Skip to main content
Sumeet Anand Khetarpal

Sumeet Anand Khetarpal

Assistant Professor of Medicine, Medicine- Cardiovascular Medicine

Email
[email protected]
Website
https://www.cvrc.virginia.edu/Khetarpal/

Bio & Overview

My research program at the University of Virginia (UVA) investigates how the heart communicates with other organs to regulate systemic metabolism, and how these pathways can be targeted to treat cardiovascular and metabolic disease. We focus on two intertwined axes of inter-organ crosstalk: (i) lipoprotein physiology and lipid signaling that shape cardiometabolic risk, and (ii) heart-derived secreted proteins (“cardio-myokines”) that govern adaptation to exercise and drive maladaptive remodeling in disease. Methodologically, the lab integrates mouse genetics and physiology (exercise and heart-failure models), viral vector–mediated gene delivery, primary cell culture, quantitative proteomics and lipidomics, and human genetic/proteomic datasets. At UVA’s Cardiovascular Research Center, my lab will extend this genetics-to-mechanism paradigm across three synergistic thrusts: (1) discover and define heart-derived proteins that control systemic metabolism and cardiac remodeling (leveraging ECF proteomics, gain/loss-of-function, and receptor/ligand mapping); (2) dissect how lipoprotein regulators (e.g., APOC3-centered pathways) influence cardiac and skeletal-muscle bioenergetics and endothelial function in exercise vs. heart failure; and (3) translate these insights using human genetic and proteomic resources to prioritize therapeutic entry points. This integrated program offers trainees rigorous, multi-modal training at the interface of basic metabolism, cardiovascular biology, and human genetics, with a clear path from discovery to translational relevance.

Academic Information

Department
Medicine- Cardiovascular Medicine

Other Affiliations

  • Cardiovascular Research Center

Research Interests

Cardiovascular Biology

Research Disciplines

  • Cardiovascular Biology
  • Genetics
  • Metabolism

Research Opportunities

  • Experimental Pathology

PhD Programs

  • Experimental Pathology

Selected Publications

Pubmed: https://pubmed.ncbi.nlm.nih.gov/?term=Khetarpal+SA%5Bauthor+name%5D&sort=pubdate

Google Scholar: https://scholar.google.com/citations?user=J5RasHoAAAAJ&hl=en

1) Khetarpal SA, Li H, Vitale T, Rhee J, Challa S, Castro C, Pabel S, Sun Y, Liu J, Bogoslavski D, Vargas-Castillo A, Smythers AL, Blackmore KA, Grauvogel L, Mittenbühler MJ, Khandekar MJ, Curtin C, Narvaez-Paliza JM, Wang C, Houstis NE, Sprenger H-G, Jurgens SJ, Biddinger KJ, Kuznetsov A, Freeman R, Ellinor PT, Nahrendorf M, Paulo JA, Gygi SP, Dumesic PA, Asnani A, Aragam KG, Puigserver P, Roh JD, Spiegelman BM*, Rosenzweig A*. Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α. Nature Cardiovascular Research. In press. *Denotes equal co-authorship. PMID: 40993371.

2) Khetarpal SA, Li H, Lerchenmüller C, Rhee J, Rosenzweig A. Molecular Mediators of the Cardiac Benefits of Exercise. Circulation Research. 2025 Jul 7;137(2):163-183. Review. PMID: 40608861.

3) Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AV, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, Lund-Katz S, Phillips MC, Tall AR, Kathiresan S, DaSilva-Jardine P, Yates NA, Rader DJ. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nature Medicine. 2017, Sep; 23(9): 1086-1094. PMCID: 28825717.

4) Khetarpal SA*, Schjoldager KT*, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ. Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. Cell Metabolism. 2016 Aug 9;24(2):234-45. * Denotes equal co-authorship. PMCID: 27508872.

5) Zanoni P*, Khetarpal SA*, Larach DB*, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF,  Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ; CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016 Mar 11;351(6278):1166-71. * Denotes equal co-authorship. PMCID: 26965621.