Joel M Linden

Dolina, J. S., Lee, J., Moore, E. L., Hope, J. L., Gracias, D. T., Matsutani, T., . . . Schoenberger, S. P. (2022). Developmentally distinct CD4⁺ T_reg lineages shape the CD8⁺ T cell response to acute Listeria infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(10). doi:10.1073/pnas.2113329119

Wang, L., Londono, L. M., Cowell, J., Saatci, O., Aras, M., Ersan, P. G., . . . Cekic, C. (2021). Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors.. Cancer research, 81(12), 3319-3332. doi:10.1158/0008-5472.can-21-0340

Dhanwani, R., Takahashi, M., Mathews, I. T., Lenzi, C., Romanov, A., Watrous, J. D., . . . Sharma, S. (2020). Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response. SCIENCE ADVANCES, 6(30). doi:10.1126/sciadv.aba3688

Chen, S., Akdemir, I., Fan, J., Linden, J., Zhang, B., & Cekic, C. (2020). The Expression of Adenosine A2B Receptor on Antigen-Presenting Cells Suppresses CD8⁺ T-cell Responses and Promotes Tumor Growth. CANCER IMMUNOLOGY RESEARCH, 8(8), 1064-1074. doi:10.1158/2326-6066.CIR-19-0833

Lindner, J. R., Belcik, T., Widlansky, M., Harmann, L. M., Karafin, M. S., Wandersee, N. J., . . . Field, J. J. (2019). Contrast-enhanced ultrasound detects changes in microvascular blood flow in adults with sickle cell disease. PLOS ONE, 14(7). doi:10.1371/journal.pone.0218783

Yu, J. C., Lin, G., Field, J. J., & Linden, J. (2018). Induction of antiinflammatory purinergic signaling in activated human iNKT cells. JCI INSIGHT, 3(17). doi:10.1172/jci.insight.91954

Franco, A., Kumar, J., Lin, G., Behnamfar, N., Hsieh, L. -E., Shimizu, C., . . . Linden, J. (2018). Pediatric tolerogenic DCs expressing CD4 and immunoglobulin-like transcript receptor (ILT)-4 secrete IL-10 in response to Fc and adenosine. EUROPEAN JOURNAL OF IMMUNOLOGY, 48(3), 482-491. doi:10.1002/eji.201747139

Young, A., Ngiow, S. F., Gao, Y., Patch, A. -M., Barkauskas, D. S., Messaoudene, M., . . . Smyth, M. J. (2018). A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment. CANCER RESEARCH, 78(4), 1003-1016. doi:10.1158/0008-5472.CAN-17-2826

Field, J. J., Majerus, E., Gordeuk, V. R., Gowhari, M., Hoppe, C., Heeney, M. M., . . . Nathan, D. G. (2017). Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease. BLOOD ADVANCES, 1(20), 1645-1649. doi:10.1182/bloodadvances.2017009613

Davidson, B. P., Belcik, J. T., Landry, G., Linden, J., & Lindner, J. R. (2017). Exercise versus vasodilator stress limb perfusion imaging for the assessment of peripheral artery disease. ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 34(8), 1187-1194. doi:10.1111/echo.13601

Acuff, N. V., & Linden, J. (2017). Using Visualization of t-Distributed Stochastic Neighbor Embedding To Identify Immune Cell Subsets in Mouse Tumors. JOURNAL OF IMMUNOLOGY, 198(11), 4539-4546. doi:10.4049/jimmunol.1602077

Belcik, J. T., Davidson, B. P., Xie, A., Wu, M. D., Yadava, M., Qi, Y., . . . Lindner, J. R. (2017). Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling. CIRCULATION, 135(13), 1240-1252. doi:10.1161/CIRCULATIONAHA.116.024826

Pei, H., & Linden, J. (2016). Adenosine influences myeloid cells to inhibit aeroallergen sensitization. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 310(10), L985-L992. doi:10.1152/ajplung.00330.2015

Cekic, C., & Linden, J. (2016). Purinergic regulation of the immune system. NATURE REVIEWS IMMUNOLOGY, 16(3), 177-192. doi:10.1038/nri.2016.4

