Frederick G. Hayden

Professor Emeritus, Medicine- Infectious Diseases and International Health

Primary Location

PO Box 801342
345 Crispell Drive, MR-6 2nd floor, Room 2522
Charlottesville, VA 22908

Primary Phone Number

434.924.5059

Fax Number

434.924.0075

[email protected]

Bio & Overview

Our research activities have focused on the application of antiviral agents for the prevention and treatment of respiratory viral infections. The scope of studies ranges from in vitro assays of viral susceptibility and antiviral mechanisms of action to clinical trials involving experimentally induced and naturally occurring infections. For example, prior work established the effectiveness of intranasal interferons in preventing transmission of rhinovirus colds, the safety and pharmacology of rimantadine HCI, the transmission of drug- resistant influenza A viruses in families, the anti-rhinovirus mechanism of action and antiviral activity of soluble ICAM-1, and the antiviral activity and clinical use of influenza neuraminidase inhibitors; oseltamivir and zanamivir, and the anti-picornavirus agent, pleconaril. Areas of current investigation include application of nucleic acid hybridization to study picornavirus epidemiology, determining the phenotypic and genotypic basis of antiviral drug resistance in rhino and influenza viruses, clinical testing of the several candidate antiviral agents for influenza and rhinovirus infections, and studies of host inflammatory response modifying agents in the pathogenesis of rhinovirus infections.

Academic Information

Department: Medicine- Infectious Diseases and International Health

Academic Title: Professor

Primary Education

BA, Stanford University, 1971
MD, Stanford University, 1973

Research Interests

Antiviral agents for the prevention and treatment of respiratory viral infections

Selected Publications

Hui DS, Hayden FG, Editorial commentary: host and viral factors in emergent influenza virus infections., 2014; Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 58(8) 1104-6. PMID: 24488976

Hayden FG, Newer influenza antivirals, biotherapeutics and combinations., 2013; Influenza and other respiratory viruses. 7() 63-75. PMID: 23279899

Bresee J, Hayden FG, Epidemic influenza--responding to the expected but unpredictable., 2013; The New England journal of medicine. 368(7) 589-92. PMID: 23343038

Hay AJ, Hayden FG, Oseltamivir resistance during treatment of H7N9 infection., 2013; Lancet. 381(9885) 2230-2. PMID: 23809549

Chan JF, Chan KH, Kao RY, To KK, Zheng BJ, Li CP, Li PT, Dai J, Mok FK, Chen H, Hayden FG, Yuen KY, Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., 2013; The Journal of infection. 67(6) 606-16. PMID: 24096239

Cao B, Hayden FG, Therapy of H7N9 pneumonia: current perspectives., 2013; Expert review of anti-infective therapy. 11(11) 1123-6. PMID: 24151830

Hurt AC, Ison MG, Hayden FG, Hay AJ, Second isirv antiviral group conference: overview., 2013; Influenza and other respiratory viruses. 7() 1-7. PMID: 24215376

Hayden FG, Advances in antivirals for non-influenza respiratory virus infections., 2013; Influenza and other respiratory viruses. 7() 36-43. PMID: 24215380

Welkers MR, Dunning J, Wong CH, de Jong MD, Hayden FG, Current research on respiratory viral infections: XIIth International Symposium., 2012; Antiviral therapy. 17(1) 227-53. PMID: 22311667

Perelson AS, Rong L, Hayden FG, Combination antiviral therapy for influenza: predictions from modeling of human infections., 2012; The Journal of infectious diseases. 205(11) 1642-5. PMID: 22448006

Hughes B, Hayden F, Perikov Y, Hombach J, Tam JS, Report of the 5th meeting on influenza vaccines that induce broad spectrum and long-lasting immune responses, World Health Organization, Geneva, 16-17 November 2011., 2012; Vaccine. 30(47) 6612-22. PMID: 22981850

Hollmeyer H, Hayden F, Mounts A, Buchholz U, Review: interventions to increase influenza vaccination among healthcare workers in hospitals., 2012; Influenza and other respiratory viruses. 7(4) 604-21. PMID: 22984794

McCullers JA, Hayden FG, Fatal influenza B infections: time to reexamine influenza research priorities., 2012; The Journal of infectious diseases. 205(6) 870-2. PMID: 22291194

Hayden FG, Experimental human influenza: observations from studies of influenza antivirals., 2012; Antiviral therapy. 17(1) 133-41. PMID: 22311616

de Jong MD, Hayden FG, Spotlight on respiratory viruses 2012: introduction., 2012; Antiviral therapy. 17(1) 131-2. PMID: 22311627

Hayden FG, Turner RB, Rhinovirus genetics and virulence: looking for needles in a haystack., 2012; American journal of respiratory and critical care medicine. 186(9) 818-20. PMID: 23118081

Aoki FY, Hayden FG, The beneficial effects of neuraminidase inhibitor drug therapy on severe patient outcomes during the 2009-2010 influenza A virus subtype H1N1 pandemic., 2012; The Journal of infectious diseases. 207(4) 547-9. PMID: 23204176

Hurt AC, Chotpitayasunondh T, Cox NJ, Daniels R, Fry AM, Gubareva LV, Hayden FG, Hui DS, Hungnes O, Lackenby A, Lim W, Meijer A, Penn C, Tashiro M, Uyeki TM, Zambon M, Antiviral resistance during the 2009 influenza A H1N1 pandemic: public health, laboratory, and clinical perspectives., 2011; The Lancet infectious diseases. 12(3) 240-8. PMID: 22186145

Howard WA, Peiris M, Hayden FG, Report of the 'mechanisms of lung injury and immunomodulator interventions in influenza' workshop, 21 March 2010, Ventura, California, USA., 2011; Influenza and other respiratory viruses. 5(6) 453-4, e458-75. PMID: 21848616

Belser JA, Snider CB, Cox NJ, Hayden FG, XIth International Symposium on Respiratory Viral Infections., 2011; Influenza and other respiratory viruses. 5(6) 443-52, e455-7. PMID: 21668671