Skip to main content
Joshua C. Eby

Joshua C. Eby

Associate Professor, Medicine- Infectious Diseases and International Health

Primary Location
Po Box 801340
Charlottesville, VA 22908
Primary Phone Number
Fax Number
434.924.0075

Bio & Overview

Pathogenesis of Bordetella pertussis infection. Interaction of bacterial protein toxins with host target cells. Clinical diagnostics for adult and pediatric pertussis.

Academic Information

Department
Medicine- Infectious Diseases and International Health
Academic Title
Postdoctoral Researcher

Primary Education

  • BS, Yale University, 1997
  • MD, Stanford University, 2003

Other Appointments

  • MII

Research Interests

Pathogenesis of Bordetella pertussis infection. Interaction of bacterial protein toxins with host target cells. Clinical diagnostics for adult and pediatric pertussis.

Selected Publications

2024

Hicks, A. S., & Eby, J. C. (2024). The Value of Outpatient Parenteral Antimicrobial Therapy: Better Care in 27 Minutes. CLINICAL INFECTIOUS DISEASES. doi:10.1093/cid/ciae263

Madaline, T., Classen, D. C., & Eby, J. C. (2024). Building the Future of Infectious Diseases: A Call to Action for Quality Improvement Research and Measurement. JOURNAL OF INFECTIOUS DISEASES. doi:10.1093/infdis/jiae176

Hicks, A. S., Dolan, M. A., Shah, M. D., Elwood, S. E., Platts-Mills, J. A., Madden, G. R., . . . Eby, J. C. (2024). Early Initiation of Ceftaroline-Based Combination Therapy for Methicillin-resistant Staphylococcus aureus Bacteremia.. Res Sq. doi:10.21203/rs.3.rs-4095478/v1

2023

Kovacik, C. N., Shah, M. D., Thomas, T. A., & Eby, J. C. (2023). First-Dose Antimicrobial Infusion Reactions in Patients Enrolled in Outpatient Parenteral Antimicrobial Therapy Services. OPEN FORUM INFECTIOUS DISEASES, 10(6). doi:10.1093/ofid/ofad239

O'Connor, L. F., Madden, G. R., Stone, D., Classen, D. C., & Eby, J. C. (2023). Risk Factors for Severe COVID-19 Among Health Care Workers. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 65(6), 529-532. doi:10.1097/JOM.0000000000002843

Smirnov, A., Daily, K. P., Gray, M. C., Ragland, S. A., Werner, L. M., Johnson, M. B., . . . Criss, A. K. (2023). Phagocytosis via complement receptor 3 enables microbes to evade killing by neutrophils. JOURNAL OF LEUKOCYTE BIOLOGY, 114(1), 1-20. doi:10.1093/jleuko/qiad028

2022

Eby, J. C., Richey, M. M., Sifri, C. D., & Schuch, J. Z. (2022). Influence of critically appraising exemption requests from healthcare personnel along a spectrum of influenza vaccine hesitancy. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 43(11), 1672-1678. doi:10.1017/ice.2021.513

2021

Sheridan, K. R., Lane, M. A., Kim, T. J., & Eby, J. C. (2021). Infectious Disease Providers' Knowledge of and Engagement in Quality Improvement. OPEN FORUM INFECTIOUS DISEASES, 8(11). doi:10.1093/ofid/ofab515

Boggs, Z. H., Heysell, S., Eby, J., & Arnold, C. (2021). Adenosine deaminase negative pleural tuberculosis: a case report. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06276-4

Gandhi, A. M., Shah, M. D., Donohue, L. E., Cox, H. L., & Eby, J. C. (2021). Tolerability of Cefazolin in Nafcillin-Intolerant Patients for the Treatment of Methicillin-Susceptible Staphylococcus aureus Infections. CLINICAL INFECTIOUS DISEASES, 73(9), 1650-1655. doi:10.1093/cid/ciab368

Barros, A. J., Sifri, C. D., Bell, T. D., Eby, J. C., & Enfield, K. B. (2021). Effectiveness of Elastomeric Half-Mask Respirators vs N95 Filtering Facepiece Respirators During Simulated Resuscitation A Nonrandomized Controlled Trial. JAMA NETWORK OPEN, 4(3). doi:10.1001/jamanetworkopen.2021.1564

2019

Gonyar, L. A., Gelbach, P. E., McDuffie, D. G., Koeppel, A. F., Chen, Q., Lee, G., . . . Eby, J. C. (2019). In Vivo Gene Essentiality and Metabolism in Bordetella pertussis. MSPHERE, 4(3). doi:10.1128/mSphere.00694-18

Wong, T. Y., Hall, J. M., Nowak, E. S., Boehm, D. T., Gonyar, L. A., Hewlett, E. L., . . . Damron, F. H. (2019). Analysis of the In Vivo Transcriptome of Bordetella pertussis during Infection of Mice. MSPHERE, 4(2). doi:10.1128/mSphereDirect.00154-19

2018

Eby, J. C. (2019). Exploring Standard Endpoints for Clinical Trials of Pneumonia Therapy. JOURNAL OF INFECTIOUS DISEASES, 219(10), 1515-1517. doi:10.1093/infdis/jiy708

Eby, J. C., Lane, M. A., Horberg, M., Gentry, C. N., Coffin, S. E., Ray, A. J., . . . Nahass, R. G. (2019). How Do You Measure Up: Quality Measurement for Improving Patient Care and Establishing the Value of Infectious Diseases Specialists. CLINICAL INFECTIOUS DISEASES, 68(11), 1946-1951. doi:10.1093/cid/ciy814

Shenoy, A., El-Nahal, W., Walker, M., Chopra, T., Townsend, G., Heysell, S., & Eby, J. (2018). Management of a Mycobacterium immunogenum infection of a peritoneal dialysis catheter site. INFECTION, 46(6), 875-880. doi:10.1007/s15010-018-1199-0

Gray, M. E., Cox, H. L., Donohue, L. E., Poulter, M. D., Eby, J. C., & Mathers, A. J. (2018). The effect of rapid diagnostic testing with Infectious Diseases fellow consultative intervention on the management of enterococcal bloodstream infection. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 92(4), 319-324. doi:10.1016/j.diagmicrobio.2018.07.004

2017

Eby, J. C., Mathers, A. J., Cox, H. L., Richey, M. M., Platts-Mills, J. A., & Novicoff, W. M. (2018). A Request for Standardization of Publishing of Blood Culture Processing Interventions Reply. CLINICAL INFECTIOUS DISEASES, 66(9), 1485. doi:10.1093/cid/cix1017

Eby, J. C., Richey, M. M., Platts-Mills, J. A., Mathers, A. J., Novicoff, W. M., & Cox, H. L. (2018). A Healthcare Improvement Intervention Combining Nucleic Acid Microarray Testing With Direct Physician Response for Management of Staphylococcus aureus Bacteremia. CLINICAL INFECTIOUS DISEASES, 66(1), 64-71. doi:10.1093/cid/cix727

Shen, K. R., Bribriesco, A., Crabtree, T., Denlinger, C., Eby, J., Eiken, P., . . . Kozower, B. (2017). The American Association for Thoracic Surgery consensus guidelines for the management of empyema. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 153(6), E129-E146. doi:10.1016/j.jtcvs.2017.01.030

Eby, J. C., Gray, M. C., Warfel, J. M., Merkel, T. J., & Hewlett, E. L. (2017). Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis. CLINICAL AND VACCINE IMMUNOLOGY, 24(1). doi:10.1128/CVI.00370-16

2016

Gray, M., Hall, H. C., Poulter, M., Eby, J., & Mathers, A. (2016). Impact of Infectious Disease Fellow Consultative Intervention Combined With a Rapid Gram-Positive Blood Culture Microarray on Outcomes for Patients With Enterococcal Bloodstream Infection. Open Forum Infectious Diseases, 3(suppl_1). doi:10.1093/ofid/ofw172.718

Kolbe, L., Cox, H., Poulter, M., Eby, J., & Mathers, A. (2016). Vancomycin Exposure in Patients With Coagulase-Negative Staphylococcus Identified From Blood Cultures Before and After Introduction of a Rapid Microarray Assay. Open Forum Infectious Diseases, 3(suppl_1). doi:10.1093/ofid/ofw172.35

Hoffman, C., Eby, J., Gray, M., Damron, F. H., Melvin, J., Cotter, P., & Hewlett, E. (2017). Bordetella adenylate cyclase toxin interacts with filamentous haemagglutinin to inhibit biofilm formation in vitro. MOLECULAR MICROBIOLOGY, 103(2), 214-228. doi:10.1111/mmi.13551

Eby, J. C., Turner, L., Bryan, N., Kang, J., Neville, C., & Temple, L. (2016). Complete Genome Sequence of Bordetella pertussis Strain VA-190 Isolated from a Vaccinated 10-Year-Old Patient with Whooping Cough. GENOME ANNOUNCEMENTS, 4(5). doi:10.1128/genomeA.00972-16

2015

Eby, J. C., Hoffman, C. L., Gonyar, L. A., & Hewlett, E. L. (2015). Review of the neutrophil response to Bordetella pertussis infection. PATHOGENS AND DISEASE, 73(9). doi:10.1093/femspd/ftv081

2014

Eby, J. C., Gray, M. C., & Hewlett, E. L. (2014). Cyclic AMP-Mediated Suppression of Neutrophil Extracellular Trap Formation and Apoptosis by the Bordetella pertussis Adenylate Cyclase Toxin. INFECTION AND IMMUNITY, 82(12), 5256-5269. doi:10.1128/IAI.02487-14

2013

Eby, J. C., Gray, M. C., Warfel, J. M., Paddock, C. D., Jones, T. F., Day, S. R., . . . Hewlett, E. L. (2013). Quantification of the Adenylate Cyclase Toxin of Bordetella pertussis In Vitro and during Respiratory Infection. INFECTION AND IMMUNITY, 81(5), 1390-1398. doi:10.1128/IAI.00110-13

2012

Donato, G. M., Goldsmith, C. S., Paddock, C. D., Eby, J. C., Gray, M. C., & Hewlett, E. L. (2012). Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles. FEBS LETTERS, 586(4), 459-465. doi:10.1016/j.febslet.2012.01.032

2011

Eby, J. C., Gray, M. C., Mangan, A. R., Donato, G. M., & Hewlett, E. L. (2012). Role of CD11b/CD18 in the Process of Intoxication by the Adenylate Cyclase Toxin of Bordetella pertussis. INFECTION AND IMMUNITY, 80(2), 850-859. doi:10.1128/IAI.05979-11

2010

Eby, J. C., Ciesla, W. P., Hamman, W., Donato, G. M., Pickles, R. J., Hewlett, E. L., & Lencer, W. I. (2010). Selective Translocation of the Bordetella pertussis Adenylate Cyclase Toxin across the Basolateral Membranes of Polarized Epithelial Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(14), 10662-10670. doi:10.1074/jbc.M109.089219