Linden, J. (2016). Optimizing radiation for cancer immunotherapy. TRANSLATIONAL CANCER RESEARCH, 5(2), 191-193. doi:10.21037/tcr.2016.01.10

Nayak, S., Khan, M. A. H., Wan, T. C., Pei, H., Linden, J., Dwinell, M. R., . . . Auchampach, J. A. (2015). Characterization of Dahl salt-sensitive rats with genetic disruption of the A_2B adenosine receptor gene: implications for A_2B adenosine receptor signaling during hypertension. PURINERGIC SIGNALLING, 11(4), 519-531. doi:10.1007/s11302-015-9470-7

Wu, M. D., Belcik, J. T., Qi, Y., Zhao, Y., Benner, C., Pei, H., . . . Lindner, J. R. (2015). Abnormal Regulation of Microvascular Tone in a Murine Model of Sickle Cell Disease Assessed by Contrast Ultrasound. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 28(9), 1122-1128. doi:10.1016/j.echo.2015.05.012

Belcik, J. T., Mott, B. H., Xie, A., Zhao, Y., Kim, S., Lindner, N. J., . . . Lindner, J. R. (2015). Augmentation of Limb Perfusion and Reversal of Tissue Ischemia Produced by Ultrasound-Mediated Microbubble Cavitation. Circulation-Cardiovascular Imaging, 8(4). doi:10.1161/CIRCIMAGING.114.002979

Beech, J., Saleh, L., Frentzel, J., Figler, H., Corrêa, I. R., Baker, B., . . . Kelly, K. A. (2015). Multivalent site-specific phage modification enhances the binding affinity of receptor ligands.. Bioconjugate chemistry, 26(3), 529-536. doi:10.1021/acs.bioconjchem.5b00011

Tian, Y., Marshall, M., French, B. A., Linden, J., & Yang, Z. (2015). The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A₃ and A_2A receptors. BASIC RESEARCH IN CARDIOLOGY, 110(2). doi:10.1007/s00395-015-0473-x

Beech, J., Saleh, L., Frentzel, J., Figler, H., Correa, I. R. J., Baker, B., . . . Kelly, K. A. (2015). Multivalent Site-Specific Phage Modification Enhances the Binding Affinity of Receptor Ligands. BIOCONJUGATE CHEMISTRY, 26(3), 529-536. doi:10.1021/acs.bioconjchem.5b00011

Field, J. J., Nathan, D. G., & Linden, J. (2014). The Role of Adenosine Signaling in Sickle Cell Therapeutics. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 28(2), 287-+. doi:10.1016/j.hoc.2013.11.003

Tian, Y., Linden, J., French, B. A., & Yang, Z. (2014). Atorvastatin at Reperfusion Reduces Myocardial Infarct Size in Mice by Activating eNOS in Bone Marrow-Derived Cells. PLOS ONE, 9(12). doi:10.1371/journal.pone.0114375

Kennedy, D. P., McRobb, F. M., Leonhardt, S. A., Purdy, M., Figler, H., Marshall, M. A., . . . Yeager, M. (2014). The Second Extracellular Loop of the Adenosine A₁ Receptor Mediates Activity of Allosteric Enhancers. MOLECULAR PHARMACOLOGY, 85(2), 301-309. doi:10.1124/mol.113.088682

Linden, J. M., Koepple, M., Elder, D., & Gibson, A. G. (2014). Fracture mechanics of crack propagation in composite repairs of steel pressure piping. JOURNAL OF REINFORCED PLASTICS AND COMPOSITES, 33(6), 526-532. doi:10.1177/0731684413500366

Linden, J. (2013). Adenosine Promotes Tumor Metastasis. SCIENCE SIGNALING, 6(277). doi:10.1126/scisignal.2004290

Field, J. J., Lin, G., Okam, M. M., Majerus, E., Keefer, J., Onyekwere, O., . . . Nathan, D. G. (2013). Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A_2A receptor agonist regadenoson. BLOOD, 121(17), 3329-3334. doi:10.1182/blood-2012-11-465963

Lin, G., Field, J. J., Yu, J. C., Ken, R., Neuberg, D., Nathan, D. G., & Linden, J. (2013). NF-κB Is Activated in CD4⁺ iNKT Cells by Sickle Cell Disease and Mediates Rapid Induction of Adenosine A_2A Receptors. PLOS ONE, 8(10). doi:10.1371/journal.pone.0074664

Li, Y., Figler, R. A., Kolling, G., Bracken, T. C., Rieger, J., Stevenson, R. W., . . . Warren, C. A. (2012). Adenosine A_2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment. BMC INFECTIOUS DISEASES, 12. doi:10.1186/1471-2334-12-342

Chhabra, P., Linden, J., Lobo, P., Okusa, M. D., & Brayman, K. L. (2012). The Immunosuppressive Role of Adenosine A_2A Receptors in Ischemia Reperfusion Injury and Islet Transplantation. CURRENT DIABETES REVIEWS, 8(6), 419-433. doi:10.2174/157339912803529878

Li, L., Huang, L., Ye, H., Song, S. P., Bajwa, A., Lee, S. J., . . . Okusa, M. D. (2012). Dendritic cells tolerized with adenosine A_2AR agonist attenuate acute kidney injury. JOURNAL OF CLINICAL INVESTIGATION, 122(11), 3931-3942. doi:10.1172/JCI63170

Warren, C. A., Li, Y., Calabrese, G. M., Freire, R. S., Zaja-Milatovic, S., van Opstal, E., . . . Guerrant, R. L. (2012). Contribution of Adenosine A_2B Receptors in Clostridium difficile Intoxication and Infection. INFECTION AND IMMUNITY, 80(12), 4463-4473. doi:10.1128/IAI.00782-12

Barletta, K. E., Cagnina, R. E., Burdick, M. D., Linden, J., & Mehrad, B. (2012). Adenosine A_2B Receptor Deficiency Promotes Host Defenses against Gram-Negative Bacterial Pneumonia. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 186(10), 1044-1050. doi:10.1164/rccm.201204-0622OC

Linden, J. (2012). TRANSLATIONAL MEDICINE Longer life for artificial joints. NATURE, 487(7406), 179-180. doi:10.1038/487179a

Harris, D. A., Zhao, Y., LaPar, D. J., Emaminia, A., Steidle, J. F., Stoler, M., . . . Lau, C. L. (2013). Inhibiting CXCL12 blocks fibrocyte migration and differentiation and attenuates bronchiolitis obliterans in a murine heterotopic tracheal transplant model. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 145(3), 854-861. doi:10.1016/j.jtcvs.2012.03.079

Linden, J. (2012). Statins Counter the Effects of Hyperlipidemia on iNKT Cells Editorial to: "Statin-Induced Immunomodulation Alters Peripheral Invariant Natural Killer T-Cell Prevalence in Hyperlipidemic Patients" by E. Nakou et al.. CARDIOVASCULAR DRUGS AND THERAPY, 26(4), 277-279. doi:10.1007/s10557-012-6391-3

Linden, J. (2012). Role of Adenosine in Response to Vascular Inflammation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(4), 843-844. doi:10.1161/ATVBAHA.112.247874

Warren, C. A., Calabrese, G. M., Li, Y., Pawlowski, S. W., Figler, R. A., Rieger, J., . . . Guerrant, R. L. (2012). Effects of adenosine A_2A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice. BMC INFECTIOUS DISEASES, 12. doi:10.1186/1471-2334-12-13

Field, J. J., Burdick, M. D., DeBaun, M. R., Strieter, B. A., Liu, L., Mehrad, B., . . . Strieter, R. M. (2012). The Role of Fibrocytes in Sickle Cell Lung Disease. PLOS ONE, 7(3). doi:10.1371/journal.pone.0033702

Cekic, C., Sag, D., Li, Y., Theodorescu, D., Strieter, R. M., & Linden, J. (2012). Adenosine A_2B Receptor Blockade Slows Growth of Bladder and Breast Tumors. JOURNAL OF IMMUNOLOGY, 188(1), 198-205. doi:10.4049/jimmunol.1101845

Emaminia, A., LaPar, D. J., Zhao, Y., Steidle, J. F., Harris, D. A., Laubach, V. E., . . . Lau, C. L. (2011). Adenosine A_2A Agonist Improves Lung Function During Ex Vivo Lung Perfusion. ANNALS OF THORACIC SURGERY, 92(5), 1840-1846. doi:10.1016/j.athoracsur.2011.06.062

