res. 69(19) 7569-76. PMID: | PMCID: PMC2756313
Sherman JH, Aregawi DG, Lai A, Fathallah-Shaykh HM, Bierman PJ, Linsky K, Larner JM, Newman SA, Schiff D, Optic neuropathy in patients with glioblastoma receiving bevacizumab., 2009; Neurology. 73(22) 1924-6. PMID: | PMCID: PMC2796439
Schiff D, Wen PY, van MJ, Neurological adverse effects caused by cytotoxic and targeted therapies., 2009; Nat Rev Clin Oncol. 6(10) 596-603. PMID:
Aregawi D, Lopez D, Wick M, Scheld WM, Schiff D, Disseminated strongyloidiasis complicating glioblastoma therapy: a case report., 2009; J Neurooncol. 94(3) 439-43. PMID:
Schiff D, Purow BW, Neuro-oncology: Isocitrate dehydrogenase mutations in low-grade gliomas., 2009; Nat Rev Neurol. 5(6) 303-4. PMID:
Mandell JW, Glass G, Gianchandani EP, Locke CN, Amos S, Bourne TD, Schiff D, Papin JA, Dephosphorylation of beta-arrestin 1 in glioblastomas., 2009; J Neuropathol Exp Neurol. 68(5) 535-41. PMID:
Li Y, Guessous F, DiPierro C, Zhang Y, Mudrick T, Fuller L, Johnson E, Marcinkiewicz L, Engelhardt M, Kefas B, Schiff D, Kim J, Abounader R, Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy., 2009; Mol Cancer Ther. 8(2) 376-85. PMID:
Purow B, Schiff D, Advances in the genetics of glioblastoma: are we reaching critical mass?, 2009; Nat Rev Neurol. 5(8) 419-26. PMID:
Pouratian N, Mut M, Jagannathan J, Lopes MB, Shaffrey ME, Schiff D, Low-grade gliomas in older patients: a retrospective analysis of prognostic factors., 2008; J Neurooncol. 90(3) 341-50. PMID:
Aregawi DG, Sherman JH, Douvas MG, Burns TM, Schiff D, Neuroleukemiosis: case report of leukemic nerve infiltration in acute lymphoblastic leukemia., 2008; Muscle Nerve. 38(3) 1196-200. PMID:
Schiff D, Purow B, Bevacizumab in combination with irinotecan for patients with recurrent glioblastoma multiforme., 2008; Nat Clin Pract Oncol. 5(4) 186-7. PMID:
Li Y, Guessous F, Kwon S, Kumar M, Ibidapo O, Fuller L, Johnson E, Lal B, Hussaini I, Bao Y, Laterra J, Schiff D, Abounader R, PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations., 2008; Cancer Res. 68(6) 1723-31. PMID: | PMCID: NIHMS135586
Li Y, Guessous F, Johnson EB, Eberhart CG, Li XN, Shu Q, Fan S, Lal B, Laterra J, Schiff D, Abounader R, Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma., 2008; Lab Invest. 88(2) 98-111. PMID:
Vaughn C, Zhang L, Schiff D, Reversible posterior leukoencephalopathy syndrome in cancer., 2008; Curr Oncol Rep. 10(1) 86-91. PMID:
Pouratian N, Asthagiri A, Jagannathan J, Shaffrey ME, Schiff D, Surgery Insight: the role of surgery in the management of low-grade gliomas., 2007; Nat Clin Pract Neurol. 3(11) 628-39. PMID:
Pouratian N, Gasco J, Sherman JH, Shaffrey ME, Schiff D, Toxicity and efficacy of protracted low dose temozolomide for the treatment of low grade gliomas., 2007; J Neurooncol. 82(3) 281-8. PMID:
Traul DE, Shaffrey ME, Schiff D, Part I: spinal-cord neoplasms-intradural neoplasms., 2007; Lancet Oncol. 8(1) 35-45. PMID:
Sansur CA, Pouratian N, Dumont AS, Schiff D, Shaffrey CI, Shaffrey ME, Part II: spinal-cord neoplasms--primary tumours of the bony spine and adjacent soft tissues., 2007; Lancet Oncol. 8(2) 137-47. PMID:
Da AN, Schiff D, Adrenal insufficiency secondary to glucocorticoid withdrawal in patients with brain tumor., 2007; Surg Neurol. 67(5) 508-10. PMID:
Schiff D, Temozolomide and radiation in low-grade and anaplastic gliomas: temoradiation., 2007; Cancer Invest. 25(8) 776-84. PMID:
Schiff D, Brown PD, Giannini C, Outcome in adult low-grade glioma: the impact of prognostic factors and treatment., 2007; Neurology. 69(13) 1366-73. PMID:
Daly FN, Schiff D, Supportive management of patients with brain tumors., 2007; Expert Rev Neurother. 7(10) 1327-36. PMID:
Da AN, Heras-Herzig A, Schiff D, Bone health in patients with brain tumors., 2007; Surg Neurol. 68(5) 525-33. PMID:
Kannarkat G, Lasher EE, Schiff D, Neurologic complications of chemotherapy agents., 2007; Curr Opin Neurol. 20(6) 719-25. PMID:
Schiff D, Wen P, Central nervous system toxicity from cancer therapies., 2006; Hematol Oncol Clin North Am. 20(6) 1377-98. PMID:
Da AN, Lopes MB, Schiff D, Rare pathological variants and presentations of primary central nervous system lymphomas., 2006; Neurosurg Focus. 21(5) E7. PMID:
Schiff D, Jensen ME, Kyphoplasty in cancer: an encouraging step., ; Lancet Oncol. 12(3) 202-3. PMID:
Da AN, Schiff D, Dural and skull base metastases., ; Cancer Treat Res. 136(0) 117-41. PMID:
Sherman JH, Moldovan K, Yeoh HK, Starke RM, Pouratian N, Shaffrey ME, Schiff D, Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomas., ; J Neurosurg. 114(6) 1617-21. PMID:
Mut M, Shaffrey ME, Schiff D, Altered consciousness associated with brain neoplasms., ; Handb Clin Neurol. 90(0) 265-81. PMID: