Herr, John C.

John C. Herr

John C. Herr

Primary Appointment

Professor, Cell Biology


  • PhD, Anatomy and Cell Biology, University of Iowa
  • Postdoc-Res, Developmental Biology, University of Washington School of Medicine, Seattle, WA

Contact Information

Jordan Hall, 2-27
Charlottesville, VA 22908
Telephone: 434-924-2007
Email: jch7k@virginia.edu
Website: http://www.healthsystem.virginia.edu/internet/crcrh/people/jch7k.cfm

Research Interests

Spermatogenesis and oogenesis; fertilization; cancer-testis and cancer-oocyte neoantigens.

Research Description

Dr. Herr is a reproductive and developmental cell biologist with a primary interest in genes and proteins that are expressed specifically in the sperm and in the egg [spermatogenesis and oogenesis]. His laboratory studies sperm proteins involved in motility, capacitation, the acrosome reaction, and fertilization, as well as egg proteins involved in fertilization and early embryogenesis, particularly egg membrane metalloproteases involved in sperm-egg recognition and RNA binding proteins involved in pre-patterning. His laboratory studies not only the fundamental process of gamete development and fertilization but also applies the knowledge gained to practical applications in human biology through intellectual property creation and technology transfer. One interest is to identify tumors that revert to the gametogenic pathway and to define biomarkers and drug targets useful in cancer diagnosis and immunotherapy. Another aim is to identify drug targets for new non-steroidal approaches for male and female contraception. Dr. Herr has been awarded more than 25 patents and is a Fellow of the National Academy of Inventors. Link to Dr. Herr's Ted Talk to get the flavor of his research on cancer-oocyte neoantigens: https://www.youtube.com/watch?v=NfhNlqL6y1E&list=PLsRNoUx8w3rPpWtR0UJ8Y4_WqLnGjM7uR&index=4

Selected Publications