Barletta, K. E., Cagnina, R. E., Wallace, K. L., Ramos, S. I., Mehrad, B., & Linden, J. (2012). Leukocyte compartments in the mouse lung: Distinguishing between marginated, interstitial, and alveolar cells in response to injury. JOURNAL OF IMMUNOLOGICAL METHODS, 375(1-2), 100-110. doi:10.1016/j.jim.2011.09.013

Wilson, J. M., Kurtz, C. C., Black, S. G., Ross, W. G., Alam, M. S., Linden, J., & Ernst, P. B. (2011). The A_2B Adenosine Receptor Promotes Th17 Differentiation via Stimulation of Dendritic Cell IL-6. JOURNAL OF IMMUNOLOGY, 186(12), 6746-6752. doi:10.4049/jimmunol.1100117

Field, J. J., Nathan, D. G., & Linden, J. (2011). Targeting iNKT cells for the treatment of sickle cell disease. CLINICAL IMMUNOLOGY, 140(2), 177-183. doi:10.1016/j.clim.2011.03.002

Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Linden, J., & Mueller, C. E. (2011). International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors-An Update. PHARMACOLOGICAL REVIEWS, 63(1), 1-34. doi:10.1124/pr.110.003285

Figler, R. A., Wang, G., Srinivasan, S., Jung, D. Y., Zhang, Z., Pankow, J. S., . . . Linden, J. (2011). Links Between Insulin Resistance, Adenosine A_2B Receptors, and Inflammatory Markers in Mice and Humans. DIABETES, 60(2), 669-679. doi:10.2337/db10-1070

Zhao, Y., LaPar, D. J., Steidle, J., Emaminia, A., Kron, I. L., Ailawadi, G., . . . Lau, C. L. (2010). Adenosine signaling via the adenosine 2B receptor is involved in bronchiolitis obliterans development. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 29(12), 1405-1414. doi:10.1016/j.healun.2010.07.005

Polanowska-Grabowska, R., Wallace, K., Field, J. J., Chen, L., Marshall, M. A., Figler, R., . . . Linden, J. (2010). P-Selectin-Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(12), 2392-U123. doi:10.1161/ATVBAHA.110.211615

Yang, M., Chordia, M. D., Li, F., Huang, T., Linden, J., & Macdonald, T. L. (2010). Neutrophil- and Myeloperoxidase-Mediated Metabolism of Reduced Nimesulide: Evidence for Bioactivation. CHEMICAL RESEARCH IN TOXICOLOGY, 23(11), 1691-1700. doi:10.1021/tx1001496

Wallace, K. L., & Linden, J. (2010). Adenosine A_2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease. BLOOD, 116(23), 5010-5020. doi:10.1182/blood-2010-06-290643

Schwindinger, W. F., Mihalcik, L. J. M., Giger, K. E., Betz, K. S., Stauffer, A. M., Linden, J., . . . Robishaw, J. D. (2010). Adenosine A_2A Receptor Signaling and G_olf Assembly Show a Specific Requirement for the γ₇ Subtype in the Striatum. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(39), 29787-29796. doi:10.1074/jbc.M110.142620

Gazoni, L. M., Walters, D. M., Unger, E. B., Linden, J., Kron, I. L., & Laubach, V. E. (2010). Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 140(2), 440-446. doi:10.1016/j.jtcvs.2010.03.002

Wang, H., Zhang, W., Tang, R., Zhu, C., Bucher, C., Blazar, B. R., . . . Huo, Y. (2010). Adenosine Receptor A_2A Deficiency in Leukocytes Increases Arterial Neointima Formation in Apolipoprotein E-Deficient Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(5), 915-U78. doi:10.1161/ATVBAHA.109.202572

Chhabra, P., Wang, K., Zeng, Q., Jecmenica, M., Langman, L., Linden, J., . . . Brayman, K. L. (2010). Adenosine A_2A Agonist Administration Improves Islet Transplant Outcome: Evidence for the Role of Innate Immunity in Islet Graft Rejection. CELL TRANSPLANTATION, 19(5), 597-612. doi:10.3727/096368910X491806